Transcutaneous electrical acupoint stimulation for suspected laryngopharyngeal reflux disease

Shen, Hailong; Han, Yanxun; Yao, Changyu; Tao, Ye; Wu, Jing; Gao, Chaobing; Wu, Feihu; Liu, Yehai

doi:10.1007/s00405-022-07698-9

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…In treatment using acupuncture for postoperative chronic cough in patients with non-small cell lung cancer lung cancer, the study showed that the Leicester cough score (Leicester cough questionnaire [LCQ]) in the acupuncture treatment group 10 weeks after surgery was significantly higher than the group with no treatment [ 63 ]. In the latest study, Shen et al [ 64 ] effectively cured chronic cough in a prospective, randomized, controlled trial. In addition, studies have shown that pain stimulation in healthy subjects reduces cough and cough impulsivity [ 65 ].…”

Section: Composition Of Non-pharmacologic Therapymentioning

confidence: 99%

Management of non-pharmacologic therapy for chronic refractory cough: Mechanism, composition, applicable population, and assessment

Peng,

Zhang,

Yuan

et al. 2023

Heliyon

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Section: Composition Of Non-pharmacologic Therapymentioning

confidence: 99%

Management of non-pharmacologic therapy for chronic refractory cough: Mechanism, composition, applicable population, and assessment

Peng,

Zhang,

Yuan

et al. 2023

Heliyon

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“…Therefore, there is a need for exploring complementary and alternative medicine (CAM) as a treatment for LPRD. A recent study found that transcutaneous electrical acupoint stimulation (TEAS) combined with PPI showed a significantly greater improvement in LPRD symptoms ( Shen et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Integrative effects of transcutaneous auricular vagus nerve stimulation on esophageal motility and pharyngeal symptoms via vagal mechanisms in patients with laryngopharyngeal reflux disease

Huang,

Liu,

et al. 2024

Front. Neurosci.

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Background and aimLaryngopharyngeal reflux disease (LPRD) is primarily characterized by discomfort in the pharynx and has limited treatment options. This research aimed to assess the efficacy of transcutaneous auricular vagus nerve stimulation (tVNS) in patients with LPRD and delve into the potential underlying mechanisms.MethodsA total of 44 participants, diagnosed with LPRD were divided into two groups randomly. Twice-daily stimulation was delivered for 2 weeks for patients in experimental group, with stimulation ranging from 1.0 mA to 1.5 mA (n = 22), while the control group underwent sham tVNS (n = 22) with the same stimulation parameters and different anatomical location. The severity of symptoms and levels of anxiety and depression were monitored using questionnaires. High-resolution esophageal manometry data were collected, and the patients’ autonomic function was assessed through heart rate variability analysis.ResultsThere was a positive correlation between reflux symptom index (RSI) scores and low frequency/high frequency (LF/HF) ratio (r = 0.619; p < 0.001), Hamilton anxiety scale (HAMA) scores (r = 0.623; p < 0.001), and Hamilton depression scale (HAMD) scores (r = 0.593; p < 0.001). Compared to the pre-tVNS phase, RSI (p < 0.001), HAMA (p < 0.001), and HAMD (p < 0.001) scores were significantly reduced after 2 weeks of treatment. Additionally, the resting pressure of the upper esophageal sphincter (UESP; p < 0.05) and lower esophageal sphincter (LESP; p < 0.05) showed significant enhancement. Notably, tVNS led to an increase in root mean square of successive differences (RMSSD; p < 0.05) and high frequency (HF; p < 0.05) within heart rate variability compared to the pre-treatment baseline. Compared to the control group, RSI (p < 0.001), HAMA (p < 0.001), and HAMD (p < 0.001) scores in tVNS group were significantly lower at the end of treatment. Similarly, the resting pressure of UESP (p < 0.05) and LESP (p < 0.05) in tVNS group were significantly higher than that of control group. Notably, RMSSD (p < 0.05) and HF (p < 0.05) in tVNS group were significantly higher than that of control group.ConclusionThis study demonstrated that tVNS as a therapeutic approach is effective in alleviating LPRD symptoms. Furthermore, it suggests that improvements in esophageal motility could be associated with vagus nerve-dependent mechanisms.

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Transcutaneous electrical acupoint stimulation, autonomic nerve dysfunction and laryngopharyngeal reflux

Lechien

Cheikh-Youssef

Maniaci

et al. 2022

Eur Arch Otorhinolaryngol

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Transcutaneous electrical acupoint stimulation for suspected laryngopharyngeal reflux disease

Cited by 4 publications

References 45 publications

Management of non-pharmacologic therapy for chronic refractory cough: Mechanism, composition, applicable population, and assessment

Management of non-pharmacologic therapy for chronic refractory cough: Mechanism, composition, applicable population, and assessment

Integrative effects of transcutaneous auricular vagus nerve stimulation on esophageal motility and pharyngeal symptoms via vagal mechanisms in patients with laryngopharyngeal reflux disease

Transcutaneous electrical acupoint stimulation, autonomic nerve dysfunction and laryngopharyngeal reflux

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