volume 7, issue 6, P389-411 2015
DOI: 10.18632/aging.100755
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Jenny S. Breitenbach, Mark Rinnerthaler, Andrea Trost, Manuela Weber, Alfred Klausegger, Christina Gruber, Daniela Bruckner, Herbert A. Reitsamer, Johann W. Bauer, Michael Breitenbach

Abstract: The aging process of skin has been investigated recently with respect to mitochondrial function and oxidative stress. We have here observed striking phenotypic and clinical similarity between skin aging and recessive dystrophic Epidermolysis bullosa (RDEB), which is caused by recessive mutations in the gene coding for collagen VII, COL7A1. Ultrastructural changes, defects in wound healing, and inflammation markers are in part shared with aged skin. We have here compared the skin transcriptomes of young adults …

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