2021
DOI: 10.1186/s12959-021-00303-9
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Abstract: Objectives We review the evidence for tranexamic acid (TXA) for the treatment and prevention of bleeding caused by surgery, trauma and bleeding disorders. We highlight therapeutic areas where evidence is lacking and discuss safety issues, particularly the concern regarding thrombotic complications. Methods An electronic search was performed in PubMed and the Cochrane Library to identify clinical trials, safety reports and review articles. … Show more

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Cited by 33 publications
(25 citation statements)
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References 149 publications
(215 reference statements)
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“…Tranexamic acid (TXA)-IUPAC name: trans-4-aminomethyl cyclohexane carboxylic acid-is a synthetic lysine analog well known for its anti-fibrinolytic activity. TXA has been used for several years to treat heavy bleedings, e.g., during menstruation or surgery as well as in case of trauma and bleeding disorders [49]. In recent years, TXA became more and more popular as a depigmenting agent.…”
Section: Newly Emerging Depigmenting Agents 31 Txa In Different Formsmentioning
confidence: 99%
“…Tranexamic acid (TXA)-IUPAC name: trans-4-aminomethyl cyclohexane carboxylic acid-is a synthetic lysine analog well known for its anti-fibrinolytic activity. TXA has been used for several years to treat heavy bleedings, e.g., during menstruation or surgery as well as in case of trauma and bleeding disorders [49]. In recent years, TXA became more and more popular as a depigmenting agent.…”
Section: Newly Emerging Depigmenting Agents 31 Txa In Different Formsmentioning
confidence: 99%
“…It was first described in the 1960's 24,25 . TXA acts by inhibiting the interaction of fibrin with plasminogen, hindering fibrinolysis and preserving blood clots from degradatio 26 . TXA binds the 5 binding sites on plasminogen and in thus inhibits plasmin formation and displaces plasminogen from the fibrin surface.…”
Section: Mechanism Of Action Of Tranexamic Acid Mechanism Of Action O...mentioning
confidence: 99%
“…Tromboembolická příhoda byla v této analýze studií popsána u 2 % pacientů bez ohledu na expozici TXA. Excelentní review k problematice podání TXA přinesly článek Ockerman et al [34] a ilustrovaná publikace Relke et al [35].…”
Section: Zástava Oběhuunclassified