Trabecular bone score in patients with chronic kidney disease

Rampersad, Christie; Whitlock, Reid; Leslie, William D.; Rigatto, Claudio; Komenda, Paul; Bohm, Clara; Hans, Didier; Tangri, Navdeep

doi:10.1007/s00198-020-05458-1

Cited by 22 publications

(22 citation statements)

References 38 publications

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“…TBS may be particularly useful in some types of secondary osteoporosis, where bone quality is especially affected [7]. Several studies have shown the usefulness of TBS in assessing bone microarchitecture in GIO [8], osteoporosis associated with diabetes mellitus [9], primary hyperparathyroidism [10], and chronic kidney disease [11]. More importantly, TBS seems to be more sensitive than BMD for the detection of fracture risk related to GCs therapy [12].…”

Section: Introductionmentioning

confidence: 99%

Clinical Utility of Trabecular Bone Score (TBS) in Fracture Risk Assessment of Patients with Rheumatic Diseases Treated with Glucocorticoids

et al. 2021

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Chronic glucocorticoid therapy is associated with osteoporosis and can cause fractures in up to 50% of patients. Increased risk of fractures in patients with glucocorticoid-induced osteoporosis does not result only from the decreased bone mineral density (BMD) but also bone microarchitecture deterioration. Trabecular bone score (TBS) is a method complementary to DXA, providing additional information about trabecular bone structure. The aim of this study was to assess the clinical utility of TBS in fracture risk assessment of patients treated with glucocorticoids. Patients with rheumatic diseases treated with glucocorticoids for at least 3 months were enrolled. All recruited patients underwent DXA with additional TBS assessment. We analyzed the frequency of osteoporosis and osteoporotic fractures and assessed factors that might be associated with the risk of osteoporotic fractures. A total of 64 patients were enrolled. TBS and TBS T-score values were significantly lower in patients with osteoporosis compared to patients without osteoporosis. Low energy fractures occurred in 19 patients. The disturbed bone microarchitecture was found in 30% of patients with fractures without osteoporosis diagnosis based on BMD. In the multivariate analysis, only TBS and age were significantly associated with the occurrence of osteoporotic fractures. TBS reflects the influence of glucocorticoid therapy on bone quality better than DXA measured BMD and provides an added value to DXA in identifying the group of patients particularly prone to fractures.

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Section: Introductionmentioning

confidence: 99%

Clinical Utility of Trabecular Bone Score (TBS) in Fracture Risk Assessment of Patients with Rheumatic Diseases Treated with Glucocorticoids

et al. 2021

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“…Our possible speculation is that such age-specific phasic changes of eGFR in the 40s, 60s and 70s would derive from increasing numbers of atherosclerotic risk factors, 1 changes in sex hormones 11,12 and changes in bone metabolism. 13 There were several limitations in our study. First, our findings were based on a single-center cohort of a cardiovascular specialized hospital, which should be evaluated in multicenter studies or in other types of cohorts including healthy subjects.…”

Section: Dear Editormentioning

confidence: 90%

Decline of estimated glomerular filtration rate has triphasic changes according to age

Suzuki

Yamashita

Otsuka

et al. 2020

Geriatrics Gerontology Int

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“…Nor can changes in TBS be considered an adequate measure of improvements in bone quality or risk reduction with anabolic agents. 23,24 Distal radius and tibia high-resolution peripheral quantitative computed tomography (HR-pQCT) provides in vivo assessment of bone geometry, true 3-dimensional (volumetric) BMD, and microarchitecture at a resolution of 60 to 82 mm (Fig 1). 25 It is noninvasive and can define microarchitectural abnormalities.…”

Section: Differential Diagnosis: Osteoporosis Versus Renal Osteodystrophymentioning

confidence: 99%

Osteoporosis and Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD): Back to Basics

Pazianas

Miller

2021

American Journal of Kidney Diseases

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Trabecular bone score in patients with chronic kidney disease

Cited by 22 publications

References 38 publications

Clinical Utility of Trabecular Bone Score (TBS) in Fracture Risk Assessment of Patients with Rheumatic Diseases Treated with Glucocorticoids

Clinical Utility of Trabecular Bone Score (TBS) in Fracture Risk Assessment of Patients with Rheumatic Diseases Treated with Glucocorticoids

Decline of estimated glomerular filtration rate has triphasic changes according to age

Osteoporosis and Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD): Back to Basics

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