Tract-based analysis of white matter integrity in psychotic and nonpsychotic bipolar disorder

Ji, A.B.; Godwin, Douglass; Rutlin, Jerrel; Kandala, Sridhar; Shimony, Joshua S.; Mamah, Daniel

doi:10.1016/j.jad.2016.11.038

Cited by 22 publications

(22 citation statements)

References 68 publications

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“…Previous neuroimaging studies of youth and adults with BD provide similar findings regarding WMT and activity abnormalities during emotion processing. Studies reported that individuals with, and at risk for, BD have abnormally low ACC activity (Blumberg et al, 2005;Chan et al, 2016;Dolcos et al, 2011;Phillips et al, 2003;Phillips et al, 2008) and fiber collinearity in the forceps minor (Benedetti et al, 2011b;Chaddock et al, 2009;Emsell et al, 2013;Haller et al, 2011;Jenkins et al, 2016;Ji et al, 2017;Nortje et al, 2013;Versace et al, 2014;Versace et al, 2010b;Wang et al, 2008b). Our findings add to this literature by showing that, in OBP, lower fiber collinearity in the forceps minor was associated with lower activity to happy faces in the rACC.…”

Section: Discussionsupporting

confidence: 77%

White matter – emotion processing activity relationships in youth offspring of bipolar parents

Acuff

Versace

Bertocci

et al. 2019

Journal of Affective Disorders

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Section: Discussionsupporting

confidence: 77%

White matter – emotion processing activity relationships in youth offspring of bipolar parents

Acuff

Versace

Bertocci

et al. 2019

Journal of Affective Disorders

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“…At the same time, BD patients have greater MD in the cingulum, corpus callosum, corona radiata, internal capsule, tapetum and occipital white matter including posterior thalamic radiation, inferior longitudinal fasciculus/inferior fronto-occipital fasciculus (Lu et al, 2011 ). Numerous follow up studies confirmed these data (Lu et al, 2012 ; Emsell et al, 2013 ; Sprooten et al, 2016 ; Ji et al, 2017 ). Similar, but more subtle white matter microstructural changes were detected in unaffected siblings as well (Sprooten et al, 2013 , 2016 ).…”

Section: Cellular Evidences For Glial Pathologymentioning

confidence: 78%

“…DTI studies report on reduced fractional anisotropy in the cingulum, internal capsule, posterior corpus callosum, tapetum, and occipital white matter (Lu et al, 2011 , 2012 ; Emsell et al, 2013 ; Sprooten et al, 2016 ; Ji et al, 2017 )…”

Section: Cellular Evidences For Glial Pathologymentioning

confidence: 99%

Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders

Czéh

Nagy

2018

Front. Mol. Neurosci.

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Depressive disorders are complex, multifactorial mental disorders with unknown neurobiology. Numerous theories aim to explain the pathophysiology. According to the “gliocentric theory”, glial abnormalities are responsible for the development of the disease. The aim of this review article is to summarize the rapidly growing number of cellular and molecular evidences indicating disturbed glial functioning in depressive disorders. We focus here exclusively on the clinical studies and present the in vivo neuroimaging findings together with the postmortem molecular and histopathological data. Postmortem studies demonstrate glial cell loss while the in vivo imaging data reveal disturbed glial functioning and altered white matter microstructure. Molecular studies report on altered gene expression of glial specific genes. In sum, the clinical findings provide ample evidences on glial pathology and demonstrate that all major glial cell types are affected. However, we still lack convincing theories explaining how the glial abnormalities develop and how exactly contribute to the emotional and cognitive disturbances. Abnormal astrocytic functioning may lead to disturbed metabolism affecting ion homeostasis and glutamate clearance, which in turn, affect synaptic communication. Abnormal oligodendrocyte functioning may disrupt the connectivity of neuronal networks, while microglial activation indicates neuroinflammatory processes. These cellular changes may relate to each other or they may indicate different endophenotypes. A theory has been put forward that the stress-induced inflammation—mediated by microglial activation—triggers a cascade of events leading to damaged astrocytes and oligodendroglia and consequently to their dysfunctions. The clinical data support the “gliocentric” theory, but future research should clarify whether these glial changes are truly the cause or simply the consequences of this devastating disorder.

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“…ROI-based analysis requires a priori delineation of white matter regions, which can be challenging for smaller regions (Mukherjee et al, 2008), while voxel-based methods can be complicated by inaccuracies with registration algorithms using tensor datasets (Mukherjee et al, 2008) and have been shown to be very sensitive to differences in processing parameters (Jones et al, 2005). Recently, TRACULA (TRActs Constrained by UnderLying Anatomy), an automated probabilistic tractography toolbox within Freesurfer (Yendiki et al, 2011), was used to segment 18 major white matter tracts in BP and showed decreased FA in multiple tracts, including the superior longitudinal fasciculus, cingulum, and corticospinal tracts (Ji et al, 2017; Sprooten et al, 2016). To our knowledge, TRACULA has not been previously used to investigate white matter tract abnormality in SZ.…”

Section: Introductionmentioning

confidence: 99%

White matter integrity in schizophrenia and bipolar disorder: Tract- and voxel-based analyses of diffusion data from the Connectom scanner

Mamah

Rutlin

et al. 2019

NeuroImage: Clinical

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BackgroundDiffusion imaging abnormalities have been associated with schizophrenia (SZ) and bipolar disorder (BD), indicating impaired structural connectivity. Newer methods permit the automated reconstruction of major white matter tracts from diffusion-weighted MR images in each individual's native space. Using high-definition diffusion data from SZ and BP subjects, we investigated brain white matter integrity using both an automated tract-based and voxel-based methods.MethodsUsing a protocol matched to the NIH (Young-Adult) Human Connectome Project (and collected on the same customized ‘Connectom’ scanner), diffusion scans were acquired from 87 total participants (aged 18–30), grouped as SZ (n = 24), BD (n = 33) and healthy controls (n = 30). Fractional anisotropy (FA) of eighteen white matter tracks were analyzed using the TRACULA software. Voxel-wise statistical analyses of diffusion data was carried out using the tract-based spatial statistics (TBSS) software. TRACULA group effects and clinical correlations were investigated using analyses of variance and multiple regression.ResultsTRACULA analysis identified a trend towards lower tract FA in SZ patients, most significantly in the left anterior thalamic radiation (ATR; p = .04). TBSS results showed significantly lower FA voxels bilaterally within the cerebellum and unilaterally within the left ATR, posterior thalamic radiation, corticospinal tract, and superior longitudinal fasciculus in SZ patients compared to controls (FDR corrected p < .05). FA in BD patients did not significantly differ from controls using either TRACULA or TBSS. Multiple regression showed FA of the ATR as predicting chronic mania (p = .0005) and the cingulum-angular bundle as predicting recent mania (p = .02) in patients. TBSS showed chronic mania correlating with FA voxels within the left ATR and corpus callosum.ConclusionsWhite matter abnormality in SZ varies in severity across different white matter tract regions. Our results indicate that voxel-based analysis of diffusion data is more sensitive than tract-based analysis in identifying such abnormalities. Absence of white matter abnormality in BD may be related to medication effects and age.

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Tract-based analysis of white matter integrity in psychotic and nonpsychotic bipolar disorder

Cited by 22 publications

References 68 publications

White matter – emotion processing activity relationships in youth offspring of bipolar parents

White matter – emotion processing activity relationships in youth offspring of bipolar parents

Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders

White matter integrity in schizophrenia and bipolar disorder: Tract- and voxel-based analyses of diffusion data from the Connectom scanner

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