Transfer of antibiotics and their metabolites in human milk: Implications for infant health and microbiota

Thomas, Sydney P.; Denizer, Erce; Zuffa, Simone; Best, Brookie M.; Bode, Lars; Chambers, Christina D.; Dorrestein, Pieter C.; Liu, George Y.; Momper, Jeremiah D.; Nizet, Victor; Tsunoda, Shirley M.; Tremoulet, Adriana H.

doi:10.1002/phar.2732

Cited by 6 publications

(3 citation statements)

References 94 publications

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“…The abundance of these facultative bacterial taxa decreases rapidly because of the consumption of oxygen and intestinal secretory immunoglobulin A, along with the expansion of anaerobic bacteria Bi dobacterium and Clostridium during the rst months of life 21 . However, the use of antibiotics, which is one the most disruption factor for neonatal gut microbiota development (40), strongly interfere the normal gut microbiota development at every neonatal period. Our research provides more detailed insights into the in uence of antibiotic usage on neonates of varying age groups, indicating that the use of antibiotics in neonates at any age can have a substantial impact on their gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Effect of β-Lactam Antibiotics on the Gut Microbiota of Term Neonates

Gu,

Tao,

Fan

et al. 2024

Preprint

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β-Lactam antibiotics are a class of antibiotics that are commonly used to treat bacterial infections. However, the effects of β-lactam antibiotics on term neonatal intestinal flora have not been fully elucidated. Hospitalized full-term newborns receiving β-lactam antibiotics formed the antibiotic group, while those without antibiotic treatment comprised the non-antibiotic group. A healthy group included healthy full-term newborns. Stool samples were collected for 16S rDNA sequencing to analyze gut microbiota variations. Further investigation was carried out within the β-lactam antibiotic group, exploring the effects of antibiotic use on the newborns’ gut microbiota in relation to the duration and type of antibiotic administration, delivery method, and feeding practices. The antibiotic group exhibited significant difference of microbial beta diversity compared to the other groups. Genera like Klebsiella, Enterococcus,Streptococcus, Alistipes, and Aeromonas were enriched, while Escherichia-Shigella, Clostridium sensu stricto 1, Bifidobacterium, and Parabacteroideswere reduced. Klebsiella negatively correlated with Escherichia-Shigella, positively with Enterobacter, and Escherichia-Shigella negatively correlated with Enterococcus and Streptococcus. Regardless of neonatal age, β-lactam antibiotics induced elevated Klebsiella andEnterococcus. Impact on gut microbiota varied with antibiotic duration and type (cefotaxime or ampicillin/sulbactam). Compared to vaginal delivery, cesarean delivery after β-lactam treatment heightened the abundance of Klebsiella, Enterobacteriaceae_Unclassified, Lactobacillales_Unclassified, and Pectobacterium. Feeding patterns minimally influenced β-lactam-induced alterations. In conclusion, β-lactam antibiotic treatment for neonatal pneumonia and sepsis markedly disrupted intestinal microbiota, favoring Klebsiella, Enterococcus, Streptococcus, Alistipes, and Aeromonas. β-lactam impact varied by duration, type, and delivery method, emphasizing heightened disruptions post-cesarean delivery.

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Section: Discussionmentioning

confidence: 99%

Effect of β-Lactam Antibiotics on the Gut Microbiota of Term Neonates

Gu,

Tao,

Fan

et al. 2024

Preprint

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“…Antibiotics will likely always end up in the milk (from roughly 0.05% to 10.6%), depending on the antibiotic, its hydrophilicity and concentration, and different factors such as absorption, distribution, metabolism, and elution [35]. Even low doses of antibiotics in the milk can harm the infant by changing the microbiome, increasing antibiotic-resistant genes and the risk of allergies, and contributing to morbidities such as disturbances in brain development, immunity, and behavior, and obesity [35,36].…”

Section: Discussionmentioning

confidence: 99%

Medical-Grade Honey Enhances the Healing of Caesarean Section Wounds and Is Similarly Effective to Antibiotics Combined with Povidone-Iodine in the Prevention of Infections—A Prospective Cohort Study

et al. 2023

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Caesarean sections (CS) are becoming increasingly popular. The antibiotic resistance crisis and relentless risk of infections, especially in developing countries, demand alternative treatment options. Medical-grade honey (MGH) exerts antimicrobial and healing properties. This study aims to evaluate the effect of MGH treatment on CS wound healing and postoperative complications when compared to conventional treatment (antibiotics in combination with povidone-iodine). In this prospective cohort study, 766 CS patients were included and evenly divided into two groups. The treatment group (n = 383) received an MGH-based formulation (L-Mesitran Soft) and the control group (n = 383) received antibiotics (Amoxicillin) combined with povidone-iodine. The wound healing time and complication rate were determined for both groups, and subsequently, predisposing factors for complications among the baseline characteristics and non-patient-related parameters were determined. The baseline characteristics were similar for both study groups, supporting a homogenous distribution. Postoperative complications were experienced by 19.3% of the patients in the control group and 18.8% in the treatment (MGH) group. The treatment group experienced significantly more superficial pus discharge than the control group, while the latter experienced significantly more deeper pus discharge. BMI, age, duration of hospitalization, anesthesia, and duration of CS could affect the complication risk. MGH significantly enhanced wound healing until day 42. On average, the healing time with MGH was 19.12 ± 7.760 days versus 24.54 ± 8.168 days in the control group. MGH is a potent alternative treatment to antibiotics and povidone-iodine because while the complication risk is similar, MGH has additional benefits. MGH promotes wound healing and does not bear the risk of resistance.

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“…They work by targeting bacterial cell components and altering necessary processes like DNA replication, cell wall synthesis, etc. [8][9][10]. However, they do have certain drawbacks that make them insufficient and problematic in various ways:…”

Section: Introductionmentioning

confidence: 99%

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

Kaur

Kaur²,

Alyami

et al. 2023

Antibiotics

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The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, among others, for the present review. Along with these, marketed products, patents, and Clinicaltrials.gov were also referred to for our review. Different microbes such as bacteria, fungi, etc., and their diverse species and strains have been reviewed and found to be sensitive to metal-carrying formulations. The products are observed to restrict growth, multiplication, and biofilm formation effectively and adequately. Silver has an apt use in this area of treatment and recovery, and other metals like copper, gold, iron, and gallium have also been observed to generate antimicrobial activity. The present review identified membrane disruption, oxidative stress, and interaction with proteins and enzymes to be the primary microbicidal processes. Elaborating the action, nanoparticles and nanosystems are shown to work in our favor in well excelled and rational ways.

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Transfer of antibiotics and their metabolites in human milk: Implications for infant health and microbiota

Cited by 6 publications

References 94 publications

Effect of β-Lactam Antibiotics on the Gut Microbiota of Term Neonates

Effect of β-Lactam Antibiotics on the Gut Microbiota of Term Neonates

Medical-Grade Honey Enhances the Healing of Caesarean Section Wounds and Is Similarly Effective to Antibiotics Combined with Povidone-Iodine in the Prevention of Infections—A Prospective Cohort Study

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

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