2018
DOI: 10.18632/aging.101441
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Abstract: E2F is a group of genes that encode a family of transcription factors (TFs) in higher eukaryotes and participate in cell cycle regulation and DNA synthesis in mammalian cells. Evidence from cell lines, mouse models, and human tissues indicates that TFs are implicated in lung cancer (LC) tumorigenesis. However, the diverse expression patterns and prognostic values of eight E2Fs have yet to be elucidated. In the current study, we examined the transcriptional and survival data of E2Fs in patients with LC from ONC… Show more

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Cited by 64 publications
(60 citation statements)
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References 54 publications
(65 reference statements)
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“…A recent study showed that E2F4 overexpression in the nuclei of breast cancer cells was associated with various advanced clinicopathological features and a poor clinical prognosis in breast cancer patients (51). Sun et al reported that high E2F4 expression was signi cantly associated with poor OS, FP and PPS in lung cancer patients (52), while in digestive tract tumors, E2F4 was found to promote the development of liver cancer, colorectal cancer and gastric cancer (10). In our study, high expression of E2F4 was associated with a poor prognosis in gastric cancer patients.…”
Section: Discussionsupporting
confidence: 56%
“…A recent study showed that E2F4 overexpression in the nuclei of breast cancer cells was associated with various advanced clinicopathological features and a poor clinical prognosis in breast cancer patients (51). Sun et al reported that high E2F4 expression was signi cantly associated with poor OS, FP and PPS in lung cancer patients (52), while in digestive tract tumors, E2F4 was found to promote the development of liver cancer, colorectal cancer and gastric cancer (10). In our study, high expression of E2F4 was associated with a poor prognosis in gastric cancer patients.…”
Section: Discussionsupporting
confidence: 56%
“…The results of GSE10846 and GSE53786 further confirmed the results that high expression of ORMDL1 indicated poor prognosis in DLBCL patients. In addition, the cBioPortal database was used as a powerful tool for discovering ORMDL1 genetic alterations in DLBCL, since genetic alteration was considered as an important factor in cancer development [ 45 , 46 ]. Expectedly, increased gene copies and slight gene deletion existed in DLBCL, which partly explained the higher expression of ORMDL1 in DLBCL compared with normal samples.…”
Section: Discussionmentioning
confidence: 99%
“…The transcription factors E2F family were reported in the regulation of cell cycle and apoptosis [3]. Some of them could activate the quiescent cells from G phase to S phase [21] and they might be the indispensable and determant factor for the survival of CRC cells, as E2F knockdown slows down the G /S transition and the prolifration rate of human intestinal epithelial cells [22]. In spite of this, survival analysis of CRC patients with bioinformatic tools has not been widely reported so far.…”
Section: Discussionmentioning
confidence: 99%