2017
DOI: 10.1056/nejmoa1616288
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Abstract: Intratumor heterogeneity mediated through chromosome instability was associated with an increased risk of recurrence or death, a finding that supports the potential value of chromosome instability as a prognostic predictor. (Funded by Cancer Research UK and others; TRACERx ClinicalTrials.gov number, NCT01888601 .).

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Cited by 1,795 publications
(1,943 citation statements)
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References 29 publications
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“…We attempted cell culture from 12 patients (median age = 75 years, range = 58–90 years), whose surgically resected primary lung adenocarcinoma (LUAD) tumors (stage II [ n  = 9] or III [ n  = 3]) are being analyzed in the on‐going Tracking Cancer Evolution through Therapy (TRACERx) clinical study,14, 15 using a published protocol 17. We obtained primary epithelial cell cultures that could be passaged from 10 (83.3%) of these.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…We attempted cell culture from 12 patients (median age = 75 years, range = 58–90 years), whose surgically resected primary lung adenocarcinoma (LUAD) tumors (stage II [ n  = 9] or III [ n  = 3]) are being analyzed in the on‐going Tracking Cancer Evolution through Therapy (TRACERx) clinical study,14, 15 using a published protocol 17. We obtained primary epithelial cell cultures that could be passaged from 10 (83.3%) of these.…”
Section: Resultsmentioning
confidence: 99%
“…Here, we present cell culture outcomes for 12 lung adenocarcinoma patients enrolled in the on‐going Tracking Cancer Evolution through Therapy (TRACERx) clinical study 14, 15. We found that contaminating normal epithelial cells were the predominant cell type present in early passage cultures, although tumor cells were cultured in one case.…”
Section: Introductionmentioning
confidence: 99%
“…To prospectively investigate ITH in relation to clinical outcome and to determine the clonal nature of driver events and evolutionary processes in early‐stage NSCLC, Jamal‐Hanjani et al22 sequenced 327 tumor regions and 100 matched germline samples derived from whole blood. These data may have important implications for understanding tumor biology and therapeutic control in NSCLC.…”
Section: Further Analysis Of Ith For Clinical Applicationsmentioning
confidence: 99%
“…1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35 This multiregional analysis (MRA) sequencing approach enabled us not only to observe spatial heterogeneity, but also to calculate temporal alterations and eventually disclose the evolution of tumors. There are two types of somatic aberration in a tumor: ubiquitous aberrations (founder mutations, trunk mutations, or clonal mutations) and scattered aberrations (progressor mutations, branch/leaf mutations, or subclonal mutations).…”
Section: Introductionmentioning
confidence: 99%
“…Swanton and colleagues have reported preliminary results of the whole-exome sequencing of 100 early-stage NSCLC in order to correlate the heterogeneity towards the study of clonal and subclonal events to meaningful clinical outcome named recurrence-free survival (5).…”
mentioning
confidence: 99%