volume 66, issue 7, P4536-4539 1992
DOI: 10.1128/jvi.66.7.4536-4539.1992
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A Marcuzzi, I Lowy, O K Weinberger

Abstract: Cells expressing human immunodeficiency virus type 1 (HIV-1) tat can transactivate the HIV-1 long terminal repeat (LTR) in cocultured T lymphocytes. In this report, we describe the molecular requirements for transcellular activation of the LTR in Jurkat cells. An analysis with deletion mutants and blocking antibodies demonstrated a requirement for env expression in addition to tat expression for transcellular activation to occur. The results suggest that the transient association of CD4 and gpl20 in cocultured…

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