Transcranial Direct Current Stimulation Reduces Anxiety, Depression and Plasmatic Corticosterone in a Rat Model of Atypical Generalized Epilepsy

Gouveia, Flavia Venetucci; Germann, Jürgen; Oliveira, Caroline C. de; Castro, Marina Correia de; Antunes, Geiza Fernanda; Gomes, Grace Angélica de Oliveira; Pinto, Tais R.C.; Martinez, Raquel Chacon Ruiz; Valle, Angela C.

doi:10.1016/j.neuroscience.2021.11.003

Cited by 2 publications

(4 citation statements)

References 63 publications

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“…tDCS improved anxiodepressive-like behaviors in this rat model, suggesting promising future uses in MDD with comorbid conditions. Interestingly, plasma glucocorticoids decreased after successful treatment [20 ▪▪ ].…”

Section: Non-invasive Approachesmentioning

confidence: 98%

Neurostimulation as a treatment for mood disorders in patients: recent findings

Afshari

Belzung

2022

Current Opinion in Psychiatry

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Purpose of reviewThe use of neurostimulation to treat mood disorders dates back to the 1930s. Recent studies have explored various neurostimulation methods aimed at both restoring a healthy brain and reducing adverse effects in patients. The purpose of this review is to explore the most recent hypotheses and clinical studies investigating the effects of stimulating the brain on mood disorders.Recent findingsRecent work on brain stimulation and mood disorders has focused mainly on three aspects: enhancing efficacy and safety by developing new approaches and protocols, reducing treatment duration and chances of relapse, and investigating the physiological and pathological mechanisms behind treatment outcomes and possible adverse effects.This review includes some of the latest studies on both noninvasive techniques, such as transcranial magnetic stimulation, magnetic seizure therapy, transcranial direct current stimulation, transcranial alternating current stimulation, electroconvulsive treatment, and invasive techniques, such as deep brain stimulation and vagus nerve stimulation.SummaryBrain stimulation is widely used in clinical settings; however, there is a lack of understanding about its neurobiological mechanism. Further studies are needed to understand the neurobiology of brain stimulation and how it can be used to treat mood disorders in their diversity, including comorbidities with other illnesses.

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Section: Non-invasive Approachesmentioning

confidence: 98%

Neurostimulation as a treatment for mood disorders in patients: recent findings

Afshari

Belzung

2022

Current Opinion in Psychiatry

View full text Add to dashboard Cite

show abstract

“…J Physiol 602.14 models, Gouveia et al (2022) showed that tDCS exerts anxiolytic and anti-depressant effects in GEAS-W rats with reduction of plasma corticosterone levels. The authors suggest that tDCS can trigger neuroendocrine responses via the HPA axis, decreasing salivary cortisol levels (Gouveia et al, 2022). Interestingly, tDCS has been shown to improve autonomic control in neurological diseases and researchers have also been exploring the use of tDCS as a potential treatment to manage chronic cardiovascular conditions characterised by elevated sympathetic activity.…”

Section: Journal Clubmentioning

confidence: 99%

“…In fact, studies investigating the role of the PFC in regulating physiological responses induced by stress have been gaining interest from the scientific community, with data hinting at potential new approaches, including non‐invasive cortical stimulation, to manage physiological responses to stress. For instance, transcranial direct current stimulation (tDCS) is a safe neuromodulatory tool aimed at modulating dysfunctional circuits by applying weak direct currents over the scalp, increasing (anodal tDCS) or decreasing (cathodal tDCS) cortical excitability (Gouveia et al., 2022; Rodrigues et al., 2021). In preclinical models, Gouveia et al.…”

mentioning

confidence: 99%