Traitement de la maladie de Darier par 5-fluorouracile topique : quelle efficacité, quels risques ?

Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options

“…Moreover, antiseptic solutions (such as triclosan and astringents) and topical antibiotics (including fusidic acid and mupirocin) are effective in reducing secondary bacterial colonization and malodor [ 13 ]. Previous studies have shown that 5-fluorouracil, calcineurin inhibitors, and synthetic vitamin D 3 analog are considered as treatment alternatives [ 18 , 19 , 20 , 21 , 22 ].…”

Combination of alitretinoin and topical 5-fluorouracil in Darier disease

“…The use of topical 5-FU alone or combined with corticosteroids (n = 1) or acitretin (n = 2) was previously published in 10 observations of DD with significant improvement reported in 8 of 10 patients but never combined with alitretinoin ( Table II ). 7 , 8 , 9 , 10 , 11 5-FU's mode of action is unclear, but an impact on the intracytoplasmic calcium has been hypothesized to improve dyskeratosis.…”

“… 7 , 8 , 9 , 10 , 11 5-FU's mode of action is unclear, but an impact on the intracytoplasmic calcium has been hypothesized to improve dyskeratosis.…”

Hypopigmented Segmental Darier Disease

“…A few reports documented promising results with topical 5-fluorouracil cream; however, a recent case series suggests that this treatment may lead to tachyphylaxis. 21–23…”

“…A few reports documented promising results with topical 5-fluorouracil cream; however, a recent case series suggests that this treatment may lead to tachyphylaxis. [21][22][23] Conclusion Darier disease is a genodermatosis caused by a mutation in the ATP2A2 gene. Several variants have been reported in the literature, notably segmental and guttate hypopigmented forms.…”