Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: A double-blind placebo-controlled study

Rumi, Demétrio Ortega; Gattaz, Wagner F.; Rigonatti, Sergio P.; Rosa, Moacyr Alexandro; Fregni, Felipe; Rosa, Marina Odebrecht; Mansur, Carlos Gustavo; Myczkowski, Martin Luiz; Moreno, Ricardo Alberto; Marcolin, Marco Antônio

doi:10.1016/j.biopsych.2004.10.029

Cited by 187 publications

(134 citation statements)

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“…When this current is applied repetitively, repetitive transcranial magnetic stimulation (rTMS), it can modulate cortical excitability, decreasing or increasing it, depending on the parameters of stimulation. Since its inception, researchers have proposed the use of TMS and rTMS to study and treat neuropsychiatric diseases, such as major depression George et al 2000;Martin et al 2003;Holtzheimer et al 2004;Rumi et al 2005), schizophrenia (Hoffman et al 2003;Lee et al 2005), Parkinson's disease (Mally and Stone 1999;de Groot et al 2001;Khedr et al 2003;Fregni et al 2004;Lefaucheur et al 2004), dystonia (Huang et al 2004), epilepsy (Tergau et al 1999;Menkes and Gruenthal 2000;Daniele et al 2003;Fregni et al 2005) and the acute or chronic sequels derived from stroke ). However, a fundamental question that needs to be addressed before the wide-spread use of TMS in clinical practice, is how the modification of brain anatomy and tissue properties caused by certain neuropsychiatric diseases can alter the effects of TMS.…”

Section: Introductionmentioning

confidence: 99%

“…The main reason for this perturbation is that the altered distribution of cerebral spinal fluid (CSF) to brain tissue modifies the conductive tissue properties in the infarction region and effectively provides a path of lowered resistance for the stimulating currents to flow along. Several diseases explored or treated with TMS, such as depression George et al 2000;Martin et al 2003;Holtzheimer et al 2004;Rumi et al 2005), Alzheimer's disease (Alagona et al 2004;Pierantozzi et al 2004), Huntington's disease (Modugno et al 2001), corticobasal degeneration (Kuhn et al 2004) and CreutzfeldtJakob's disease (Sakuishi et al 2005), as well as normal aging (Sowell et al 2003), show related anatomical changes that could have an impact on the TMS induced electric currents. All of these populations are characterized by varying degrees of cortical atrophy, where brain tissue is replaced by CSF, the CSF to cortical tissue volume ratios increase, and oftentimes the cerebral sulci widen.…”

Section: Introductionmentioning

confidence: 99%

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Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study

et al. 2008

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This paper is aimed at exploring the effect of cortical brain atrophy on the currents induced by transcranial magnetic stimulation (TMS). We compared the currents induced by various TMS conditions on several different MRI derived finite element head models of brain atrophy, incorporating both decreasing cortical volume and widened sulci. The current densities induced in the cortex were dependent upon the degree and type of cortical atrophy and were altered in magnitude, location, and orientation when compared to healthy head models. Predictive models of the degree of current density attenuation as a function of the scalp-to-cortex distance were analyzed, concluding that those which ignore the electromagnetic field-tissue interactions lead to inaccurate conclusions. Ultimately, the precise site and population of neural elements stimulated by TMS in an atrophic brain cannot be predicted based on healthy head models which ignore the effects of the altered cortex on the stimulating currents. Clinical applications of TMS should be carefully considered in light of these findings.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study

et al. 2008

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“…A few studies tested the use of rTMS as an accelerating therapy, i.e., the use of rTMS to hasten an antidepressant response -in this type of trial, active or sham rTMS starts simultaneously with a pharmacological treatment -3 of 4 studies showed that the active rTMS fastened drug response. The drugs tested were venlafaxine, escitalopram or sertraline 64 ; amitriptyline 65 ; escitalopram 66 ; mirtazapine or venlafaxine 67 -the last trial, however, showed a negative response.…”

Section: Efficacy Of Rtms In Acute Mddmentioning

confidence: 99%

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Brunoni

Teng

Correa³

et al. 2010

Arq. Neuro-Psiquiatr.

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The use of neuromodulation as a treatment for major depressive disorder (MDD) has recently attracted renewed interest due to development of other non-pharmacological therapies besides electroconvulsive therapy (ECT) such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), and vagus nerve stimulation (VNS). Method: We convened a working group of researchers to discuss the updates and key challenges of neuromodulation use for the treatment of MDD. results: The state-of-art of neuromodulation techniques was reviewed and discussed in four sections: [1] epidemiology and pathophysiology of MDD; [2] a comprehensive overview of the neuromodulation techniques; [3] using neuromodulation techniques in MDD associated with non-psychiatric conditions; [4] the main challenges of neuromodulation research and alternatives to overcome them. Discussion: ECT is the first-line treatment for severe depression. TMS and tDCS are strategies with a relative benign profile of side effects; however, while TMS effects are comparable to antidepressant drugs for treating MDD; further research is needed to establish the role of tDCS. DBS and VNS are invasive strategies with a possible role in treatment-resistant depression. In summary, MDD is a chronic and incapacitating condition with a high prevalence; therefore clinicians should consider all the treatment options including invasive and non-invasive neuromodulation approaches. Key words: comprehensive review, major depressive disorder, ECT, TMS, clinical guidelines.Estratégias de neuromodulação para o tratamento da depressão maior: desafios e recomendações de uma força-tarefa rEsuMo O uso de técnicas de neuromodulação para o tratamento do transtorno depressivo maior (TDM) tem despertado um renovado interesse nos últimos anos com o desenvolvimento de outras intervenções não-farmacólogicas além da eletroconvulsoterapia (ECT), como a estimulação magnética transcraniana (EMT), a estimulação transcraniana por corrente continua (ETCC), a estimulação cerebral profunda (DBS) e a estimulação de nervo vago (VNS). Método: Nós organizamos um grupo de trabalho com vários pesquisadores para discutir os avanços recentes e os principais desafios para o uso da neuromodulação no tratamento os principais desafios da pesquisa na neuromodulação e alternativas para superá-los. Discussão: ECT é o tratamento de primeira linha para depressão grave. EMT e ETCC são estratégias com um perfil benigno de efeitos adversos; contudo, enquanto os efeitos da EMT são comparáveis ao das drogas antidepressivas para o tratamento da TDM, a eficácia da ETCC ainda precisa ser estabelecida por mais pesquisas clínicas. DBS e VNS são intervenções invasivas com um papel possível para a depressão refratária. Em resumo, TDM é uma condição crônica, incapacitante e de alta prevalência; portanto na prática clínica todas as opções de tratamento possíveis, incluindo as farmacológicas e não-farmacológicas, devem ser consideradas. Palavras-chave: artigo de revisão, tra...

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“…Les données de la littérature démontrent l'excellente tolérance de cette méthode d'investigation [12]. Plusieurs études randomisées ont montré une efficacité thérapeutique de la TMS dans les troubles de l'humeur [7,8,12,15]. Huit méta-analyses sur neuf ont montré une efficacité de la TMS dans la dépression [5,14].…”

Section: Introductionunclassified

Intérêt de la TMS au long cours au sein d’une population de patients âgés déprimés résistants

Januel¹,

Benadhira²,

Braha³

et al. 2010

Annales Médico-psychologiques, revue psychiatrique

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Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: A double-blind placebo-controlled study

Cited by 187 publications

References 16 publications

Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study

Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Intérêt de la TMS au long cours au sein d’une population de patients âgés déprimés résistants

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