2005
DOI: 10.1128/ec.4.12.2115-2128.2005
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Abstract: Paracoccidioides brasiliensis is a thermodimorphic fungus associated with paracoccidioidomycosis (PCM), a systemic mycosis prevalent in South America. In humans, infection starts by inhalation of fungal propagules, which reach the pulmonary epithelium and transform into the yeast parasitic form. Thus, the mycelium-toyeast transition is of particular interest because conversion to yeast is essential for infection. We have used a P. brasiliensis biochip carrying sequences of 4,692 genes from this fungus to monit… Show more

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Cited by 110 publications
(134 citation statements)
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“…In both cases molecular regulation is still poorly understood and few studies had reported genes that could possibly be involved in both processes (12,14,18).…”
Section: Discussionmentioning
confidence: 99%
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“…In both cases molecular regulation is still poorly understood and few studies had reported genes that could possibly be involved in both processes (12,14,18).…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have reported the over-expression of genes involved in diverse cellular pathways during the mycelium to yeast transition in P. brasiliensis, including metabolism, signal transduction, energy, protein and fat synthesis, cellular transport, biogenesis of cellular components, cell wall and membrane remodeling and genes encoding putative virulence factors (11)(12)(13). Additionally, in a study on the conidium to yeast transition process, some genes were expressed after 48 hours on transition and shown to be involved in different biologic processes such as metabolism, cell wall synthesis and signal transduction: some of these were considered specific for this process (14).…”
mentioning
confidence: 99%
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“…Remodelling of the cell wall during the fungal transition is reflected in the transcriptional analysis by the over-expression, for example, of the genes encoding chitinase 1 (CTS1) and 3 (CTS3), as well as UDP-N-acetyl glucosamine transporter, which putatively provides Nacetyl glucosamine for the synthesis of chitin. Thus, microarray hybridization analysis identified the up-regulation of a series of genes encoding enzymes related to the changes in fungal surface in P. brasiliensis, isolate Pb18 (Nunes et al 2005).…”
Section: The Most Prominent Metabolic Pathways Induced During the Dimmentioning
confidence: 99%
“…Os avanços na caracterização de adesinas de P. brasiliensis têm sido obtidos com os estudos de transcriptoma (FELIPE et al, 2003;FELIPE et al, 2005;NUNES et al, 2005 Ultimamente, muitas técnicas estão sendo desenvolvidas para identificar a expressão diferencial de um gene. Uma destas técnicas é o RDA (Representational Difference Analysis), que em sua forma original foi designado para identificar diferenças entre populações de DNA genômico (LISITSYN et al, 1993).…”
Section: ) E Coccidioides Immitisunclassified