Toxoplasma gondii infection and a history of surgery: A case control seroprevalence study

Abstract

We determined the association between having a history of surgery and the seroreactivity to T. gondii. An age- and gender-matched case-control study of 391 subjects with a history of surgery and 391 subjects without this history was performed. Sera of subjects were analyzed for detection of anti-T. gondii immunoglobulin G (IgG) and M (IgM) antibodies using enzyme-linked immunoassays. Anti-T. gondii IgG antibodies were found in 25 (6.4%) of the 391 cases and in 21 (5.4%) of the 391 controls (odds ratio [OR] = 1.29; 95% confidence interval [CI]: 0.66–2.18; P = 0.54). The frequency of cases with high IgG antibody levels (10/25: 40.0%) was equal to that found in controls (8/21: 38.1%) (OR = 1.08; 95% CI: 0.32–3.56; P = 0.89). Of the 25 anti-T. gondii IgG antibody seropositive cases, 5 (16.0%) were also positive for anti-T. gondii IgM antibodies. Meanwhile, of the 21 anti-T. gondii IgG antibody seropositive controls, 4 (19.0%) were also positive for anti-T gondii IgM antibodies (OR = 0.81; 95% CI: 0.17–3.72; P = 0.80). Logistic regression showed that only the variable "hysterectomy" was associated with T. gondii seropositivity (OR = 4.6; 95% CI: 1.6–13.4; P = 0.005). Results suggest that having a history of surgery is not an important risk factor for infection with T. gondii. However, the link between T. gondii infection and hysterectomy should be further investigated.

Association between Toxoplasma gondii infection and history of blood transfusion: a case-control seroprevalence study

“…3 However, individuals who develop toxoplasmosis, the disease caused by T. gondii , may present several well-recognized clinical features: lymphadenopathy, chorioretinitis, and meningoencephalitis. 4,5 In addition, infection with T. gondii has been associated with heart disease, 6,7 schizophrenia, 8,9 depression, 10,11 and mixed anxiety and depression. 12 Immunocompromised individuals infected with T. gondii may develop disseminated and life-threatening disease.…”

Determine the IgG and IgM antibodies created against T. gondii infections using the ELISA method in diabetic pregnant women in compared with non -diabetic pregnant women in Sanandaj, Kurdistan, west of Iran

“…Blood transfusion and organ transplantation have also been mentioned as possible infection risk factors (3). This parasite can lead to chronic infection in individuals, serious problems and death in immune compromised patients, hydrocephalus in congenitally infected newborns, intrauterine fetal death, and spontaneous abortion during pregnancy (4).Several studies found a positive correlation between toxoplasmosis with schizophrenia (5), and depression (6).…”