Transcatheter Aortic Valve Replacement: Does Kidney Function Affect Outcome?

Goebel, Nora; Baumbach, Hardy; Ahad, Samir; Voehringer, Matthias; Hill, Stephan; Albert, Marc; Franke, Ulrich

doi:10.1016/j.athoracsur.2013.04.035

Cited by 44 publications

(42 citation statements)

References 26 publications

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“…Other series however have not found an association between baseline renal function or the presence of CKD and AKI development after TAVI [29,41,45,46]. Post-operative red blood cell (RBC) transfusion has been strongly implicated in the literature as an independent predictor of AKI following TAVI [39,41,[46][47][48][49][50] but did not reach statistical significance in our multivariate model. Only six (5.3%) patients required post-operative RBC transfusion overall and although a greater proportion belonged to the group who did develop AKI compared to those who did not (12.5% vs. 3.3%, p = 0.107, Supplementary Table 4) this was not a statistically significant difference and was therefore likely underpowered in our model.…”

Section: Acute Kidney Injury Following Tavicontrasting

confidence: 44%

“…Goebel et al [39] compared 'CKD' and 'non-CKD' groups undergoing TAVI and reported their experience of 270 patients receiving transapical Edwards Sapien, Sapien XT or Jena Valves with approximately half defined as having pre-existing CKD. The AKI rate was 15.2% (20.2% in the CKD group, 12.8% in the 'normal' group) and 30-day mortality was 7.8% with no difference between CKD groups.…”

Section: Effect Of Pre-existing Ckd Following Tavimentioning

confidence: 99%

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92 Transcatheter Aortic Valve Implantation in Patients with Pre-existing Chronic Kidney Disease

Rahman

Sharma

Brecker

2015

Heart

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Background:We investigated the effect of chronic kidney disease (CKD) on morbidity and mortality following transcatheter aortic valve implantation (TAVI) including patients on haemodialysis, often excluded from randomised trials. Conclusion: TAVI is a safe, acceptable treatment for patients with pre-existing CKD, however caution must be exercised, particularly in patients with pre-existing diabetes mellitus and elevated pre-operative serum creatinine levels as this confers a greater risk of AKI development, which is associated with increased shortterm post-operative mortality.

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Section: Acute Kidney Injury Following Tavicontrasting

confidence: 44%

Section: Effect Of Pre-existing Ckd Following Tavimentioning

confidence: 99%

92 Transcatheter Aortic Valve Implantation in Patients with Pre-existing Chronic Kidney Disease

Rahman

Sharma

Brecker

2015

Heart

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“…A preclosure, which helped to reduce bleeding after balloon valvuloplasty in the Blockade of the glycoprotein IIb/IIIa Receptor to Avoid Vascular Occlusion (BRAVO) balloon valvuloplasty study, [15][16][17] was inserted in all cases of our cohort.…”

Section: Discussionmentioning

confidence: 99%

Bivalirudin vs Heparin in Patients Who Undergo Transcatheter Aortic Valve Implantation

Lange

Martin

Bongiovanni

et al. 2015

Canadian Journal of Cardiology

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“…[10][11][12][13][17][18][19][20][21] The characteristics of the included studies are reported in Table 1. There was no significant variability in the CKD definitions used across the studies.…”

Section: Resultsmentioning

confidence: 99%

Moderate and Severe Preoperative Chronic Kidney Disease Worsen Clinical Outcomes After Transcatheter Aortic Valve Implantation

Gargiulo

Capodanno

Sannino

et al. 2015

Circ: Cardiovascular Interventions

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T ranscatheter aortic valve implantation (TAVI) has emerged as an alternative to surgery therapy for severe aortic stenosis.1,2 The detrimental impact of baseline chronic kidney disease (CKD) on worsening the prognosis of patients undergoing surgical aortic valve replacement is well established. 3,4 Conversely, this remains a debated issue in patients undergoing TAVI.Mixed evidences are available regarding the relationship between baseline CKD and clinical outcomes in TAVI, and patients with CKD were typically under-represented in TAVI trials. On the other hand, CKD showed to be an independent predictor of mortality at 1-year after TAVI in some registries, [5][6][7][8] but not in others. 9 The degree of CKD, which exposes to the highest risk is also a matter of debate: recent data suggest that CKD stage 4 and 5, but not stage 3, are predictors of 30-day and late mortality after TAVI.10,11 Finally, cross-sectional studies failed to show a significant impact of CKD on mortality. 12,13 On this background, given the contrasting evidence and the latest literature in this field, there is a clinical and scientific rationale to investigate the impact of preoperative CKD on the clinical outcomes of patients undergoing TAVI. Methods Study SelectionThe study was designed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses requirements. MEDLINE, Cochrane, ISI Web of Science, and SCOPUS databases were searched Background-There is a conflicting evidence on safety and efficacy of transcatheter aortic valve implantation in patients with preoperative chronic kidney disease (CKD). Therefore, we conducted a meta-analysis on the impact of CKD on outcomes after transcatheter aortic valve implantation. Methods and Results-Nine

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Transcatheter Aortic Valve Replacement: Does Kidney Function Affect Outcome?

Cited by 44 publications

References 26 publications

92 Transcatheter Aortic Valve Implantation in Patients with Pre-existing Chronic Kidney Disease

92 Transcatheter Aortic Valve Implantation in Patients with Pre-existing Chronic Kidney Disease

Bivalirudin vs Heparin in Patients Who Undergo Transcatheter Aortic Valve Implantation

Moderate and Severe Preoperative Chronic Kidney Disease Worsen Clinical Outcomes After Transcatheter Aortic Valve Implantation

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