Trace Contamination of Over-the-Counter Androstenedione and Positive Urine Test Results for a Nandrolone Metabolite

Abstract

Our study suggests that trace contamination of androstenedione with 19-norandrostenedione is sufficient to cause urine test results positive for 19-norandrosterone, the standard marker for nandrolone use. Oral steroid doses as small as 10 microg are absorbed and excreted in urine. Some brands of androstenedione are grossly mislabeled. Careful analysis of androstenedione preparations is recommended in all studies of its biological effects. JAMA. 2000;284:2618-2621.

Effects of dietary supplements on selected hematological and biochemical parameters of Pakistani athletes

“…In present study, an increase in the plasma electrolyte was seen in athletes who used supplements as compared to those who do not use supplements like control group which is in relation to the previous studies [44][45][46][47] where Creatine supplementation causes electrolyte disturbances and renal damages.…”

Urinary Nandrolone Metabolite Detection after Ingestion of a Nandrolone Precursor

“…The recovery of the ingested dose was highly variable, ranging from about 11 -84% across all subjects during the three trials. Similar findings have been reported in several studies investigating the excretion patterns of urinary nandrolone metabolites (3,4). There was a clear inverse relationship between the quantity of 19-norandrostenedione ingested and total percentage recovery of 19-NA + 19-NE, but this association was not apparent when values under the limit of quantification were excluded from this analysis.…”

“…Peak urine 19-NA concentrations were highly variable, but an individual peak 19-NA concentration of 28.0 ng/mL was recorded and the greatest 19-NA levels were observed in either the first or second void following ingestion of the supplement. Several previous studies have also reported similar findings following the ingestion of dietary supplements or over-the-counter medicines either known to contain nandrolone, or its precursors, or where the presence of these substances was undeclared (3)(4)(5)(6)(7)16).…”

Effects of High-Intensity Exercises on 13C-Nandrolone Excretion in Trained Athletes

“…[13][14][15][16][17] The use of contaminated supplements often leads to low 19-NA and 19-NE urinary concentrations close to the values measured in this study. Because of significant interindividual variability, no clear conclusions can be drawn about possible consequences of physical effort on nandrolone metabolites excretion in urine.…”