Traitement de la pelade par bolus oral mensuel de prednisone

Ourhroui, M. Ait; Hassam, B.; Khoudri, Ibtissam

doi:10.1016/j.annder.2010.06.002

Cited by 17 publications

(4 citation statements)

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“…In one study, a once-monthly oral pulse of 300 mg prednisone induced a complete response in 41% of patients. [ 11 ] A similar effect has been reported in a placebo-controlled trial of oral prednisolone 200 mg once weekly in the treatment of extensive AA. [ 12 ] The relapse rate was 25%, and side effects of the therapy were noted in 55% of patients.…”

Section: Discussionsupporting

confidence: 59%

Role of platelet-rich plasma in chronic alopecia areata: Our centre experience

Singh¹

2015

Indian J Plast Surg

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Aim:The aim of the study was to evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of chronic alopecia areata (AA).Material and Methods:This is a prospective study that was conducted at Kamal Hospital, Kaushambi in which 20 patients who attended the outpatient department were enrolled for the study. All the patients had h/o patches and taken various line of treatments for a duration of 2 years. All the patients were biopsy-proven positive for AA disease. There was no randomisation done since all of them were healthy young adults. The patients’age ranged from 25 to 35 years, and none of them had any co-morbidities.Results:Of 20 patients, only one patient had a relapse. None of the patients had any side effects, and all of them tolerated the procedure well.Conclusion:We wish to conclude that PRP has a definite role in treating AA infections. However, still more long-term follow-up, studies are required for further validation of results and labelling it as a 100% cure for people suffering from AA with recurrences which are so common.

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Section: Discussionsupporting

confidence: 59%

Role of platelet-rich plasma in chronic alopecia areata: Our centre experience

Singh¹

2015

Indian J Plast Surg

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“…Various forms of corticosteroids have been used in different regimens. In one study, a once-monthly oral pulse of 300 mg prednisone induced a complete response in 41% of patients 49. A similar effect has been reported in a placebo-controlled trial of oral prednisolone 200 mg once weekly in the treatment of extensive alopecia areata 50.…”

Section: Third-line Therapiessupporting

confidence: 53%

Alopecia areata: a new treatment plan

Alsantali

2011

CCID

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Many therapeutic modalities have been used to treat alopecia areata, with variable efficacy and safety profiles. Unfortunately, none of these agents is curative or preventive. Also, many of these therapeutic agents have not been subjected to randomized, controlled trials, and, except for topical immunotherapy, there are few published studies on long-term outcomes. The treatment plan is designed according to the patient’s age and extent of disease. In this paper, the therapeutic agents are organized according to their efficacy and safety profiles into first-line, second-line, and third-line options.

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“…Forty two studies looked for all possible symptomatic ADRs [ 13 – 28 , 30 – 41 , 44 , 47 , 48 , 52 , 53 , 55 – 62 , 64 ]. Fourteen of them also evaluated HPA axis suppression specifically [ 14 – 16 , 22 , 32 , 36 , 41 , 51 – 53 , 55 – 58 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of the Toxicity of Long-Course Oral Corticosteroids in Children

2017

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BackgroundLong courses of oral corticosteroids are commonly used in children in the management of chronic conditions. Various adverse drug reactions (ADRs) are known to occur with their use. This systematic review aimed to identify the most common and serious ADRs and to determine their relative risk levels.MethodsA literature search of Embase, Medline, International Pharmaceutical Abstracts, CINAHL, Cochrane Library and PubMed was performed with no language restrictions in order to identify studies where oral corticosteroids were administered to patients aged 28 days to 18 years of age for at least 15 days of treatment. Each database was searched from their earliest dates to January 2016. All studies providing clear information on ADRs were included.ResultsOne hundred and one studies including 33 prospective cohort studies; 21 randomised controlled trials; 21 case series and 26 case reports met the inclusion criteria. These involved 6817 children and reported 4321 ADRs. The three ADRs experienced by the highest number of patients were weight gain, growth retardation and Cushingoid features with respective incidence rates of 21.1%, 18.1% and 19.4% of patients assessed for these ADRs. 21.5% of patients measured showed decreased bone density and 0.8% of patients showed osteoporosis. Biochemical HPA axis suppression was detected in 269 of 487 patients where it was measured. Infection was the most serious ADR, with twenty one deaths. Varicella zoster was the most frequent infection (9 deaths).ConclusionsWeight gain, growth retardation and Cushingoid features were the most frequent ADRs seen when long-course oral corticosteroids were given to children. Increased susceptibility to infection was the most serious ADR.

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Traitement de la pelade par bolus oral mensuel de prednisone

Cited by 17 publications

References 12 publications

Role of platelet-rich plasma in chronic alopecia areata: Our centre experience

Role of platelet-rich plasma in chronic alopecia areata: Our centre experience

Alopecia areata: a new treatment plan

Systematic Review of the Toxicity of Long-Course Oral Corticosteroids in Children

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