2017
DOI: 10.18632/aging.101321
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Abstract: Chronic low grade inflammation is a fundamental mechanism of aging. We estimated biologic age using nine biomarkers from diverse inflammatory pathways and we hypothesized that genes associated with inflammatory biological age would provide insights into human aging. In Framingham Offspring Study participants at examination 8 (2005 to 2008), we used the Klemera-Doubal method to estimate inflammatory biologic age and we computed the difference (ΔAge) between biologic age and chronologic age. Gene expression in w… Show more

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Cited by 12 publications
(11 citation statements)
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References 51 publications
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“…It uses a small set of individuals with both genotype and gene expression data as a reference panel to identify signi cant expression-trait associations. Through extensive simulations of available GWAS data, TWAS identi ed candidate genes associated with, schizophrenia [8], calci c aortic valve stenosis [9], nonobstructive azoospermia [10], in ammatory biologic age [11] and other complex traits [12,13]. Meanwhile, the genetic susceptibility variants associated with RA commonly map to enhancer regions [14], which can regulate one or more genes at distant locations in a cell-type-speci c manner.…”
Section: Gene Expression Is An Intermediate Phenotype Between Geneticmentioning
confidence: 99%
“…It uses a small set of individuals with both genotype and gene expression data as a reference panel to identify signi cant expression-trait associations. Through extensive simulations of available GWAS data, TWAS identi ed candidate genes associated with, schizophrenia [8], calci c aortic valve stenosis [9], nonobstructive azoospermia [10], in ammatory biologic age [11] and other complex traits [12,13]. Meanwhile, the genetic susceptibility variants associated with RA commonly map to enhancer regions [14], which can regulate one or more genes at distant locations in a cell-type-speci c manner.…”
Section: Gene Expression Is An Intermediate Phenotype Between Geneticmentioning
confidence: 99%
“…It uses a small set of individuals with both genotype and gene expression data as a reference panel to identify significant expression-trait associations. Through extensive simulations of available GWAS data, TWAS identified candidate genes associated with, schizophrenia [ 8 ], calcific aortic valve stenosis [ 9 ], nonobstructive azoospermia [ 10 ], inflammatory biologic age [ 11 ], and other complex traits [ 12 , 13 ]. Meanwhile, the genetic susceptibility variants associated with RA commonly map to enhancer regions [ 14 ], which can regulate one or more genes at distant locations in a cell-type-specific manner.…”
Section: Introductionmentioning
confidence: 99%
“…For example, a TWAS about 3000 subjects found 69 novel genes signi cantly related to BMI, lipids, and height which have a bearing on obesity [9]. A TWAS about Chronic low-grade in ammation recognized 448 genes related to in ammatory biologic age [10].…”
Section: Introductionmentioning
confidence: 99%