Transepithelial elimination in chromomycosis

Chromoblastomycosis Caused by Fonsecaea monophora : Using SEM and TEM to Decipher the “Blackish‐Red Dot Sign” Observed in Dermoscopy

“…The dermoscopic "blackish-red dot sign" was correlated with numerous yeast cells, as confirmed by SEM/TEM, suggesting it may serve as a diagnostic clue. Supported by TEM-observed pathogens migration from the basal layer to stratum corneum, this sign likely corresponds to "transepithelial elimination"-a host antifungal defense mechanism [1][2][3][4][5]. The resolution of blackish-red dots paralleled clinical improvement in this case, which may indicate a potential association with treatment response.…”

“…Timely diagnosis and effective treatment are critical. The "blackish-red dot sign" is a characteristic dermoscopic finding in chronic subcutaneous fungal infections [1][2][3][4][5]. We report a CBM case presenting this sign, observed via scanning and transmission electron microscopes (SEM/TEM) to evaluate its diagnostic and therapeutic monitoring potential as a dermoscopic marker.…”

Lobomycosis: an emerging disease in humans and delphinidae

“… 4,5,68 There is also an accentuated fibrosis and an enormous number of organisms eliciting hyperkeratosis and acanthosis in the epidermis 68 . Fungal forms can be seen amongst the different stratums of the epidermis suggesting transepidermic elimination 10 as has been extensively described in chromoblastomycosis 69 . Asteroid bodies which are star shaped eosinophilic intracytoplasmic structures of an apparent lipid nature are often seen (Fig.…”

Transepithelial Elimination of Benign and Malignant Tumors

“…The TE phenomenon viewed over its entire spectrum appears, however, to be one important physiologic cutaneous mechanism that rids the skin of undesirable or dangerous material. It may have significant public health implications when one considers the elimination of potentially infectious organisms as recorded in chromomycosis, 19,20 blas‐tomycosis, 21,22 cryptococcosis, 23 or tuberculosis 5…”