Transdermal behaviour of the N-alkylamide spilanthol (affinin) from Spilanthes acmella (Compositae) extracts

Boonen, Jente; Baert, Bram; Roche, Nathalie; Burvenich, Christian; Spiegeleer, Bart De

doi:10.1016/j.jep.2009.09.046

Cited by 71 publications

(51 citation statements)

References 61 publications

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“…25) and can possess an epoxy-derivative in its acid chain (27) (Bohlmann et al, 1980). In addition, this epoxy group was identified with a PEA residue in Spilanthes acmella, radicans and ciliata and in Salmea scandens (12) (Bohlmann et al, 1985;Boonen et al, 2010;Martin and Becker, 1985;Rios-Chavez et al, 2003). Globally, C 8 -C 14 IBAs, 2-MBAs and PEAs are documented in the Spilanthes genus.…”

Section: Plant Familiesmentioning

confidence: 98%

“…Due to these secondary metabolites, several plants have been used traditionally for organoleptic, as well as medical purposes, like toothache, gum, skin and gastric diseases, sexual dysfunctions and viral infections (Barnes et al, 2005;Boonen et al, 2010;Sharma et al, in press;Wang et al, 2007;Wu et al, 2004;Yang, 2008). These different uses reflect the wide variety of ethnopharmacological viewpoints: NAA containing plants are used in numerous Traditional medicine systems (TMS) all over the world.…”

Section: Introductionmentioning

confidence: 99%

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Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

130

109

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a b s t r a c tEthnopharmacological relevance: N-Alkylamides (NAAs) are a promising group of bioactive compounds, which are anticipated to act as important lead compounds for plant protection and biocidal products, functional food, cosmeceuticals and drugs in the next decennia. These molecules, currently found in more than 25 plant families and with a wide structural diversity, exert a variety of biologicalpharmacological effects and are of high ethnopharmacological importance. However, information is scattered in literature, with different, often unstandardized, pharmacological methodologies being used. Therefore, a comprehensive NAA database (acronym: Alkamid) was constructed to collect the available structural and functional NAA data, linked to their occurrence in plants (family, tribe, species, genus). Materials and methods: For loading information in the database, literature data was gathered over the period 1950-2010, by using several search engines. In order to represent the collected information about NAAs, the plants in which they occur and the functionalities for which they have been examined, a relational database is constructed and implemented on a MySQL back-end. Results: The database is supported by describing the NAA plant-, functional-and chemical-space. The chemical space includes a NAA classification, according to their fatty acid and amine structures. Conclusions: The Alkamid database (publicly available on the website http://alkamid.ugent.be/) is not only a central information point, but can also function as a useful tool to prioritize the NAA Q8 choice in the evaluation of their functionality, to perform data mining leading to quantitative structure-property relationships (QSPRs), functionality comparisons, clustering, plant biochemistry and taxonomic evaluations.

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Section: Plant Familiesmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

130

109

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“…Biological properties of A. oleraceae mainly depend on Nalkylamides, specially on spilanthol, the principal bioactive compound which showed important bioactivities such as antioxidant, anti-inflammatory, or diuretic activity and oral health care (it has traditionally been used for the treatment of toothache (Boonen et al, 2010). Other important phytochemicals in this species include alkaloids, flavonoids, saponins, steroid glycosides and tannins, which were all detected in the three main parts (leaf, stem and flower) of A. oleraceae.…”

Section: Acmella Oleraceae Murrmentioning

confidence: 99%

Asteraceae species with most prominent bioactivity and their potential applications: A review

Bessada

Barreira

Oliveira

2015

Industrial Crops and Products

125

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a b s t r a c tOxidative stress has a relevant part in the etiology of several diseases and metabolic disorders, being reasonable to expect that antioxidant compounds might have beneficial effects in health maintenance or disease prevention. Antioxidant compounds might be isolated and characterized from different plant constituents, such as roots, stems, bark, leaves, flowers, fruits and seeds, using proper extraction methods. The Asteraceae family has a worldwide distribution, with special relevance in the Mediterranean, Eastern Europe and Asia Minor, being acknowledged about 25 000 species integrated in approximately 1000 genera. In addition to the anti-inflammatory, analgesic and antipyretic potential of some of these species, their high antioxidant power, as proven in research works with extracts (of roots, stems, bark, leaves, flowers, fruits and seeds) should be highlighted. Herein, the Asteraceae species with highest potential as sources of natural antioxidants with potential uses in medicine and in pharmaceutical, cosmetic and food industries were identified. The species were selected based on their botanical representativeness, being identified the 9 most relevant species: Achillea millefolium L., Acmella oleraceae Murr., Artemisia absinthium L., Bidens pilosa L., Carthamus tinctorius L., Inula crithmoides L., Matricaria recutita L., Otanthus maritimus L. and Parthenium hysterophorus L.. With the obtained information, it could be concluded that the bioactivity of the selected Asteraceae species lacks a complete characterization, constituting a research scope with great potential to be exploited in the development of dietary supplements, bioactive food ingredients or pharmaceutical based products with application in food industry, dermocosmetics or medicine.

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“…Moreover, the extract is traditionally added to the nutritional and cosmetic supplement to accelerate the process of recovery of skin damaged by vasoconstriction (BOONEN et al, 2010b;PRACHAYASITTIKUL et al, 2013). Pharmacologically, S. oleracea L. is a potential vasodilator, antioxidant (WONGSAWATKUL et al, 2008) and immunomodulator (SAVADI et al, 2010).…”

Section: Biological Activitiesmentioning

confidence: 99%

Jambu drying with cold air circulation

et al. 2015

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Transdermal behaviour of the N-alkylamide spilanthol (affinin) from Spilanthes acmella (Compositae) extracts

Cited by 71 publications

References 61 publications

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Asteraceae species with most prominent bioactivity and their potential applications: A review

Jambu drying with cold air circulation

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