Transferable Vancomycin Resistance in a Community-Associated MRSA Lineage

Rossi, Flávia; Diaz, Lorena; Wollam, Aye; Panesso, Diana; Zhou, Yanjiao; Rincón, Sandra; Narechania, Apurva; Xing, Galen; Gioia, Thais Sabato Romano Di; Doi, André Mario; Tran, Truc T.; Reyes, Jinnethe; Munita, José M.; Carvajal, Lina P; Hernandez-Roldan, Alejandra; Brandão, Denise; Heijden, Inneke M. van der; Murray, Barbara E.; Planet, Paul J.; Weinstock, George M.; Arias, César A.

doi:10.1056/nejmoa1303359

Cited by 147 publications

(110 citation statements)

References 25 publications

(43 reference statements)

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“…The emergence of multidrug-resistant MRSA isolates acquiring glycopeptide resistance during vancomycin therapy documents the urgent need for controlling the use of antibiotics (42). Recent research efforts have been directed at developing antiinfective therapies against S. aureus, focusing on small molecules that interfere with virulence gene regulation (43).…”

Section: Discussionmentioning

confidence: 99%

Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase

Zhang

Liu

Zhu

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

133

145

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Methicillin-resistant Staphylococcus aureus (MRSA) is the most frequent cause of hospital-acquired infection, which manifests as surgical site infections, bacteremia, and sepsis. Due to drug-resistance, prophylaxis of MRSA infection with antibiotics frequently fails or incites nosocomial diseases such as Clostridium difficile infection. Sortase A is a transpeptidase that anchors surface proteins in the envelope of S. aureus, and sortase mutants are unable to cause bacteremia or sepsis in mice. Here we used virtual screening and optimization of inhibitor structure to identify 3-(4-pyridinyl)-6-(2-sodiumsulfonatephenyl) [1,2,4]

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Section: Discussionmentioning

confidence: 99%

Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase

Zhang

Liu

Zhu

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

133

145

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“…In Brazil, intermediate resistance to vancomycin in patients has been described, but few studies have reported colonization of health professionals by these strains 32 . The fi rst case of transferable vancomycin resistance in a communityassociated MRSA strain was reported in a Brazilian hospital, indicating that the presence of MRSA containing the vanA gene could be a future public problem 33 . Some studies that use ribotyping-PCR to assess genetic similarity also present ample polymorphisms, as in our study, considering the number of ribotypes observed, thus indicating dispersion in the hospital sectors 34,35 , but these studies do not make comparisons of dispersion between classes of patients and professionals.…”

Section: Discussionmentioning

confidence: 99%

The occurrence and dissemination of methicillin and vancomycin-resistant Staphylococcus in samples from patients and health professionals of a university hospital in Recife, State of Pernambuco, Brazil

Rabelo

Neto

Loibman

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) strains have been responsible for many nosocomial outbreaks. Within hospitals, colonized employees often act as reservoirs for the spread of this organism. This study collected clinical samples of 91 patients admitted to the intensive care unit (ICU), hemodialysis/nephrology service and surgical clinic, and biological samples from the nasal cavities of 120 professionals working in those environments, of a University Hospital in Recife, in the State of Pernambuco, Brazil. The main objective of this study was to determine the occurrence and dissemination of methicillin-and vancomycin-resistant Staphylococcus spp. Methods: The isolates obtained were tested for susceptibility to oxacillin and vancomycin and detection of the mecA gene. In addition, the isolates were evaluated for the presence of clones by ribotyping-polymerase chain reaction (PCR). Results: MRSA occurrence, as detected by the presence of the mecA gene, was more prevalent among nursing technicians; 48.1% (13/27) and 40.7% (11/27) of the isolates were from health professionals of the surgical clinic. In patients, the most frequent occurrence of mecA-positive isolates was among the samples from catheter tips (33.3%; 3/9), obtained mostly from the hemodialysis/nephrology service. Eight vancomycin-resistant strains were found among the MRSA isolates through vancomycin screening. Based on the amplifi cation patterns, 17 ribotypes were identifi ed, with some distributed between patients and professionals. Conclusions: Despite the great diversity of clones, which makes it diffi cult to trace the source of the infection, knowledge of the molecular and phenotypic profi les of Staphylococcus samples can contribute towards guiding therapeutic approaches in the treatment and control of nosocomial infections.

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“…Among these, vancomycin was considered as the drug of choice for treatment of MRSA infections until recently (2,4). In the past decade, vancomycin-resistant strains of S. aureus have been reported from different parts of the world (5,6). This fact has raised concerns about the efficacy of vancomycin for treatment of infections caused by S. aureus in near future (7,8).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Susceptibility Pattern of Staphylococcus aureus Isolates Against Newly Marketed Antibiotics: A Report From Imam Reza Hospital of Mashhad, Iran

Arianpoor¹,

Estaji²,

Naderinasab³

et al. 2015

Razavi Int J Med

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Background: Infections due to Staphylococcus aureus have long been considered as a big challenge to clinicians. The innate ability of this microorganism to develop resistance to different antibiotics, has led to the appearance of MRSA (methicillin-resistant Staphylococcus aureus) and lately VRSA (vancomycin-resistant Staphylococcus aureus) strains, which are considered as major problems for both patients and clinicians. Objectives: In this study, we tried to evaluate susceptibility pattern of S. aureus isolates against some prevalent antibiotics as well as some infrequent ones. Results: Out of 238 samples, 5.88% were resistant to quinupristin-dalfopristin; 5.46% to linezolid; 60.92% to Co-trimoxazole; 31.93% to doxycycline; 18.90% to tigecycline; 5.04% to vancomycin; 9.24% to mupirocin; 43% to oxacillin and 46.21% of our isolates were resistant to cefoxitin. Conclusions: Coming across isolates with reduced susceptibility to quinupristin-dalfopristin and resistant to linezolid in this study are worrisome although these antibiotics are not used in our hospital. This might be a new challenge in the treatment of MRSA.

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Transferable Vancomycin Resistance in a Community-Associated MRSA Lineage

Cited by 147 publications

References 25 publications

Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase

Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase

The occurrence and dissemination of methicillin and vancomycin-resistant Staphylococcus in samples from patients and health professionals of a university hospital in Recife, State of Pernambuco, Brazil

Antimicrobial Susceptibility Pattern of Staphylococcus aureus Isolates Against Newly Marketed Antibiotics: A Report From Imam Reza Hospital of Mashhad, Iran

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