Tracking Plasmacytoid Dendritic Cell Response to Physical Contact with Infected Cells

Ribeiro, Margarida Sa; Joshi, Garima; Décembre, Elodie; Nuovo, Célia; Bosseboeuf, Adrien; Bellomo, Alicia; Venet, Manon; Assil, Sonia; Dreux, Marlène

doi:10.1007/978-1-0716-2938-3_21

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The Phenotype Of Heterogeneous DC Subsets Of the Lung1

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2024

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“…These round plasmacytoid cells are present in lower numbers compared to regular cells. pDCs are known for their ability to rapidly produce cytokines such as type I and type III IFNs ( 84 – 88 ), which makes them a crucial subset for managing RILI. pDCs also express major histocompatibility complex II (MHC II) and may function as antigen-presenting cells ( 89 – 92 ).…”

Section: The Phenotype Of Heterogeneous DC Subsets Of the Lungmentioning

confidence: 99%

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Tolerogenic dendritic cells in radiation-induced lung injury

Liu,

Wang,

Han

et al. 2024

Front. Immunol.

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Radiation-induced lung injury is a common complication associated with radiotherapy. It is characterized by early-stage radiation pneumonia and subsequent radiation pulmonary fibrosis. However, there is currently a lack of effective therapeutic strategies for radiation-induced lung injury. Recent studies have shown that tolerogenic dendritic cells interact with regulatory T cells and/or regulatory B cells to stimulate the production of immunosuppressive molecules, control inflammation, and prevent overimmunity. This highlights a potential new therapeutic activity of tolerogenic dendritic cells in managing radiation-induced lung injury. In this review, we aim to provide a comprehensive overview of tolerogenic dendritic cells in the context of radiation-induced lung injury, which will be valuable for researchers in this field.

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Section: The Phenotype Of Heterogeneous DC Subsets Of the Lungmentioning

confidence: 99%

“…Plasmacytoid DCs (pDCs) undergo direct maturation from common DC progenitors (CDPs) in the bone marrow and subsequently migrate to the blood and surrounding lymphoid tissue (83). These round plasmacytoid cells are present in lower numbers compared to regular cells.…”

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confidence: 99%