Transepidermal elimination of nevus cells. A possible mechanism of nevus involution

Kantor, G. R.

doi:10.1001/archderm.123.10.1371

Cited by 10 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Involution via regression can be identified with dermoscopy as regression structures, namely granularity and white scar-like areas; dermoscopic regression has been shown to correlate on histopathology with presence of melanophages and fibroplasias of the superficial dermis. Trans-epidermal elimination of melanocytic nests and apoptosis of melanocytes are other speculated mechanisms of nevus involution (Kantor and Wheeland, 1987; lee et al, 2000). We did not observe a halo phenomenon or regression structures at baseline in nevi that subsequently disappeared.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Dermoscopic Stability and Volatility of Melanocytic Nevi in a Population-Based Cohort of Children in Framingham School System

Scope

Dusza

Marghoob

et al. 2011

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Nevi are important risk markers of melanoma. The study aim was to describe changes in nevi of children using longitudinal data from a population-based cohort. Overview back photography and dermoscopic imaging of up to 4 index back nevi was performed at age 11 (baseline) and repeated at age 14 (follow-up). Of 443 children (39% females) imaged at baseline, 366 children (39% females) had repeated imaging three year later. At age 14, median back nevus counts increased by 2; 75% of students (n=274) had at least one new back nevus and 28% (n=103) had at least one nevus that disappeared. Of 936 index nevi imaged dermoscopically at baseline and follow-up, 69% (645 nevi) had retained the same dermoscopic classification from baseline evaluation. Only 4% (n=13) of nevi assessed as globular at baseline were classified as reticular at follow-up, and just 3% (n=3) of baseline reticular nevi were classified as globular at follow-up. Of 9 (1%) index nevi that disappeared at follow-up, none showed halo or regression at baseline. In conclusion, the relative stability of dermoscopic pattern of individual nevi in the face of the overall volatility of nevi during adolescence suggests that specific dermoscopic patterns may represent distinct biologic nevus subsets.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and Dermoscopic Stability and Volatility of Melanocytic Nevi in a Population-Based Cohort of Children in Framingham School System

Scope

Dusza

Marghoob

et al. 2011

Journal of Investigative Dermatology

View full text Add to dashboard Cite

show abstract

“…These areas become populated with excess cells. 60 Most believe that congenital nevi migrate in an upward fashion. [61][62][63] Barnhill et al 64 have suggested that CMN may be the result of extravascular migration of neural crest cells.…”

Section: Inheritance Key Pointmentioning

confidence: 99%

Congenital melanocytic nevi: Where are we now?

Alikhan

Ibrahimi

Eisen

2012

Journal of the American Academy of Dermatology

129

View full text Add to dashboard Cite

“…But this process has been described in benign and malignant melanocytic tumors too. 15,16 In this study, the finding of melanophages within the epidermis was significantly associated with Spitz nevi (p < 0.0001) and atypical Spitz tumors (p = 0.0152); a significant association between IEM and intracorneal melanocytes was observed in the Spitz nevi (p = 0.0154). Recently, the potential for spontaneous involution of Spitz nevi has been emphasized.…”

Section: Discussionmentioning

confidence: 47%

Melanocytic tumors with intraepidermal melanophages: a report of five cases with review of 231 archived cutaneous melanocytic tumors

et al. 2015

View full text Add to dashboard Cite

Dermal melanophages are frequently encountered in both benign melanocytic nevi and malignant melanoma. In contrast, intraepidermal melanophages (IEM) are under-recognized in melanocytic lesions and their biologic significance is not understood. Herein, we report the clinical and histopathologic features of five melanocytic lesions featuring IEM encountered prospectively in our dermatopathology practice at the University of Chicago. Two hundred and thirty-one (231) archived skin primary melanocytic proliferations were also investigated retrospectively in a de-identified, archival teaching set collection. Nineteen of 231 of the archived cases were positive for IEM. Among the total 24 IEM-positive cases (5 prospective and 19 archived cases), 13 were categorized as Spitz nevi (p < 0.0001) and 3 as atypical Spitz tumors (p = 0.0152). Fourteen of 24 cases with IEM also exhibited intracorneal melanocytes (p < 0.0001). IEM are evidently not rare, especially in spitzoid melanocytic neoplasms. IEM in our series were significantly correlated with intracorneal melanocytosis, possibly indicating an association between IEM and suprabasal melanocytosis and/or transepidermal elimination of melanocytes.

show abstract

Transepidermal elimination of nevus cells. A possible mechanism of nevus involution

Cited by 10 publications

References 0 publications

Clinical and Dermoscopic Stability and Volatility of Melanocytic Nevi in a Population-Based Cohort of Children in Framingham School System

Clinical and Dermoscopic Stability and Volatility of Melanocytic Nevi in a Population-Based Cohort of Children in Framingham School System

Congenital melanocytic nevi: Where are we now?

Melanocytic tumors with intraepidermal melanophages: a report of five cases with review of 231 archived cutaneous melanocytic tumors

Contact Info

Product

Resources

About