Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis

Li, Yuxi; Liu, Xiaobo; Guo, Liuxue; Li, Juan; Zhong, Dongling; Zhang, Yonggang; Clarke, Mike; Jin, Rongjiang

doi:10.1186/s13643-020-01343-4

Cited by 110 publications

(59 citation statements)

References 23 publications

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“…Many researchers have reported the beneficial effect of natural compounds in treating HIV infections (Reiter et al, 2015;Salehiet al, 2018) Hydroxychloroquine was also observed to significantly decrease SARS-CoV-2 infection (Gautretet al, 2020). Li et al, 2020 reported that traditional Chinese herbal medicine treatments alone or in combination with western medicine can be successful in preventing and treating COVIS-19 (Li et al, 2020). Based on these reports it is clear that it is necessary to repurpose natural compounds especially phytochemicals as prophylaxis to manage patients with COVID-19.…”

Section: Resultsmentioning

confidence: 99%

Nature to Nurture- Identifying Phytochemicals from Indian Medicinal Plants as Prophylactic Medicine by Rational Screening to Be Potent Against Multiple Drug Targets of SARS-CoV-2

Parida¹,

Paul²,

Chakravorty

2020

Preprint

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The COVID-19 pandemic resulted in millions of people being quarantined, impacting the world economy and health sector. There is no existing proven treatment for this disease. It may takea long time until a good candidate vaccine or a potent drug is made available in the market. Therefore, there is a need to search for alternative therapy. In the context, this work explored natural compounds from Indian medicinal plants to develop a prophylactic treatment regimen that will be instrumentalin controlling the spread of the deadly virus. In this work 1916 phytochemicals from 55 Indian medicinal plants, reported to possess anti-viral properties, were subjected to virtual screening on 8 structural and non-structural SARS-CoV-2 protein targets. Docking interactions, ADME and toxicity profiles of the 66 screened phytochemicals were correlated with 21 repurposed drugs that have been most cited in literature to be effective against SARS-CoV-2. Steroidal lactones from Withaniasomnifera and triterpenoids from Azadirachtaindica- with docking score ranging from -13 kcal/mol upto -6 kcal/mol were identified to occupy the top scoring virtually screened phytochemicals against the various targets of SARS-CoV-2. Importantly this work proposes that a concoction of these phytochemicals can act as prophylactic anti-viral medicine to control the spread of SARS-CoV-2 and also enhance natural immunity as the first line of defence towards such a deadly virus.

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Section: Resultsmentioning

confidence: 99%

Nature to Nurture- Identifying Phytochemicals from Indian Medicinal Plants as Prophylactic Medicine by Rational Screening to Be Potent Against Multiple Drug Targets of SARS-CoV-2

Parida¹,

Paul²,

Chakravorty

2020

Preprint

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“…Therefore, it is not surprising that thousands of TCM practitioners across China have been working along with regular medical doctors to control the COVID-19 disease. The clinical data generated from tens of thousands of confirmed cases are being subjected to meta-analyses to ascertain their actual effectiveness (Li et al, 2020). In the meantime, the Diagnosis and Treatment Protocol of COVID-19 by the National Health Commission has already advised to integrate TCM in the treatment of COVID-19 patients to effectively relieve symptoms such as fever, cough, sore throat, myalgia, and fatigue, shorten the course of the disease, reduce the probability of life-threatening complications (Xu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Based on clinical results, the General Office of the National Health, and the Office of the State Administration of Traditional Chinese Medicine encouraged the integration of herbal TCM and Western medicine in the treatment of respiratory complications in Coronavirus infections with different prescriptions recommended in different stages of disease (Leung, 2007). After SARS-CoV-2 disease outbreak, a number of clinical trials with Traditional Herbal Medicines (THM) have been added to the body of evidence with some favorable findings when compared to standard antiviral therapy (Langeder et al, 2020;Li et al, 2020;Luo et al, 2020;Rastogi et al, 2020).…”

Section: Plectranthus Amboinicus Lour -Lamiaceae (Leaves)mentioning

confidence: 99%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method: The plant selection was primarily based on species listed by the WHO and EMA, but some other herbal remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical data on their efficacy and safety were collected from authoritative sources. The target population were adults with early and mild flu symptoms without underlying conditions. These were evaluated according to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The benefits/risks balance of the treatments was classified as positive, promising, negative, and unknown. Results: A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases (Allium sativum, Andrographis paniculata, Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulus essential oil, Justicia pectoralis, Magnolia officinalis, Mikania glomerata, Pelargonium sidoides, Pimpinella anisum, Salix sp, Zingiber officinale), and unknown for the rest. On the same grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. Conclusions: Our work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical

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“…Makino], Forsythia Fruit [Forsythia suspensa (Thunb.) Vahl], and Bitter Apricot Seed (Prunus armeniaca L.) are the most frequently prescribed herbs (Li et al, 2020). Their meta-analysis showed that herbal medicines are effective in halting the disease progression from mild to critical, decreasing hospitalization rate, shortening time of hospital stay, as well as alleviating COVID-19 associated symptoms like fever, cough, fatigue, and inflammation (Li et al, 2020).…”

Section: Herbal Medicines Alleviating Acute Respiratory Infectionmentioning

confidence: 99%

Current Prevention of COVID-19: Natural Products and Herbal Medicine

et al. 2020

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Starting from December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and unprecedented health crisis across the globe. While the development of cure is at full speed, less attention and fewer effort have been spent on the prevention of this rapidly spreading respiratory infectious disease. Although so far, several vaccine candidates have advanced into clinical trials, limited data have been released regarding the vaccine efficacy and safety in human, not mention the long-term effectiveness of those vaccines remain as open question yet. Natural products and herbal medicines have been historically used for acute respiratory infection and generally show acceptable toxicity. The favorable stability for oral formulation and ease of scaling up manufacture make it ideal candidate for prophylactic. Hereby, we summarized the most recent advance in SARS-CoV-2 prevention including vaccine development as well as experimental prophylactics. Mainly, we reviewed the natural products showing inhibitory effect on human coronavirus, and discussed the herbal medicines lately used for COVID-19, especially focused on the herbal products already approved by regulatory agency with identifiable patent number. We demonstrated that to fill in the response gap between appropriate treatment and commercially available vaccine, repurposing natural products and herbal medicines as prophylactic will be a vigorous approach to stop or at least slow down SARS-CoV-2 transmission. In the interest of public health, this will lend health officials better control on the current pandemic.

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Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis

Cited by 110 publications

References 23 publications

Nature to Nurture- Identifying Phytochemicals from Indian Medicinal Plants as Prophylactic Medicine by Rational Screening to Be Potent Against Multiple Drug Targets of SARS-CoV-2

Nature to Nurture- Identifying Phytochemicals from Indian Medicinal Plants as Prophylactic Medicine by Rational Screening to Be Potent Against Multiple Drug Targets of SARS-CoV-2

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

Current Prevention of COVID-19: Natural Products and Herbal Medicine

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