Toxicology studies of linear alkylbenzene sulphonate (LAS) in rhesus monkeys I. Simultaneous oral and subcutaneous administration for 28 days

Lineare Alkylbenzolsulfonate C10–14 [MAK Value Documentation in German language, 2007]

“…Fibrose an den Injektionsstellen war in Inzidenz und Schweregrad dosisabhängig, begleitet von Blutung und Nekrose. Ophthalmoskopie, Laboranalyse von Blut (Differentialblutbild, Blutkörperchensenkung, Prothrombinindex, Blutzucker, Harnstoff, alkalische Phosphatase, Alaninaminotransferase (ALT), Leucin-Aminopeptidase, Bilirubin, Natrium und Kalium) und Urin, Organgewichte und Histologie von Gehirn, Hypophyse, Herz, Lunge, Leber, Milz, Pankreas, Thymus, Prostata, Uterus, Niere, Nebenniere, Schilddrüse und Gonaden zeigten bei allen Dosen keine behandlungsbedingten Änderungen(Heywood et al 1978). Die Dosis von 30 mg/kg KG und Tag oral und simultan subkutan 0,1 mg/kg KG und Tag ist als NOAEL anzusehen.…”

Lineare Alkylbenzolsulfonate C10–14 [MAK Value Documentation in German language, 2007]

“…Fibrose an den Injektionsstellen war in Inzidenz und Schweregrad dosisabhängig, begleitet von Blutung und Nekrose. Ophthalmoskopie, Laboranalyse von Blut (Differentialblutbild, Blutkörperchensenkung, Prothrombinindex, Blutzucker, Harnstoff, alkalische Phosphatase, Alaninaminotransferase (ALT), Leucin-Aminopeptidase, Bilirubin, Natrium und Kalium) und Urin, Organgewichte und Histologie von Gehirn, Hypophyse, Herz, Lunge, Leber, Milz, Pankreas, Thymus, Prostata, Uterus, Niere, Nebenniere, Schilddrüse und Gonaden zeigten bei allen Dosen keine behandlungsbedingten Änderungen(Heywood et al 1978). Die Dosis von 30 mg/kg KG und Tag oral und simultan subkutan 0,1 mg/kg KG und Tag ist als NOAEL anzusehen.…”

Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics

“…Industrial Bio-Test Laboratories, Inc 40 incorporated SDDBS (0.02%, 0.10%, or 0.50%) into the feed of Beagle dogs (n ¼ 6; 3 males and 3 females) for 104 weeks. Due to poor palatability, the high dose was adjusted to 0.10% in the feed and the remaining dose was administered by capsule (the timing of this adjustment was not provided).…”

“…The authors suggested that this was due to decreased body weights, as there were no differences in absolute organ weights. 40 Sodium alkylbenzene sulfonate. Tusing et al 44 incorporated sodium alkylbenzene sulfonate (0%, 0.5%, or 0.1%) into the feed of albino rats (Carworth Farms; n ¼ 80; 40 female and 40 male) for 104 weeks.…”

Optimisation of saponin extraction conditions with Camellia sinensis var. assamica seed and its application for a natural detergent

“…3,4 Surfactants are the main effective ingredients in detergents, and linear alkylbenzene sulfonate (LAS) and sodium dodecyl sulfate (SDS) are now the world's most commonly used synthetic surfactants in both industrial and household detergents. 5,6 The toxicological information for LAS and SDS suggested that after the oral and subcutaneous administration of LAS, monkeys vomited frequently within 3 h, 7 and SDS had a low LD 50 of 0.8-1.10 g kg −1 in rats. 5 Reports have also indicated that LAS and SDS can damage cell membranes, alter carbon metabolism and cause oxidative stress responses.…”

Lineare Alkylbenzolsulfonate C10–14 [MAK Value Documentation in German language, 2007]

“…Fibrose an den Injektionsstellen war in Inzidenz und Schweregrad dosisabhängig, begleitet von Blutung und Nekrose. Ophthalmoskopie, Laboranalyse von Blut (Differentialblutbild, Blutkörperchensenkung, Prothrombinindex, Blutzucker, Harnstoff, alkalische Phosphatase, Alaninaminotransferase (ALT), Leucin-Aminopeptidase, Bilirubin, Natrium und Kalium) und Urin, Organgewichte und Histologie von Gehirn, Hypophyse, Herz, Lunge, Leber, Milz, Pankreas, Thymus, Prostata, Uterus, Niere, Nebenniere, Schilddrüse und Gonaden zeigten bei allen Dosen keine behandlungsbedingten Änderungen(Heywood et al 1978). Die Dosis von 30 mg/kg KG und Tag oral und simultan subkutan 0,1 mg/kg KG und Tag ist als NOAEL anzusehen.…”

Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics

“…Industrial Bio-Test Laboratories, Inc 40 incorporated SDDBS (0.02%, 0.10%, or 0.50%) into the feed of Beagle dogs (n ¼ 6; 3 males and 3 females) for 104 weeks. Due to poor palatability, the high dose was adjusted to 0.10% in the feed and the remaining dose was administered by capsule (the timing of this adjustment was not provided).…”

“…The authors suggested that this was due to decreased body weights, as there were no differences in absolute organ weights. 40 Sodium alkylbenzene sulfonate. Tusing et al 44 incorporated sodium alkylbenzene sulfonate (0%, 0.5%, or 0.1%) into the feed of albino rats (Carworth Farms; n ¼ 80; 40 female and 40 male) for 104 weeks.…”

Optimisation of saponin extraction conditions with Camellia sinensis var. assamica seed and its application for a natural detergent

“…3,4 Surfactants are the main effective ingredients in detergents, and linear alkylbenzene sulfonate (LAS) and sodium dodecyl sulfate (SDS) are now the world's most commonly used synthetic surfactants in both industrial and household detergents. 5,6 The toxicological information for LAS and SDS suggested that after the oral and subcutaneous administration of LAS, monkeys vomited frequently within 3 h, 7 and SDS had a low LD 50 of 0.8-1.10 g kg −1 in rats. 5 Reports have also indicated that LAS and SDS can damage cell membranes, alter carbon metabolism and cause oxidative stress responses.…”

Lineare Alkylbenzolsulfonate C10–14 [MAK Value Documentation in German language, 2007]

“…Fibrose an den Injektionsstellen war in Inzidenz und Schweregrad dosisabhängig, begleitet von Blutung und Nekrose. Ophthalmoskopie, Laboranalyse von Blut (Differentialblutbild, Blutkörperchensenkung, Prothrombinindex, Blutzucker, Harnstoff, alkalische Phosphatase, Alaninaminotransferase (ALT), Leucin-Aminopeptidase, Bilirubin, Natrium und Kalium) und Urin, Organgewichte und Histologie von Gehirn, Hypophyse, Herz, Lunge, Leber, Milz, Pankreas, Thymus, Prostata, Uterus, Niere, Nebenniere, Schilddrüse und Gonaden zeigten bei allen Dosen keine behandlungsbedingten Änderungen(Heywood et al 1978). Die Dosis von 30 mg/kg KG und Tag oral und simultan subkutan 0,1 mg/kg KG und Tag ist als NOAEL anzusehen.…”

Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics

“…Industrial Bio-Test Laboratories, Inc 40 incorporated SDDBS (0.02%, 0.10%, or 0.50%) into the feed of Beagle dogs (n ¼ 6; 3 males and 3 females) for 104 weeks. Due to poor palatability, the high dose was adjusted to 0.10% in the feed and the remaining dose was administered by capsule (the timing of this adjustment was not provided).…”

“…The authors suggested that this was due to decreased body weights, as there were no differences in absolute organ weights. 40 Sodium alkylbenzene sulfonate. Tusing et al 44 incorporated sodium alkylbenzene sulfonate (0%, 0.5%, or 0.1%) into the feed of albino rats (Carworth Farms; n ¼ 80; 40 female and 40 male) for 104 weeks.…”

Optimisation of saponin extraction conditions with Camellia sinensis var. assamica seed and its application for a natural detergent

“…3,4 Surfactants are the main effective ingredients in detergents, and linear alkylbenzene sulfonate (LAS) and sodium dodecyl sulfate (SDS) are now the world's most commonly used synthetic surfactants in both industrial and household detergents. 5,6 The toxicological information for LAS and SDS suggested that after the oral and subcutaneous administration of LAS, monkeys vomited frequently within 3 h, 7 and SDS had a low LD 50 of 0.8-1.10 g kg −1 in rats. 5 Reports have also indicated that LAS and SDS can damage cell membranes, alter carbon metabolism and cause oxidative stress responses.…”