Transcranial Direct Current Stimulation to Primary Motor Area Improves Hand Dexterity and Selective Attention in Chronic Stroke

Au-Yeung, Stephanie S.Y.; Wang, Juliana; Chen, Ye; Chua, Eldrich Norwin

doi:10.1097/phm.0000000000000127

Cited by 37 publications

(30 citation statements)

References 35 publications

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“…In the absence of published data on this topic, the statistical outcomes of this study can serve in understanding and guiding the therapies of altered dexterity in MS patients. Previous tDCS studies addressing dexterity in stroke patients adopted sample sizes between 10 and 19 and yielded statistical significance [59,60].…”

Section: Sample Size Randomization and Blinding Effectivenessmentioning

confidence: 99%

Effects of Transcranial Direct Current Stimulation on Hand Dexterity in Multiple Sclerosis: A Design for a Randomized Controlled Trial

et al. 2020

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Background: Cerebellar and motor tracts are frequently impaired in multiple sclerosis (MS). Altered hand dexterity constitutes a challenge in clinical practice, since medical treatment shows very limited benefits in this domain. Cerebellar control is made via several cerebellocortical pathways, of which the most studied one links the cerebellum to the contralateral motor cortex via the contralateral ventro-intermediate nucleus of the thalamus influencing the corticospinal outputs. Modulating the activity of the cerebellum or of the motor cortex could be of help. Method: The main interest here is to evaluate the efficacy of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, in treating altered dexterity in MS. Forty-eight patients will be recruited in a randomized, double-blind, sham-controlled, and crossover study. They will randomly undergo one of the three interventions: anodal tDCS over the primary motor area, cathodal tDCS over the cerebellum, or sham. Each block consists of five consecutive daily sessions with direct current (2 mA), lasting 20 min each. The primary outcome will be the improvement in manual dexterity according to the change in the time required to complete the nine-hole pegboard task. Secondary outcomes will include fatigue, pain, spasticity, and mood. Patients’ safety and satisfaction will be rated. Discussion: Due to its cost-effective, safe, and easy-to-use profile, motor or cerebellar tDCS may constitute a potential tool that might improve dexterity in MS patients and therefore ameliorate their quality of life.

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Section: Sample Size Randomization and Blinding Effectivenessmentioning

confidence: 99%

Effects of Transcranial Direct Current Stimulation on Hand Dexterity in Multiple Sclerosis: A Design for a Randomized Controlled Trial

et al. 2020

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“…Since tDCS is highly portable and safe, as well as economical, it can be used conveniently for the purposes of research and treatment3 ) . Previous studies have reported that providing tDCS to patients with stroke can help increase hand function, balance, and motor function in addition to improvements in cognition, such as executive function, concentration, short-term memory, and a reduction in depression4,5,6,7 ) . However, few studies have been conducted on the effect of tDCS on visual perception and performance of ADLs, which are important indices for improvement in the rehabilitation of patients with stroke.…”

Section: Introductionmentioning

confidence: 99%

Effect of transcranial direct current stimulation on visual perception function and performance capability of activities of daily living in stroke patients

Kim

2016

J Phys Ther Sci

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[Purpose] The purpose of this study was to examine the effects of transcranial direct current stimulation (tDCS) on visual perception and performance of activities of daily living in patients with stroke. [Subjects and Methods] Thirty subjects were assigned equally to a tDCS plus traditional occupational therapy group (experimental group) and a traditional occupational therapy group (control group). The intervention was implemented five times per week, 30 minutes each, for six weeks. In order to assess visual perception function before and after the intervention, the motor-free visual perception test (MVPT) was conducted, and in order to compare the performance of activities of daily living, the Functional Independence Measure scale was employed. [Results] According to the results, both groups improved in visual perception function and in performance of activities of daily living. Although there was no significant difference between the two groups, the experimental group exhibited higher scores. [Conclusion] In conclusion, the application of tDCS for the rehabilitation of patients with stroke may positively affect their visual perception and ability to perform activities of daily living.

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“…Research has already shown that anodic tDCS can benefit patients with chronic stroke 7 . A study in stroke survivors showed that anodic tDCS can also improve selective attention 15 . Also, tDCS application over time improved motor skill learning with a paretic upper limb and resulted in prolonged shaping of brain activation, which supported behavioral enhancements in stroke patients 16 .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, controversial findings in research have been reported about tDCS effects on post-stroke depression. For example, in two studies conducted by researchers, the positive effects of anodic tDCS in 522 and 141 patients with chronic stroke were studied; it was observed that the use of this method was able to create positive changes in attitude towards life and hope for life 3,15,16 . On the other hand, some studies of this group of patients who used anodic tDCS to reduce the negative effects of depression showed that this method was not able to produce specific and positive effects in reducing the complications of poststroke depression 17 .…”

Section: Introductionmentioning

confidence: 99%

Anodal transcranial direct current stimulation enhances positive changes in movement functions, visual attention and depression of patients with chronic ischemic stroke: A clinical trial

et al. 2018

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Introduction: Stroke is one of the most serious and debilitating diseases in our society. Stroke survivors can suffer several neurological impairments. They typically show pathological changes in neural functions of brain areas. Transcranial direct current stimulation (tDCS) can be applied to modify cerebral excitability and has been recently applied in the treatment of neuropsychological and neurological disorders. The aim of the study herein was to evaluate changes in movement and cognitive functions of chronic ischemic stroke patients using anodic and cathodic tDCS. Method: In this clinical trial, 100 patients with chronic ischemic stroke were divided in 4 groups (control, sham, anodic tDCS, and cathodic tDCS; n=25 per group). The patients underwent routine treatment and received the same tDCS protocol (3 times per week of 30-min sessions during one month). Movement and cognitive functions were evaluated using the NIHSS Scale & Trail Making Test and the Beck Test, before and after 1 and 3 months of tDCS sessions. All data were analyzed by 2-way repeated measures ANOVA using SPSS program (version 18). Results: The results showed that there were significant increases (P<0.001) in NIHSS score and Barthel index between anodic group versus control, sham, or cathodic group, at various timepoints (before vs. 1 month after tDCS, 1 month vs. 3 months after tDCS, and before vs. 3 months after tDCS). Furthermore, there were significant decreases (P<0.001) between anodic group versus control, sham, or cathodic group, at the various timepoints (before vs. 1 month after tDCS, 1 month vs. 3 months after tDCS, and before vs. 3 months after tDCS). Conclusion: Anodic tDCS has advantageous effects on movement and cognitive rehabilitation in stroke patients, but future studies are needed to further discern the differences and develop precise treatment protocols.

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Transcranial Direct Current Stimulation to Primary Motor Area Improves Hand Dexterity and Selective Attention in Chronic Stroke

Abstract: Twenty minutes of cathodal tDCS to M1nonlesioned can promote both paretic hand dexterity and selective attention in people with chronic stroke.

Cited by 37 publications

References 35 publications

Effects of Transcranial Direct Current Stimulation on Hand Dexterity in Multiple Sclerosis: A Design for a Randomized Controlled Trial

Effects of Transcranial Direct Current Stimulation on Hand Dexterity in Multiple Sclerosis: A Design for a Randomized Controlled Trial

Effect of transcranial direct current stimulation on visual perception function and performance capability of activities of daily living in stroke patients

Anodal transcranial direct current stimulation enhances positive changes in movement functions, visual attention and depression of patients with chronic ischemic stroke: A clinical trial

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