Transcriptomic responses to heat stress and nickel in the mussel Mytilus galloprovincialis

Reduced stress defence responses contribute to the higher toxicity of a pesticide under warming

“…These antagonistically upregulated general stress defence responses based on Sulmon et al (2015) are a subset of DEGs from Table 1 with DEGs related to protection of macromolecules, antioxidant processes, detoxification and energy metabolism/allocation. Similar to our results, Mediterranean mussels (Mytilus galloprovincialis, Lamarck, 1819) exposed to nickel under 8°C warming also showed a decreased upregulation of heat shock protein genes compared to when exposed to only 8°C warming (Banni et al, 2014). In the DEG set based on Sulmon et al (2015), additive DEGs were also common, and only one DEG showed a synergistic downregulation when exposed to the high-effect chlorpyrifos concentration under warming.…”

“…Only three studies have investigated gene expression responses related to the CITS concept, all focusing on the higher toxicity of metals (Banni et al, 2014;Negri et al, 2013) and of an aromatic ketone (Muñiz-González & Martínez-Guitarte, 2020) under warming. While very insightful, these studies did not explicitly consider interaction effects at the gene expression level.…”

The Role of Temperature on the Impact of Remediated Water towards Marine Organisms

“…Although recent literature has demonstrated the impacts of temperature in bivalves physiological and biochemical performance, the co-occurrence of temperature increase and pollutants is not yet well understood. The simultaneous occurrence of temperature rise and the presence of pollutants may result in organisms increased sensitivity to each of the stressors but may also alter pollutants' toxicity, leading to additive or antagonist effects as reported in several studies [23,28,29,47,[72][73][74]. According to Coppola et al [21], oxidative stress was enhanced in M. galloprovincialis exposed to Hg under warming conditions.…”

Predicting growth and mortality of bivalve larvae using gene expression and supervised machine learning

“…For example, two ganglioside gm2 activator (GM2A) homologues (-a and -b in Table 4) were also associated with hyperlipidosis syndrome of chemically exposed adult mussels (Dondero et al, 2011). For example, the GM2A was induced in benzo[a]pyrene-treated adult mussels (Brown et al, 2006), involved in lipid metabolism in adult hypoxic oysters (Sussarellu et al, 2010) and nickel-or heat-stressed mussels (Mohamed et al, 2014). These GM2As were both oppositely expressed in 17β-Estradiol treated adult mussels (Canesi et al, 2004).…”