volume 66, issue 7, P4228-4232 1992
DOI: 10.1128/jvi.66.7.4228-4232.1992
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A Marcuzzi, J Weinberger, O K Weinberger

Abstract: In this report, we describe a mechanism by which human immunodeficiency virus type 1 (HIV-1)-infected cells can influence neighboring HIV-1-infected T lymphocytes and uninfected T cells as well. We have examined the interaction of T-cell and macrophage cell lines that are transfected with HIV-1 DNA by using cocultured lymphocytes. The HIV-1 constructs we used lack a functional pol gene and therefore do not produce infectious virus. Cocultivation results in the transcellular activation of the HIV long terminal …

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