Toxicologic investigations of polyacrylamides

McCollister, D.D.; Hake, Carl L.; Sadek, S.E.; Rowe, V. K.

doi:10.1016/0041-008x(65)90119-5

Cited by 71 publications

(31 citation statements)

References 3 publications

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“…These polymers are formulated into solutions referred to as thickening agents and contain between 25 and 30% polyacrylamide (product labels for NalcoTrol II, Nalco Chemical Co., Napoerville, IL; 38-F and 41-A, Sanag, Los Angeles, CA; DriftGard, Fresno, CA). Polyacrylamide thickening agents have no reported herbicidal properties and are considered nontoxic because of their inability to pass biological membranes (McCollister et al, 1965).…”

Section: Introductionmentioning

confidence: 99%

Environmental Degradation of Polyacrylamides. 1. Effects of Artificial Environmental Conditions: Temperature, Light, and pH

Smith

Prues

Oehme

1996

Ecotoxicology and Environmental Safety

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Section: Introductionmentioning

confidence: 99%

Environmental Degradation of Polyacrylamides. 1. Effects of Artificial Environmental Conditions: Temperature, Light, and pH

Smith

Prues

Oehme

1996

Ecotoxicology and Environmental Safety

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“…Environmental toxicities of PAM and AMD have been published in a number of reports (King and Noss, 1989;Krautter et al, 1986;McCollister et al, 1964McCollister et al, , 1965Petersen et al, 1987;Shanker and Seth, 1986;Walker, 1991). Cationic PAMs have LC 50 values of 0.3-10 ppm.…”

Section: Pam Safety Field Retention and Environmental Impactsmentioning

confidence: 99%

Polyacrylamide in Agriculture and Environmental Land Management

Sojka

Bjorneberg

Entry

et al. 2007

Advances in Agronomy

349

240

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“…8 Although acrylamide itself is genotoxic and neurotoxic, 9 polyacrylamides are nontoxic because of their resistance to biodegradation and their inability to pass through biological membranes due to their large molecular size. 10,11 In this study, the tolerability of a polyacrylamide hydrogel, a new filler material developed for soft-tissue augmentation, was investigated. Polyacrylamide hydrogel has been used in Eastern European countries for more than 10 years, and in 2001, a European Community certificate was granted for its use in facial correction under the trademark of Aquamid (Contura SA, Montreux, Switzerland).…”

mentioning

confidence: 99%

Biocompatibility and Tissue Interactions of a New Filler Material for Medical Use

Zarini

Supino

Pratesi

et al. 2004

Plastic and Reconstructive Surgery

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Filler materials for medical use present limits, such as the induction of chronic inflammation and fibrosis. In the search for synthetic materials with improved biocompatible properties, a new polyacrylamide hydrogel, Aquamid (Contura SA, Montreux, Switzerland), has been investigated in preclinical systems. In cell cultures (endothelial cells and fibroblast), no or only transient biological effects were associated with 10% Aquamid exposure. The Aquamid-host interactions were examined in mice (10 mice per group) implanted subcutaneously or in the mammary fat pad with a very large volume (1.5 ml) of the material. Blood analysis, performed after 15 and 94 days (five mice per time for each group) to detect acute or late manifestations of toxicity, did not reveal relevant abnormalities in either group of Aquamid-bearing mice compared with control mice, except for a transient thrombocytopenia and a mild leukocytosis. Histological analysis of the pellet showed the presence of a thin, poorly vascularized cyst wall in implants. Only mild mesenchymal reparative and inflammatory processes were observed, even at longer observation times (more than 400 days). No alterations in any organ were detected. Despite the large volume implanted (approximately 5 percent of mouse body weight), the Aquamid pellet maintained its original size and shape without spreading or sticking to surrounding tissues. In conclusion, the study indicated a good tolerability of the new biopolymer in preclinical systems. The clinical utility of this new compound, if confirmed by clinical randomized trials showing its atoxic properties, could be in the field of aesthetic plastic surgery as a filler material for body contouring and in reconstructive surgery and above all in cancer patients to restore surgical defects.

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Toxicologic investigations of polyacrylamides

Cited by 71 publications

References 3 publications

Environmental Degradation of Polyacrylamides. 1. Effects of Artificial Environmental Conditions: Temperature, Light, and pH

Environmental Degradation of Polyacrylamides. 1. Effects of Artificial Environmental Conditions: Temperature, Light, and pH

Polyacrylamide in Agriculture and Environmental Land Management

Biocompatibility and Tissue Interactions of a New Filler Material for Medical Use

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