Trace Elements in the Lung Tissue Affected by Sarcoidosis

Денисова, О А; Chernogoryuk, G. E.; Baranovskaya, N. V.; Рихванов, Леонид Петрович; Шефер, Н. А.; Chernjavskaya, Galina; Palchikova, Inna; Калачева, Т. П.

doi:10.1007/s12011-019-01915-z

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…Calcium carbonate was the source of the birefringent material in the other two [15]. Denisova et al conducted a comparable study whereby lung tissue of 76 sarcoidosis patients and 30 controls was analyzed for the presence of macro and trace elements [16]. Tissue of the sarcoidosis patients was found to have a 2–10 fold higher presence of calcium, chromium, iron, cobalt, cesium, europium, lutetium, hafnium, gold, uranium, and thorium [16].…”

Section: Exposure To Metals or Silicamentioning

confidence: 99%

“…Denisova et al conducted a comparable study whereby lung tissue of 76 sarcoidosis patients and 30 controls was analyzed for the presence of macro and trace elements [16]. Tissue of the sarcoidosis patients was found to have a 2-10 fold higher presence of calcium, chromium, iron, cobalt, cesium, europium, lutetium, hafnium, gold, uranium, and thorium [16]. Also, Catinon et al [17] studied the presence of inorganic agents in the lungs of sarcoidosis patients and in sex, age, and tobacco use matched healthy controls.…”

Section: Histopathological Exposure Assessmentmentioning

confidence: 99%

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The emerging role of inorganic elements as potential antigens in sarcoidosis

Beijer

Veltkamp

2021

Current Opinion in Pulmonary Medicine

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Purpose of reviewPrevious studies mainly described a role for organic agents as possible triggers for sarcoidosis. In this review, we address recent studies suggesting a possible role for inorganic elements, such as metals or silica in sarcoidosis pathogenesis.Recent findingsSeveral epidemiological papers suggest that inorganic agents, either by environmental exposures or occupational activities, could trigger sarcoidosis. Association between inorganics and sarcoidosis is also described in several recently published case reports and studies demonstrating immunological sensitization to inorganic agents in sarcoidosis patients.Studies comparing chronic beryllium disease (CBD) and sarcoidosis suggest that although antigenic triggers may differ, underlying processes may be comparable.Besides the fact that a growing number of studies show a possible role for inorganic triggers, it is also suggested that inorganic triggered sarcoidosis may result in a more severe phenotype, including pulmonary fibrosis.SummaryWe can use the knowledge already gained on CBD pathogenesis to conduct further research into role of inorganics, such as metals and silica as antigens in sarcoidosis. Given the importance of a lymphocyte proliferation test (LPT) in diagnosing CBD, it seems obvious to also implement this test in the diagnostic work-up of sarcoidosis to identify patients with an inorganic antigenic trigger of their disease.

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Section: Exposure To Metals or Silicamentioning

confidence: 99%

Section: Histopathological Exposure Assessmentmentioning

confidence: 99%

The emerging role of inorganic elements as potential antigens in sarcoidosis

Beijer

Veltkamp

2021

Current Opinion in Pulmonary Medicine

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“…Sarcoidosis in not a rare condition in Africa (Awotedu et al, 1987;Kaloga et al, 2015), the apparent infrequency of reporting being probably a result of misdiagnosis (as, e.g., tuberculosis) (Morar and Feldman, 2015a;Morar and Feldman, 2015b). Further research is therefore necessary in Africa to unravel the various clinical aspects of this mysterious and complex disease Exposure to toxic metals and rare earth elements (REEs) in the environment - Newman, 1998;Beijer et al, 2020;Denisova et al, 2020;Metal dusts -Judson, 2020;Crystalline silica -Arkema and Cozier, 2018; Industrial exposure to Be - Culver et al, 2007. Since low dose metal particles can induce monocyte/macrophage survival (See e.g., Lacey et al, 2009), as recently as 2021, Lepzien et al (2021) went on to show that monocytes could be a vital marker in understanding the inflammatory process of sarcoidosis.…”

Section: Consent To Participatementioning

confidence: 99%

The position of geochemical variables as causal co-factors of diseases of unknown aetiology

Davies

2021

Preprint

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The term diseases of unknown aetiology (DUA) or idiopathic diseases refers to diseases that are of uncertain or unknown cause or origin. Among plausible geoenvironmental (co-)factors in causation of DUA, this article focusses on the entry of trace elements, including metals and metalloids into biological systems, and their involvement in humoral and cellular immune responses, representing potentially toxic agents with implications as co-factors for certain DUA. Several trace elements/metals/metalloids (micronutrients) play vital roles as cofactors for essential enzymes and antioxidant molecules, thus, conferring protection against disease. However, inborn errors of trace element/metal/metalloid metabolisms can occur to produce toxicity, such as when there are basic defects in the element transport mechanism. Ultimately, it is the amount of trace element, metal or metalloid that is taken up, its mode of accumulation in human tissues, and related geomedical attributes such as the chemical form and bioavailability that decisively determine whether the exerted effects are toxic or beneficial. Several case descriptions of DUA that are common worldwide are given to illustrate our knowledge so far of how trace element/metal/metalloid interactions in the immune system may engender its dysregulation and be implicated as causal co-factors of DUA.

