Biochemical Pharmacology volume 78, issue 9, P1095-1104 2009 DOI: 10.1016/j.bcp.2009.05.031 View full text
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Zhihua Xie, Gregory M. Miller

Abstract: Brain monoaminergic systems play critical roles in mood, cognition, emotion, reward, learning and attention, and aberrance in brain monoaminergic activity is associated with a variety of neuropsychiatric disorders/diseases. The present commentary focuses on trace amine-associated receptor 1 (TAAR1) and its potential regulatory roles in brain monoaminergic systems. TAAR1 was discovered in 2001 and has been established to be a G-protein-coupled receptor signaling through the cAMP pathway. This receptor is activ…

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