TPE-based fluorescent probe for dual channel imaging of pH/viscosity and selective visualization of cancer cells and tissues

Yang, Linlin; Gu, Pengli; Fu, Aoxiang; Xi, Yang; Cui, Shaoli; Ji, Liguo; Li, Lili; Ma, Ning; Wang, Qingzhi; He, Guangjie

doi:10.1016/j.talanta.2023.124862

Cited by 9 publications

(1 citation statement)

References 38 publications

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“…The pressing need to unravel the cooperative effects of these molecular conjugations has sparked intense deliberation among researchers. At its core, the fused xanthene fluorophore boasts a quintessential xanthene nucleus that is further enriched by strategically incorporated supplementary ring systems (see Figure 1a) [45][46][47][48]. To enhance both photostability and photoluminescence in these xanthene-based moieties, methodologies like nitrogen stabilization via cyclization have proven paramount.…”

Section: Introductionmentioning

confidence: 99%

New Fluorophore and Its Applications in Visualizing Polystyrene Nanoplastics in Bean Sprouts and HeLa Cells

Xing,

Gao,

Wang

et al. 2023

Molecules

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In the domain of environmental science, pollutants of nanoscale plastic dimensions are acknowledged as subjects of intricate significance. Such entities, though minuscule, present formidable challenges to ecological systems and human health. The diminutive dimensions of these contaminants render their detection arduous, thus demanding the inception of avant-garde methodologies. The present manuscript postulates the employment of the tetraphenylethylene functional group with a fused xanthene (TPEF), a distinguished fluorophore, as an exemplary system for the discernment of nanoplastic particulates. The synthesis and characterization of TPEF have been exhaustively elucidated, revealing its paramount fluorescence attributes and inherent affinity for interaction with nanoplastics. When subjected to comparison with TPEF, nanoplastics are observed to manifest a more pronounced fluorescent luminescence than when associated with the conventional Nile Red (NR). Particularly, the TPEF has shown exceptional affinity for polystyrene (PS) nanoplastics. Further, the resilience of nanoplastics within the hypocotyl epidermis of soybeans, as well as their persistence in mung bean sprouts subsequent to rigorous rinsing protocols, has been meticulously examined. Additionally, this investigation furnishes empirical data signifying the existence of nano-dimensional plastic contaminants within HeLa cellular structures. The urgency of addressing the environmental ramifications engendered by these diminutive yet potent plastic constituents is emphatically highlighted in this manuscript. TPEF paves the way for prospective explorations, with the aspiration of devising efficacious mitigation strategies. Such strategies might encompass delineating the trajectories undertaken by nanoplastics within trophic networks or their ingress into human cellular architectures.

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Section: Introductionmentioning

confidence: 99%

New Fluorophore and Its Applications in Visualizing Polystyrene Nanoplastics in Bean Sprouts and HeLa Cells

Xing,

Gao,

Wang

et al. 2023

Molecules

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Functional Materials for Subcellular Targeting Strategies in Cancer Therapy: Progress and Prospects

Cheng,

Qu,

Jiang

et al. 2023

Advanced Materials

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Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment. However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of cancer, genomic instability, and the formation of an immunosuppressive tumor microenvironment. Functional materials possess unique biological properties such as long circulation times, tumor‐specific targeting, and immunomodulation. The combination of functional materials with natural substances and nanotechnology has led to the development of smart biomaterials with multiple functions, high biocompatibilities, and negligible immunogenicities, which can be used for precise cancer treatment. Recently, subcellular structure‐targeting functional materials have received particular attention in various biomedical applications including the diagnosis, sensing, and imaging of tumors and drug delivery. Subcellular organelle‐targeting materials can precisely accumulate therapeutic agents in organelles, considerably reduce the threshold dosages of therapeutic agents, and minimize drug‐related side effects. This review provides a systematic and comprehensive overview of the research progress in subcellular organelle‐targeted cancer therapy based on functional nanomaterials. Moreover, it explains the challenges and prospects of subcellular organelle‐targeting functional materials in precision oncology. We believe that our review will serve as an excellent cutting‐edge guide for researchers in the field of subcellular organelle‐targeted cancer therapy.This article is protected by copyright. All rights reserved

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A near-infrared fluorescent probe with viscosity sensitivity in lysosome for cancer visualization

Wang,

Fu,

Tan

et al. 2023

Anal Bioanal Chem

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TPE-based fluorescent probe for dual channel imaging of pH/viscosity and selective visualization of cancer cells and tissues

Cited by 9 publications

References 38 publications

New Fluorophore and Its Applications in Visualizing Polystyrene Nanoplastics in Bean Sprouts and HeLa Cells

New Fluorophore and Its Applications in Visualizing Polystyrene Nanoplastics in Bean Sprouts and HeLa Cells

Functional Materials for Subcellular Targeting Strategies in Cancer Therapy: Progress and Prospects

A near-infrared fluorescent probe with viscosity sensitivity in lysosome for cancer visualization

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