Toxicological effects of dietary Maillard reaction products in the rat

Effect of glucose-lysine Maillard reaction product fractions on tissue xenobiotic enzyme systems

“…In animals pretreated with B[a]P, the average body weights of animals on diets of FDS and FDMP were 26.8 ± 0.7 and 26.2 ± 0.3 g, respectively, compared to the average weight of 26.8 ± 0.7 g in control animals pretreated with B[a]P. Liver, kidney, intestine, and lung to body weight ratios in animals fed each MRP fraction were similar to those for control animals (Tables II-V). These results are in agreement with other studies on animals fed similar levels of melanoidins (Takeuchi et al, 1987) but contrary to the reported depressed growth of mice fed much higher amounts of melanoidins (Lee et al, 1977;O'Brien and Walker, 1988). Other workers have reported depressed protein digestibility and absorption in rats fed low molecular weight melanoidins (Oste and Sjodin, 1984), whereas the high molecular weight melanoidins had little effect on the growth rate of animals (Olsson et al, 1981).…”

Effect of glucose-lysine Maillard reaction product fractions on tissue xenobiotic enzyme systems

“…In animals pretreated with B[a]P, the average body weights of animals on diets of FDS and FDMP were 26.8 ± 0.7 and 26.2 ± 0.3 g, respectively, compared to the average weight of 26.8 ± 0.7 g in control animals pretreated with B[a]P. Liver, kidney, intestine, and lung to body weight ratios in animals fed each MRP fraction were similar to those for control animals (Tables II-V). These results are in agreement with other studies on animals fed similar levels of melanoidins (Takeuchi et al, 1987) but contrary to the reported depressed growth of mice fed much higher amounts of melanoidins (Lee et al, 1977;O'Brien and Walker, 1988). Other workers have reported depressed protein digestibility and absorption in rats fed low molecular weight melanoidins (Oste and Sjodin, 1984), whereas the high molecular weight melanoidins had little effect on the growth rate of animals (Olsson et al, 1981).…”

Do bread-crust-derived Maillard reaction products affect the retention and tissue distribution of trace elements?

“…Similar results were reported when bottle-sterilized infant formula was used [40]. Other researchers have established that a diet supplemented with 10 % of a heated glutamic-glucose mixture provokes an increase in zinc content in the kidneys [41]. However, previous studies by our own research team have documented decreases in zinc concentrations in the kidney following the intake of MRPs from the methionine-glucose model system in rats [27].…”

Assessing the effects of severe heat treatment of milk on calcium bioavailability: In vitro and in vivo studies

“…Experimental assays performed in rats fed diets containing small proportions of MRP-model systems show disparate results on food intake and weight gain. Thus, depending on the MRP composition, it has been observed that food intake does not vary (Furniss et al, 1989;Delgado-Andrade et al, 2006), tends to be reduced (Seiquer et al, 2001), or is negatively affected (O'Brien and Walker, 1988). However, according to our results, feeding a diet in which all of the protein sources are thermally damaged seems to lead to clear decreases in food intake and body weight gain, as was also observed by Sarriá et al (2001) in rats fed bottle-sterilized infant formulas compared with powder formulas.…”

Effect of glucose-lysine Maillard reaction product fractions on tissue xenobiotic enzyme systems

“…In animals pretreated with B[a]P, the average body weights of animals on diets of FDS and FDMP were 26.8 ± 0.7 and 26.2 ± 0.3 g, respectively, compared to the average weight of 26.8 ± 0.7 g in control animals pretreated with B[a]P. Liver, kidney, intestine, and lung to body weight ratios in animals fed each MRP fraction were similar to those for control animals (Tables II-V). These results are in agreement with other studies on animals fed similar levels of melanoidins (Takeuchi et al, 1987) but contrary to the reported depressed growth of mice fed much higher amounts of melanoidins (Lee et al, 1977;O'Brien and Walker, 1988). Other workers have reported depressed protein digestibility and absorption in rats fed low molecular weight melanoidins (Oste and Sjodin, 1984), whereas the high molecular weight melanoidins had little effect on the growth rate of animals (Olsson et al, 1981).…”

Do bread-crust-derived Maillard reaction products affect the retention and tissue distribution of trace elements?

“…Similar results were reported when bottle-sterilized infant formula was used [40]. Other researchers have established that a diet supplemented with 10 % of a heated glutamic-glucose mixture provokes an increase in zinc content in the kidneys [41]. However, previous studies by our own research team have documented decreases in zinc concentrations in the kidney following the intake of MRPs from the methionine-glucose model system in rats [27].…”

Assessing the effects of severe heat treatment of milk on calcium bioavailability: In vitro and in vivo studies

“…Experimental assays performed in rats fed diets containing small proportions of MRP-model systems show disparate results on food intake and weight gain. Thus, depending on the MRP composition, it has been observed that food intake does not vary (Furniss et al, 1989;Delgado-Andrade et al, 2006), tends to be reduced (Seiquer et al, 2001), or is negatively affected (O'Brien and Walker, 1988). However, according to our results, feeding a diet in which all of the protein sources are thermally damaged seems to lead to clear decreases in food intake and body weight gain, as was also observed by Sarriá et al (2001) in rats fed bottle-sterilized infant formulas compared with powder formulas.…”

Effect of glucose-lysine Maillard reaction product fractions on tissue xenobiotic enzyme systems

“…In animals pretreated with B[a]P, the average body weights of animals on diets of FDS and FDMP were 26.8 ± 0.7 and 26.2 ± 0.3 g, respectively, compared to the average weight of 26.8 ± 0.7 g in control animals pretreated with B[a]P. Liver, kidney, intestine, and lung to body weight ratios in animals fed each MRP fraction were similar to those for control animals (Tables II-V). These results are in agreement with other studies on animals fed similar levels of melanoidins (Takeuchi et al, 1987) but contrary to the reported depressed growth of mice fed much higher amounts of melanoidins (Lee et al, 1977;O'Brien and Walker, 1988). Other workers have reported depressed protein digestibility and absorption in rats fed low molecular weight melanoidins (Oste and Sjodin, 1984), whereas the high molecular weight melanoidins had little effect on the growth rate of animals (Olsson et al, 1981).…”

Do bread-crust-derived Maillard reaction products affect the retention and tissue distribution of trace elements?

“…Similar results were reported when bottle-sterilized infant formula was used [40]. Other researchers have established that a diet supplemented with 10 % of a heated glutamic-glucose mixture provokes an increase in zinc content in the kidneys [41]. However, previous studies by our own research team have documented decreases in zinc concentrations in the kidney following the intake of MRPs from the methionine-glucose model system in rats [27].…”

Assessing the effects of severe heat treatment of milk on calcium bioavailability: In vitro and in vivo studies

“…Experimental assays performed in rats fed diets containing small proportions of MRP-model systems show disparate results on food intake and weight gain. Thus, depending on the MRP composition, it has been observed that food intake does not vary (Furniss et al, 1989;Delgado-Andrade et al, 2006), tends to be reduced (Seiquer et al, 2001), or is negatively affected (O'Brien and Walker, 1988). However, according to our results, feeding a diet in which all of the protein sources are thermally damaged seems to lead to clear decreases in food intake and body weight gain, as was also observed by Sarriá et al (2001) in rats fed bottle-sterilized infant formulas compared with powder formulas.…”