2018
DOI: 10.1038/s41598-018-31791-x View full text |Buy / Rent full text
|
|

Abstract: Abundant literature confirms that intravenous (IV) and intra-articular (IA) administration of tranexamic acid (TXA) reduces blood loss in total knee arthroplasty (TKA). Oral formulations of TXA exhibit profound cost-saving benefits. However, comparisons of the clinical efficacy among three different modalities of TXA administration have not been previously investigated in the setting of TKA with no closed suction drain and tourniquet. A total of 180 patients undergoing TKA were randomized to receive 2-g oral T… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
3
1
1
2
22
0

Year Published

2018
2018
2020
2020

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

2
22
0
Order By: Relevance
“…The results of this study suggested that no significant differences were found in blood-sparing management between oral and IV TXA. This finding is comparable to the findings of a recent meta-analysis that shown that oral TXA provided equivalent blood-sparing efficacy when compared with intravenous routes [ 23 ].…”
Section: Discussionsupporting
See 1 more Smart Citation
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 14 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 100,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…The results of this study suggested that no significant differences were found in blood-sparing management between oral and IV TXA. This finding is comparable to the findings of a recent meta-analysis that shown that oral TXA provided equivalent blood-sparing efficacy when compared with intravenous routes [ 23 ].…”
Section: Discussionsupporting
“…Based on the criteria described in the methods, 14 articles were further eliminated by reading the full articles, but some did not provide enough detail of outcomes of two approaches. Therefore, a final total of 9 studies [ 11 , 16 23 ] with included (Fig. 1 ).…”
Section: Resultsmentioning
“…The Hb drop and total blood loss were the primary outcomes in our meta-analysis. Many studies [ 23 , 25 , 27 31 ] demonstrated that oral TXA provides similar reductions in Hb drop and total blood loss in primary THA and TKA compared with IV TXA. The results of this study found no significant differences in Hb drop and total blood loss between oral and IV TXA.…”
Section: Discussionmentioning
“…We conclude that compared with IV administration, the use of oral TXA has the same effects as IV TXA on the transfusion rate following THA and TKA. [ 31 , 32 ]…”
Section: Discussionmentioning
“…Unlike other surgical procedures, there was no good way to control bleeding of the bone surface of the femur and tibia after osteotomy during TKA and this will cause trouble for non-tourniquet TKA. The use of tranexamic acid and control of the blood pressure during the operation are effective methods to reduce the bleeding of the surgical field [8][9][10]. The former studies showed that the use of tranexamic can not only reduce the total blood loss during the perioperative period but also reduce the intraoperative blood loss [11,12].…”
Section: Introductionmentioning