Tracheal and Endobronchial Involvement in Disseminated Histoplasmosis

Youness, Houssein; Michel, Ross G.; Piťha, Jan; Jones, Kellie; Kinasewitz, Gary T.

doi:10.1378/chest.09-0236

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…However, there is little documentation of direct tracheal submucosal infection. The few cases that exist describe tracheal submucosal involvement in patients with disseminated histoplasmosis or cavitary disease, leading to the proposal that Histoplasma tracheitis may be an indicator of disseminated infection . However, in this case the patient had no other organ manifestations.…”

Section: Case Reportmentioning

confidence: 75%

Nondisseminated histoplasmosis of the trachea

Bhojwani

Hartman

Taylor

et al. 2014

Clinical Respiratory J

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Histoplasma capsulatum can rarely affect the trachea. We report the case of a 68-year-old woman with rheumatoid arthritis on immunosuppressive therapy who presented with fevers, worsening shortness of breath, nonproductive cough and subjective throat hoarseness and fullness. Chest computed tomography demonstrated no tracheal findings. Bronchoscopy found mucosal irregularity, nodularity and vesicular regions in the proximal trachea extending seven centimeters distal to the vocal cords. Also seen was an edematous, exudative left vocal cord with polyps and an ulcerative lesion. Silver staining and culture and wash of the tracheal biopsy revealed Histoplasma capsulatum. She was treated with oral itraconazole then briefly on intravenous amphotericin for rising Histoplasma urinary antigen levels. She continued treatment 24 months following diagnosis with minimal dyspnea. Histoplasma tracheitis has been proposed as an indicator of disseminated infection. However, our patient did not demonstrate other organ manifestations. Histoplasma tracheitis should be considered in a differential diagnosis of tracheal lesions even in the absence of systemic involvement.

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Section: Case Reportmentioning

confidence: 75%

Nondisseminated histoplasmosis of the trachea

Bhojwani

Hartman

Taylor

et al. 2014

Clinical Respiratory J

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“…Description of tracheal involvement in disseminated cases is also scarce in the literature. A case reported from the United States by Youness H et al described a 53‐year‐old man with tracheal and endobronchial involvement along with disseminated histoplasmosis found in autopsy 4 . Since autopsy is not done in all cases of disseminated infection, it is possible that the prevalence of tracheal involvement in disseminated cases would be much higher.…”

Section: Figurementioning

confidence: 99%

Unusual cause of hoarse voice: Laryngotracheal histoplasmosis in renal transplant patient

Tiwari

Bhandari

Gupta

et al. 2020

Transplant Infectious Dis

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“…[ 9 ] Disseminated histoplasmosis presenting as diffuse tracheal nodularity and ulcerative growths has been described in some case reports. [ 10 ] To the best of our knowledge, histoplasmosis presenting as well-defined cutaneous nodules and isolated tracheal mass has not been reported previously in the literature.…”

Section: Pathological Diagnosismentioning

confidence: 99%

A 44-year-old man with hemoptysis

et al. 2018

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A 44-year-old man with background history of diffuse cutaneous systemic sclerosis and dilated cardiomyopathy receiving immunosuppressive medications, presented with a 2-month history of cough and streaky hemoptysis. Clinicoradiological features were consistent with an endotracheal mass. Subsequently, the patient developed nodular skin lesions and the tracheal mass increased in size causing central airway obstruction. This clinicopathologic conference discusses the clinical and radiological differential diagnoses of such a clinical presentation and their management options.

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Tracheal and Endobronchial Involvement in Disseminated Histoplasmosis

Cited by 7 publications

References 12 publications

Nondisseminated histoplasmosis of the trachea

Nondisseminated histoplasmosis of the trachea

Unusual cause of hoarse voice: Laryngotracheal histoplasmosis in renal transplant patient

A 44-year-old man with hemoptysis

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