Transcriptional Activity of Some Genes Involved in Apoptosis in Patients with Vulvar Lichen Sclerosus

Klimov, Eugene; Соболев, В. В.; Batashkov, N A; Кокаева, З.Г.; Tretiakov, Artemii; Nevozinskaya, Z. A.; Korsunskaya, I. M.; Сухова, Т Н; Evina, O E; Хашукоева, А. З.

doi:10.1007/s10517-022-05467-6

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“…HLADQB10201 can make vulva tissue susceptible to stimulation and promote the occurrence of vulvar diseases (11,12). A decrease in the expression of HLADQB10201 can avoid the onset of vulva diseases; thus, this disorder may be associated with an imbalance in these genes (13).…”

Section: Discussionmentioning

confidence: 99%

Comparison of electrophysiology therapy and glucocorticoid therapy in the treatment of 2 subtypes of vulvar epithelial non-neoplastic lesions: a prospective cohort study

Wei¹,

Li²,

Zhang³

et al. 2023

Ann Transl Med

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Background: Lichen-like lesions with degeneration and pigmentation alterations can be divided into the following 2 types: (I) chronic simple lichen; and (II) sclerosing lichen. The etiology of the disease is unknown. This study sought to examine the therapeutic effects of electrophysiological smooth-muscle electrical stimulation in the treatment of lichen-like lesions of the vulva.Methods: A total of 80 outpatients, who had been confirmed to have vulvar lichen-like lesions by vulvar biopsy at our hospital from November 2016 to March 2018, were prospectively included in this study. The patients received electrophysiology or glucocorticoid therapy. After completing a treatment cycle according to the clinical treatment routine, the outpatients were monitored at 1-, 3-and 6-month intervals. Patients used an improvement scale (i.e., the patient global impression of change scale) to score their subjective perceptions and subjective symptoms. The clinical curative effect scale was used to calculate the curative effect index and grade the curative effect.Results: After 1 month of treatment, the active enhancement of simple lichen in the electrophysiological treatment group and glucocorticoid treatment group improved, while the active enhancement of simple lichen in the electrophysiological treatment group improved after 3 months of treatment. After 6 months of treatment, the subjective improvement score of the electrophysiological treatment group was better than that of lichen sclerosus. After 3 months of treatment, the effective rate of the electrophysiological therapy group was better than that of the glucocorticoid therapy group. After 6 months of treatment in the electrophysiological treatment group, the efficacy of simple lichen is also better than that of sclerotic lichen.Conclusions: Conventional hormone therapy is easier for patients to accept because of its convenience and low costs.

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Section: Discussionmentioning

confidence: 99%