Toxisch epidermale Nekrolyse

Abstract

Toxic epidermal necrolysis is a rare but life-threatening exfoliating disease of the skin and mucous membranes, commonly considered a drug sensitivity reaction. In this review of the literature we discuss the epidemiology, etiology, and pathology. We show diagnostic problems and current treatment strategies. Many of the problems associated with the disease, such as wound infection, sepsis, nutritional support, and pain management, are similar to problems in severely burned patients. Burn centers provide optimal logistics and knowledge to diagnose and treat this serious disease entity.

Does hypernatremia impact mortality in Toxic Epidermal Necrolysis?

“…In a life-threatening disease like TEN we strongly recommend this approach to optimize hemodynamic monitoring. Early transferral of TEN patients to regional Burn Units for critical care management and optimized wound care has been shown to have a positive effect on survival [5]. …”

“…Skin biopsy is the only reliable method to confirm the diagnosis of TEN (separation of the epidermo-dermal junction) in correlation with the macroscopic clinical presentation of the skin [4]. Burn center treatment is recommended in TEN-patients, because of the extensive cutaneous defects [5]. …”