Synapse
 1999
DOI: 10.1002/(sici)1098-2396(199901)31:1<5::aid-syn2>3.0.co;2-d
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Tracers for imaging melanin with positron emission tomography

Bernard Sadzot1,
Jeffrey H. Sheldon
2
,
John E. Flesher
3
et al.

Abstract: The melanin binding properties of six radioligands were determined in vivo in the eyes of pigmented mice. Binding in the eyes of nonpigmented mice was used to assess nonmelanin binding characteristics. Of these radioligands, 3H-N-methylspiperone showed the best uptake and gave the best signal-to-noise ratio at all time points examined. Its binding appeared essentially irreversible. A PET study with 11C-N-methylspiperone was therefore carried out in a patient with a small ocular melanoma. Increased uptake of 11… Show more

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Cited by 6 publications

(3 citation statements)
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“…With this in mind, it seems reasonable to assume that treatment-related extinguished SUV may correlate to both local control and loss of ability to metastasize. Additionally, it should be considered that [ 18 F]FDG is relatively nonspecific for melanoma and that new melanoma-directed PET/CT radiopharmaceuticals will become available (38).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…With this in mind, it seems reasonable to assume that treatment-related extinguished SUV may correlate to both local control and loss of ability to metastasize. Additionally, it should be considered that [ 18 F]FDG is relatively nonspecific for melanoma and that new melanoma-directed PET/CT radiopharmaceuticals will become available (38).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…8 18 F-FDG-positron emission tomography (PET) studies of uveal melanomas revealed variable glucose consumption among ocular lesions, 9,10 thus enabling the visualization only of some larger-sized lesions. PET tracers, such as 11 C-N-methylspiperone, 11 possibly binding to melanin, are under investigation in ocular melanoma.…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…C-Methionine, 379 125 I-alpha-methyl-tyrosine (AMT), 18 F-DOPA, 380 18 F-FLT, 381 11 C-N-methylspiperone, 382 and radiolabeled alpha-melanocyte-stimulating hormone 383 are some of the new promising radiopharamaceuticals in the field of melanoma.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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