2007
DOI: 10.1590/s0100-879x2006005000174
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TP53 codon 72 polymorphism as a risk factor for cardiovascular disease in a Brazilian population

Abstract: TP53, a tumor suppressor gene, has a critical role in cell cycle, apoptosis and cell senescence and participates in many crucial physiological and pathological processes. Identification of TP53 polymorphism in older people and age-related diseases may provide an understanding of its physiology and pathophysiological role as well as risk factors for complex diseases. TP53 codon 72 (TP53:72) polymorphism was investigated in 383 individuals aged 66 to 97 years in a cohort from a Brazilian Elderly Longitudinal Stu… Show more

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Cited by 2 publications
(7 citation statements)
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“…A common polymorphism in TP53, Pro72Arg, has been the focus of analysis in CAD; nevertheless, the results were discordant [11,12] . Thus, in the present study, we have investigated the possible association between the Pro72Arg polymorphism and CAD in Chilean individuals.…”
Section: Discussionmentioning
confidence: 99%
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“…A common polymorphism in TP53, Pro72Arg, has been the focus of analysis in CAD; nevertheless, the results were discordant [11,12] . Thus, in the present study, we have investigated the possible association between the Pro72Arg polymorphism and CAD in Chilean individuals.…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, the TP53 codon 72 polymorphism seems to contribute to a genetically determined variability in atherosclerosis. However, Manfredi et al [13] , Smith et al [11] and Alkhalaf et al [12] did not find any association between the Pro72Arg polymorphism and the occurrence of CAD in Italian, Brazilian and Kuwaiti subjects, respectively, but Manfredi et al [13] and Smith et al [11] detected an association between the 72Arg allele and lower levels of HDL-C. The reasons for these discrepancies include the differences in the study design, the definition of inclusion and exclusion criteria, the number of participants, and the different ethnicities of subjects as show in table 4 .…”
Section: Discussionmentioning
confidence: 99%
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“…It is of interest that P72 homozygosity has been found to protect against increases in glucose levels during oral glucose tolerance test in one study of human subjects [44]. Also, the p53 codon 72 polymorphism has been associated with risk for type 2 diabetes, based on recent epidemiologic studies [45][46][47][48][49]. The combined data demonstrate that the livers of R72 mice exhibit increased macrophage infiltration and inflammatory signaling following a HFD.…”
Section: Serum Adipokine Levels In Hupki Mice Subjected To a Hfdmentioning
confidence: 99%