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“…Sarcoidosis in not a rare condition in Africa—[ 232 , 233 ], the apparent infrequency of reporting being probably a result of misdiagnosis (as, e.g., tuberculosis)—[ 234 , 235 ]. Further research is therefore necessary in Africa to unravel the various clinical aspects of this mysterious and complex disease Exposure to toxic metals and rare earth elements (REEs) in the environment—[ 236 – 238 ]; Metal dusts—[ 239 ]; Crystalline silica—[ 231 ]; Industrial exposure to Be—[ 240 ] Since low dose metal particles can induce monocyte / macrophage survival (See e.g., Lacey et al—[ 241 ]), as recently as 2021, Lepzien et al—[ 242 ] went on to show that monocytes could be a vital marker in understanding the inflammatory process of sarcoidosis Geographic clustering of disease in many parts of the world has long been noted, [e.g., in the US (Sartwell and Edwards—[ 243 ]); this (clustering) has ignited further speculations concerning weather, soil, and foliage in the pathogenesis of sarcoidosis. More recently (2019), Ramos-Casals et al—[ 244 ] asserted that local weather is a key environmental factor influencing the incidence of sarcoidosis in a specific geographical area, with the peak of diagnosed cases following a specific seasonal distribution pattern The causes of sarcoidosis are still unknown and epidemiological data are often discordant—[ 245 , 246 ] Although the aetiology of this condition remains uncertain, Ganeshan et al [ 247 ] consider that the role of environmental and genetic factors may be considerable in any proposed causative mechanism According to Ahmadzai et al—[ 248 ], in sarcoidosis, conventional sampling techniques or cultures of non-caseating granulomas cannot detect tissue micro-organisms; although as Newman earlier (1998)—[ 236 ] proposed, clinicians should use a systematic approach to investigating the occupational and environmental history and immunologic responses of patients with sarcoidosis, for discriminating metal-induced granulomatosis from sarcoidosis 19.…”

Section: Introductionmentioning

confidence: 99%

“…Exposure to toxic metals and rare earth elements (REEs) in the environment—[ 236 – 238 ]; Metal dusts—[ 239 ]; Crystalline silica—[ 231 ]; Industrial exposure to Be—[ 240 ]…”

Section: Introductionmentioning

confidence: 99%

The position of geochemical variables as causal co-factors of diseases of unknown aetiology

Davies

2022

SN Appl. Sci.

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The term diseases of unknown aetiology (DUA) or idiopathic diseases is used to describe diseases that are of uncertain or unknown cause or origin. Among plausible geoenvironmental co-factors in causation of DUA, this article focusses on the entry of trace elements, including metals and metalloids into humans, and their involvement in humoral and cellular immune responses, representing potentially toxic agents with implications as co-factors for certain DUA. Several trace elements/metals/metalloids (micronutrients) play vital roles as co-factors for essential enzymes and antioxidant molecules, thus, conferring protection against disease. However, inborn errors of trace element/metal/metalloid metabolisms can occur to produce toxicity, such as when there are basic defects in the element transport mechanism. Ultimately, it is the amount of trace element, metal or metalloid that is taken up, its mode of accumulation in human tissues, and related geomedical attributes such as the chemical form and bioavailability that decisively determine whether the exerted effects are toxic or beneficial. Several case descriptions of DUA that are common worldwide are given to illustrate our knowledge so far of how trace element/metal/metalloid interactions in the immune system may engender its dysregulation and be implicated as causal co-factors of DUA. Article highlights The importance of a proper understanding of geochemical perturbations in human metabolisms is emphasised It is proferred that such an understanding would aid greatly in the decipherment of diseases of unknown aetiology (DUA) The thesis presented may pave the way towards better diagnosis and therapy of DUA

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Trace Elements in the Lung Tissue Affected by Sarcoidosis

Cited by 5 publications

References 20 publications

The emerging role of inorganic elements as potential antigens in sarcoidosis

The emerging role of inorganic elements as potential antigens in sarcoidosis

The position of geochemical variables as causal co-factors of diseases of unknown aetiology

The position of geochemical variables as causal co-factors of diseases of unknown aetiology

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