Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: A prospective randomised controlled trial of 29 patients

Total Knee Arthroplasty?; Post Operative Mean Blood Loss With Tranexamic Acid, Is Tranexamic Acid Effective in Reducing Blood Loss. A Randomized Controlled Trial in Tertiary Care Hospital, Pakistan

“…13 While on other side ,the Orpen et all study having similar results that it reduces the blood loss in early post operative day but there is significant decrease in total blood loss as well as the transfusion rate. 1 The main objection with the use of this drug is because of its complications like thromboembolism etc,but the Wrong et all found that there is no increase frequency of complications with this drug.They used tranexamic acid locally in the wound and found it as significant as orally or intravenous. 14 Alshryda S et all found that the evidence from trials does not support an increased risk of deepvein thrombosis or pulmonary embolism due to TXA administration.…”

“…1 The transfusion rate in it is about of 11-21% 2 Several factors affect the intra operative and post-operative blood loss like factors related to patient itself etc. Intraoperative tourniquet release for haemostasis causes more blood loss as compared to release after wound closure.…”

Universal tranexamic acid therapy to minimize transfusion for major joint arthroplasty: a retrospective analysis of protocol implementation

“…The rationale for AKI = acute kidney injury; DVT = deep vein thrombosis; Hb = hemoglobin concentration; MI = myocardial infarction; PE = pulmonary embolism; RBC = red blood cells; THA = total hip arthroplasty; TKA = total knee arthroplasty; TXA = tranexamic acid utilizing the TXA dose was established independently in 2012 prior to initiation of the protocol following an extensive review of available literature by the Pharmacy and Therapeutics Committee. [2][3][4][5][6][9][10][11][14][15][16][17] It was determined that, from the highly variable dosing reported, this 20 mgÁkg -1 dose provided a balance between reducing perioperative blood loss and RBC transfusion while limiting the incidence of potential adverse events. Nevertheless, this study did not incorporate a well-defined a priori standardized intraoperative fluid management strategy with strictly defined transfusion triggers, which limited the interpretation of our data.…”

“…Méthode Nous avons mis en oeuvre une politique de qualité des soins afin de procéder à l'administration universelle de TXA par voie intraveineuse à une dose de 20 mgÁkg -1 à tous les patients admissibles subissant une arthroplastie totale de la hanche ou du genou entre le 21 Administration of tranexamic acid (TXA) has been shown to reduce blood loss and allogeneic red blood cell (RBC) transfusion in cardiac and various noncardiac surgical procedures. 1 Many randomized controlled trials, [2][3][4][5][6] systematic reviews, and meta-analyses [7][8][9][10][11] have shown that systemic and topically administered TXA reduces allogeneic RBC transfusion in hip or knee arthroplasty surgery. Recent observational studies have also shown an association between TXA use and reduced RBC transfusion.…”

Total joint replacement and blood loss: what is the best equation?

“…Such operations are known to have a high volume of blood loss. Thus, blood loss for primary conventional TKA ranges from 726 to 1,768 ml [2][3][4][5][6]. Likewise, for primary conventional THA, blood loss ranges from 1,188 to 1,651 ml [7][8][9][10].…”