2010
DOI: 10.1016/j.aquatox.2010.02.003
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Abstract: Perfluorooctanesulphonicacid (PFOS), a persistent organic contaminant, has been widely detected in the environment, wildlife and humans, but few studies have assessed its effect on aquatic organisms. The present study evaluated the effect of PFOS on zebrafish embryos. Zebrafish embryos exhibited bent spine and developmental toxicity after exposure to various PFOS concentrations (0.01-16.0 μM) from 6 to 120 hour post-fertilization (hpf). The LC50 at 120 hpf was 4.39 μM and the EC50 at 120 hpf was 2.23 μM. PFOS … Show more

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Cited by 233 publications
(163 citation statements)
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References 47 publications
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“…Likewise, these effects have also been observed in zebrafish embryos exposed to PBDEs [19,20], as well as other toxicants [30,31]. These results suggest that these effects are not neurospecific and may be a general response of fish embryos exposed to toxicants.…”
Section: Discussionmentioning
confidence: 55%
See 1 more Smart Citation
“…Likewise, these effects have also been observed in zebrafish embryos exposed to PBDEs [19,20], as well as other toxicants [30,31]. These results suggest that these effects are not neurospecific and may be a general response of fish embryos exposed to toxicants.…”
Section: Discussionmentioning
confidence: 55%
“…The locomotor behavior of morphologically normal larvae (120 hpf) was monitored in a ZebraLab behavior monitoring station (ViewPoint Life Sciences) equipped with infrared light and visible light sources as described previously [30]. Larvae that were dead or showed deformity were not included in this assay.…”
Section: Behavioral Assaymentioning
confidence: 99%
“…For example, previous studies in Japanese medaka have attributed differences in sensitivity to decreased uptake during chorionated stages, and increased sensitivity to dechorionated stages due to elevated CYP activity (51,52). Other studies have also noted bioavailability-related effects due to the presence of the chorion (58)(59)(60). In fact, Embry et al (61) noted the poorly understood influences of the chorion on bioavailability of various chemicals.…”
Section: Discussionmentioning
confidence: 97%
“…Austin et al [36] reported that PFCs may accumulate in brain in adult rats. Huang et al [25] also found significantly increased apoptosis in the brain and eye regions in zebra fish embryos. Cell apoptosis may also partially contribute to behavioral disruption observed in the present study as the brain is the most important region for planarian behavior response.…”
Section: Discussionmentioning
confidence: 93%
“…Planarian cell apoptosis was identified using acridine orange (AO) staining [25]. After the planarians were exposed to 0, 1, 5, 10, 15, and 25 mg/L PFOA for 7 days or exposed to 10 mg/L PFOA for 2 days, 7 days, and 10 days, the planarians were washed twice in phosphate-buffered saline (PBS) and then transferred to PBS solution containing 5 μg/ml AO and stained for 1 hr at room temperature in the dark.…”
Section: Cell Apoptosismentioning
confidence: 99%