TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers

Sonoyama, Takayuki; Sakai, Akiko; Mita, Yuichiro; Yasuda, Yukiko; Kawamoto, Hirofumi; Yagi, T.; Yoshioka, Masao; Mimura, Tetsushige; Nakachi, Kei; Ouchida, Mamoru; Yamamoto, Kazuhide; Shimizu, Kenji

doi:10.3892/mmr.2011.449

Cited by 20 publications

(18 citation statements)

References 24 publications

(27 reference statements)

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“…Furthermore, the Pro/Pro frequency in PDAC was higher in this study using FFPE tissues (65.6%) than in the studies of Sonoyama et al . (14.6%) [9] or Nacaeeati et al . (7.9%) [30] using blood samples.…”

Section: Discussionmentioning

confidence: 99%

“…This finding was subsequently validated through in vitro DNA-protein binding and reporter plasmid cell-based assays [4]. These polymorphisms were investigated previously in peripheral blood samples from PDAC patients [9–11]. To our knowledge, in PDAC, no study has examined TP53 codon 72 and only one study has examined the MDM2 SNP 309 [12] polymorphism using formalin-fixed paraffin-embedded (FFPE) specimens.…”

Section: Introductionmentioning

confidence: 99%

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Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma

et al. 2015

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Single-nucleotide polymorphisms (SNPs) of TP53 (codon 72, rs1042522) and MDM2 promoter (SNP 309, rs2279744) have been associated with risk for various human cancers. However, studies analyzing these polymorphisms in pancreatic ductal adenocarcinoma (PDAC) are lacking. We investigated TP53 codon 72 and MDM2 SNP 309 polymorphisms in 32 patients with PDAC, 16 patients with chronic pancreatitis (CP), and 32 normal controls, using formalin-fixed paraffin-embedded tissue. We also examined TP53 and MDM2 protein immunohistochemistry (IHC) to assess the involvement of these differences in malignant transformation and disease progression. TP53 Pro/Pro genotype was significantly more frequent in PDAC patients than in controls (65.6 vs. 15.6%, p < 0.001) and no significant difference was found between CP patients (37.5%) and controls. In MDM2 SNP 309, there were no significant differences among the three groups. Based on the Kaplan-Meier analysis, overall survival was significantly shorter in MDM2 G/G genotypes compared with other genotypes (G/T and T/T) (359 vs. 911 days, p = 0.016) whereas no significant differences in TP53 genotypes were observed (638 vs. 752 days, p = 0.471). Although TP53 IHC was frequent in PDAC patients (53.1%), TP53 and MDM2 protein expression was not correlated with polymorphisms. Our study demonstrated TP53 codon 72 polymorphism is potentially a genetic predisposing factor while MDM2 SNP 309 polymorphism might be useful in predicting survival outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma

et al. 2015

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“…On the other hand, a significant interaction has been reported between TP53 Pro/Pro genetic polymorphism and smoking in esophageal squamous cell carcinoma (OR = 5.29, 95% CI = 2.91 -9.61) (28). In pancreatic cancer, it was reported that TP53 Pro/Pro genotype significantly increases the risk of cancer among males, particularly among heavy smokers and excessive alcohol drinkers (29). Liu et al also reported that TP53Pro allele increases the risk of squamous cell carcinoma of the lung mainly in heavy smokers (OR = 3.84, 95% CI = 1.46 -10.1) (30).…”

Section: Discussionmentioning

confidence: 99%

TP53 Codon 72 Genetic Polymorphism, rs1042522, Modifies the Association Between Tobacco Smoking and Breast Cancer Risk

Moradinasab

Ostovar

Nabipour

et al. 2017

Iran Red Crescent Med J

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Background: TP53 tumor suppressor gene participates in several pathways involving in carcinogenesis such as cell cycle control, DNA repair, and apoptosis. A common TP53 SNP (guanine/cytosine nucleotide substitution at codon 72), rs1042522, affects the function of p53 protein and may influence tumor behavior in response to environmental carcinogens. Objectives: This study investigates the association between TP53 codon 72 polymorphisms, tobacco smoking, and breast cancer risk in southern Iranian women from Bushehr. Methods: A case-control study was conducted on 144 cases with histologically confirmed invasive breast carcinoma and 162 randomly selected healthy controls with no previous cancer history in their family. TP53 codon 72 genotype was determined by using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique. Results: Analysis revealed that smoking frequency was significantly higher in cases compared to controls (OR = 2.31, 95%CI = 1.33-3.99, P = 0.003) and the association between smoking and breast cancer was only significant for individuals with Arg/Pro genotype (OR = 3.23, 95% CI = 1.47 -7.06, P = 0.003). On the other hand, there was no statistically considerable difference in the allele and genotype distribution between cases and controls. Conclusions: These results should be confirmed in larger studies, but suggest that TP53 Arg/Pro genotype modifies the risk of breast cancer in tobacco smokers and causes significantly more susceptibility to breast cancer due to smoking.

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“…Moreover, a mutation occurring in the same location can initiate different cancers depending on the geographical location, ethnic background, and/or gender of the patient. Sonoyama et al investigated P53 proline mutation and found that it caused pancreatic cancer in males, 29 whereas the same mutation decreased the risk of breast cancer in Arab women. 30 Gene markers can assist in the determination of subtypes of cancer.…”

Section: Disease Biomarkers and Postgenomic Technology Cancer Markersmentioning

confidence: 96%

Molecular biosensors: promising new tools for early detection of cancer

Altıntaş¹,

Tothill²

2015

NDD

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TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers

Cited by 20 publications

References 24 publications

Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma

Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma

TP53 Codon 72 Genetic Polymorphism, rs1042522, Modifies the Association Between Tobacco Smoking and Breast Cancer Risk

Molecular biosensors: promising new tools for early detection of cancer

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