Traditional Chinese Medicine in Treating Influenza: From Basic Science to Clinical Applications

Xiong, Ye; Li, Na Xiao; Duan, Naifang; Liu, Bin; Zhu, Haiyan; Zhang, Chi; Li, Li; Lü, Cheng; Huang, Luqi

doi:10.3389/fphar.2020.575803

Cited by 31 publications

(17 citation statements)

References 75 publications

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“…10 However, increased use of alternative medicine was reported earlier during the outbreaks like influenza and severe acute respiratory syndrome (SARS). 11,12 The first confirmed COVID-19 case in India was reported from Kerala state on 31 January 2020. 13 Kerala is the most literate state in India and the human resource for health in the state is one of the best reported from the country.…”

Section: India Has a Long Tradition Of Cam Use Asmentioning

confidence: 98%

Complementary and alternative medicine use in the prevention of COVID-19 pandemic: a cross-sectional survey in Kerala, India

Mini

Grace

Lordson

2021

Int J Community Med Public Health

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Background: Globally, there is evidence of increased Complementary and alternative medicine (CAM) use during epidemics, and pandemics. Recent studies have shown that there is an increased use of CAM during the coronavirus disease (COVID-19) pandemic. The aim of the study was to investigate the pattern of CAM practice in the prevention of COVID-19 pandemic among adults in Kerala state, India.Methods: This was a cross-sectional descriptive study conducted in the first week of June 2021 among adults residing in Kerala state. The study used a pre-tested google form to collect the data. A total of 548 individuals aged 18-84 years answered an online questionnaire for the present study.Results: A higher proportion (52.4%) of participants were aged <30 years, 30.8% were males, 55.3% rural residents, 26.6% health care professionals, and 51.1% had a regular income. CAM use prevalence was 59.3% (95% CI: 55.1 to 63.3). Social media (46.9%) was the most frequently reported source of CAM. The age-adjusted analysis results showed that CAM use was higher among health professionals (OR: 2.15, 95% CI: 1.41-3.27), those who did not believe that vaccine could prevent coronavirus (OR: 1.91 CI: 1.08-3.39), and those who were having no regular income (OR: 1.56, CI: 1.04-2.34), compared to their counterparts.Conclusions: Close to 60% of CAM use in this population is a public health concern since the efficacy of CAM use for the prevention or treatment of COVID-19 is not known. The CAM users will be under a sense of false protection, which is likely to negate vaccination and seeking proper treatment for COVID -19 in Kerala.

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Section: India Has a Long Tradition Of Cam Use Asmentioning

confidence: 98%

Complementary and alternative medicine use in the prevention of COVID-19 pandemic: a cross-sectional survey in Kerala, India

Mini

Grace

Lordson

2021

Int J Community Med Public Health

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“…As a mixture of various plant extracts, Chinese herbal formulae, such as Gegen Qinlian soup, Lianhua-qingwen capsule, and Yinqiao powder, have been shown to have potent antiviral activity in the clinic [ 104 , 105 , 106 ] ( Table 3 ).…”

Section: Development and Effects Of Influenza Antiviral Drugsmentioning

confidence: 99%

Development and Effects of Influenza Antiviral Drugs

et al. 2021

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Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Currently, there are two classes of antiviral drugs available that are chemosynthetic and approved against influenza A virus for prophylactic and therapeutic treatment, but the appearance of drug-resistant virus strains is a serious issue that strikes at the core of influenza control. There is therefore an urgent need to develop new antiviral drugs. Many reports have shown that the development of novel bioactive plant extracts and microbial extracts has significant advantages in influenza treatment. This paper comprehensively reviews the development and effects of chemosynthetic drugs, plant extracts, and microbial extracts with influenza antiviral activity, hoping to provide some references for novel antiviral drug design and promising alternative candidates for further anti-influenza drug development.

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“…Viral yield reduction assay was performed as previously described 22 . Brie y, MDCK cells growing in 24well plates were infected with A/H1N1/PR8, oseltamivirresistant in uenza A/H1N1/pdm(09), A/H3N2/Brisbane, B-Yamagata-like, and B-Victoria-like strains at MOI of 0.01 with or without various concentrations of ALLO, respectively.…”

Section: Viral Titer Reduction Assaymentioning

confidence: 99%

“…And a series of traditional Chinese medicines or extracted active ingredients, not only in vitro antiviral experiments, but also in the clinical treatment of in uenza, all displayed vital value and broad development prospects [20][21][22]. In this study, we performed a high-throughput antiviral screening of 891 natural products using a recombinant replication-competent reporter in uenza virus, and Allopregnanolone (ALLO) was identi ed possessing the anti-in uenza e cacy with broad spectrum, acting inhibition on the viral replication stage.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Allopregnanolone Against Influenza Virus With Broad Spectrum in Vitro

Wang

Cao

2021

Preprint

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Background: Influenza virus infection with seasonal or occasional but devastating morbidity and mortality, is a severe threat to public health. The frequent emergence of resistant viral strains limited application of current antivirals and posing an urgent need for novel antiviral therapies. Natural products offered a broad prospect in the screening and development of new influenza inhibitors.Methods: In this research, a high-throughput antiviral screening for 891 natural products was performed based on a recombinant reporter influenza A virus. According to the cytotoxicity assay and dose-response relationship, alloprogesterone (ALLO), as the positive hit was selected, and verified by viral titer reduction assay and immunofluorescence using a wild-type virus. Followingly, we explored its antiviral potency of counteracting with IAV and IBV, and preliminary investigated the mechanism of ALLO through time-of-addition assay and mini-replicon system.Results: Under the criteria of 80% inhibition and 70% cell viability, ALLO was screened out and confirmed antiviral activity in varied cells. The inhibitory effect of ALLO against influenza virus with a dose-dependent manner and significantly reduced viral yield of five different influenza viruses in the presence of 40 µM ALLO, including oseltamivir-resistant virus. Moreover, ALLO exhibited no influence on IAV entry or release during the viral replication cycle, but obviously interfered with the genome replication regarding post-infection 2 hrs to 6 hrs, which is consistent with the evidence of decreased polymerase activity.Conclusions: In summary, we firstly identified a new pharmacological activity of ALLO, as a broad spectrum inhibitor for treatment influenza infections, targeting viral replication stage and possessing great value of further development.

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Traditional Chinese Medicine in Treating Influenza: From Basic Science to Clinical Applications

Cited by 31 publications

References 75 publications

Complementary and alternative medicine use in the prevention of COVID-19 pandemic: a cross-sectional survey in Kerala, India

Complementary and alternative medicine use in the prevention of COVID-19 pandemic: a cross-sectional survey in Kerala, India

Development and Effects of Influenza Antiviral Drugs

Discovery of Allopregnanolone Against Influenza Virus With Broad Spectrum in Vitro

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