Traditional and Economic Valuation of Edible Plants Used for the Treatment of Diabetes

Mir, Showkat R.; Ahamad, Javed; Varma, Vandana; Usmani, Zakiya; Mujeeb, Mohd; Kaskoos, Raad A; Amin, Saima

doi:10.1007/978-981-16-4880-9_3

Cited by 2 publications

(2 citation statements)

References 66 publications

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“…Recently, curcumin use has been applied as a potential therapeutic strategy in curing a range of complications in diabetic patients and it is quite cost-effective as well as reliable in medical therapy, which has increased scientific interest towards this component. 53,54…”

Section: Molecular Mechanisms Of the Anti-diabetic Effects Of Curcumi...mentioning

confidence: 99%

Effects of curcumin, a bioactive component of turmeric, on type 2 diabetes mellitus and its complications: an updated review

2022

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Section: Molecular Mechanisms Of the Anti-diabetic Effects Of Curcumi...mentioning

confidence: 99%

Effects of curcumin, a bioactive component of turmeric, on type 2 diabetes mellitus and its complications: an updated review

2022

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“…Diabetes mellitus (DM) is a multifactorial metabolic disorder that is clinically characterized by postprandial hyperglycemia and associated with cardiovascular events, kidney failure, and retinopathy along with neuropathy (Ahmed et al, 2022; Alizadeh et al, 2022; Kuka et al, 2022; Nørgaard et al, 2022). Despite profound advances in this area, the complete treatment of diabetes is still under progress (Mir et al, 2022). DM is categorized into several types; the most common types are type I and type II.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, biological evaluation, and molecular docking study of chromen‐linked hydrazine carbothioamides as potent α‐glucosidase inhibitors

Basri

Ullah

Halim

et al. 2023

Drug Development Research

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Inhibiting α‐glucosidase is a reliable method for reducing blood sugar levels in diabetic individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed and synthesized by condensation of chromone‐3‐carbaldehyde with a variety of substituted thiosemicarbazides. The structures of these new analogues were elucidated through various advanced spectroscopic techniques (1H NMR, 13C NMR, and ESI‐MS). The resulted compounds were screened for α‐glucosidase inhibitory potential and all the compounds (3a–r) exhibited potent inhibition of α‐glucosidase with IC50 values ranging 0.29–53.70 µM. Among them compounds 3c, 3f, 3h, and 3r displayed the highest α‐glucosidase inhibitor capability with IC50 values of 1.50, 1.28, 1.08, and 0.29 µM, respectively. Structure–activity relationship showed that different substituted groups are responsible for the variation in the α‐glucosidase inhibition. The kinetics studies of the most active inhibitor (3r) were performed, to investigate the mode of inhibition and dissociation constants (Ki), that indicated a competitive inhibitor with Ki value of 1.47 ± 0.31 µM. Furthermore, molecular docking studies was performed to reveal the possible interactions, such as H‐bonding, or π–π stacking, with the key residues of α‐glucosidase. Docking analysis revealed the importance of hydrazine carbothioamide moiety of compounds in the attachment of ligands with the crucial residues of α‐glucosidase. The estimated pharmacokinetic, physicochemical, and drug likeness properties of compounds 3a–r reflects that these molecules have acceptable range of these properties.

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Traditional and Economic Valuation of Edible Plants Used for the Treatment of Diabetes

Cited by 2 publications

References 66 publications

Effects of curcumin, a bioactive component of turmeric, on type 2 diabetes mellitus and its complications: an updated review

Effects of curcumin, a bioactive component of turmeric, on type 2 diabetes mellitus and its complications: an updated review

Synthesis, biological evaluation, and molecular docking study of chromen‐linked hydrazine carbothioamides as potent α‐glucosidase inhibitors

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