Toxicity, transfer and depuration of anatoxin-a (cyanobacterial neurotoxin) in medaka fish exposed by single-dose gavage

Colas, Simon; Duval, Clément; Marie, Benjamin

doi:10.1016/j.aquatox.2020.105422

Cited by 18 publications

(11 citation statements)

References 32 publications

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“…Kōura (freshwater crayfish; Paranephrops planifrons ) are a culturally significant food source in New Zealand and nodularin from benthic mats have been shown to accumulate in the hepatopancreas and tail tissue (Wood, Phillips, de Winton, & Gibbs, 2012). Preliminary analysis of fish collected from French rivers during benthic cyanobacterial proliferations has revealed the presence of anatoxins in muscle, gut, and encephalon (Colas, Duval, & Marie, 2019).…”

Section: Ecosystem and Human Health Impactsmentioning

confidence: 99%

Toxic benthic freshwater cyanobacterial proliferations: Challenges and solutions for enhancing knowledge and improving monitoring and mitigation

et al. 2020

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This review summarises knowledge on the ecology, toxin production, and impacts of toxic freshwater benthic cyanobacterial proliferations. It documents monitoring, management, and sampling strategies, and explores mitigation options. Toxic proliferations of freshwater benthic cyanobacteria (taxa that grow attached to substrates) occur in streams, rivers, lakes, and thermal and meltwater ponds, and have been reported in 19 countries. Anatoxin‐ and microcystin‐containing mats are most commonly reported (eight and 10 countries, respectively). Studies exploring factors that promote toxic benthic cyanobacterial proliferations are limited to a few species and habitats. There is a hierarchy of importance in environmental and biological factors that regulate proliferations with variables such as flow (rivers), fine sediment deposition, nutrients, associated microbes, and grazing identified as key drivers. Regulating factors differ among colonisation, expansion, and dispersal phases. New ‐omics‐based approaches are providing novel insights into the physiological attributes of benthic cyanobacteria and the role of associated microorganisms in facilitating their proliferation. Proliferations are commonly comprised of both toxic and non‐toxic strains, and the relative proportion of these is the key factor contributing to the overall toxin content of each mat. While these events are becoming more commonly reported globally, we currently lack standardised approaches to detect, monitor, and manage this emerging health issue. To solve these critical gaps, global collaborations are needed to facilitate the rapid transfer of knowledge and promote the development of standardised techniques that can be applied to diverse habitats and species, and ultimately lead to improved management.

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Section: Ecosystem and Human Health Impactsmentioning

confidence: 99%

Toxic benthic freshwater cyanobacterial proliferations: Challenges and solutions for enhancing knowledge and improving monitoring and mitigation

et al. 2020

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“…Toxico-kinetics in fish appears to be fairly rapid. Following oral exposure of adult female medaka fish to a No Observable Adverse Effect Level (NOAEL = 6.67 µg.g -1 of (±)-ATX-a), the toxin could not be detected in the liver after 12h, and in the gut and muscles after 3 days (Colas et al, 2020). Besides, the depuration rate for the 12 first hours is 57, 100 and 90% in guts, livers and muscles, respectively, leading to the rapid excretion of ATX-a.…”

Section: Bioaccumulation and Depurationmentioning

confidence: 99%

Anatoxin-a: Overview on a harmful cyanobacterial neurotoxin from the environmental scale to the molecular target

Colas

Marie

Lance

et al. 2021

Environmental Research

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Anatoxin-a (ATX-a) is a neurotoxic alkaloid, produced by several freshwater planktonic and benthic cyanobacteria (CB). Such CB have posed human and animal health issues for several years, as this toxin is able to cause neurologic symptoms in humans following food poisoning and death in wild and domestic animals. Different episodes of animal intoxication in the wild have incriminated ATX-a, as confirmed by the presence of ATX-a-producing CB in the consumed water or biofilm and/or the observation of neurotoxic symptoms, which match experimental toxicity in vivo.Regarding toxicity parameters, toxicokinetics knowledge is currently incomplete and needs to be improved. The toxin is able to cross passively biological membranes and act rapidly on nicotinic receptors, its main molecular target. In vivo and in vitro acute effects of ATX-a have been studied and make possible to draw its mode of action, highlighting its deleterious effects on the nervous systems and its effectors, namely muscles, heart and vessels, and the respiratory apparatus. However, very little is known about its putative chronic toxicity. This review updates available data on ATXa, from the ecodynamic of the toxin to its physiological and molecular targets.

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“…ANA-a was the first cyanobacterial toxin to be structurally elucidated, and it is an alkaloid component. ANA-a is a potent neurotoxin produced by some planktonic and benthic strains of the genera Anabaena, Oscillatoria, Aphanizomenon and Cylindrospermum (Bouma-Gregson, Kudela, & Power, 2018;Colas, Duval, & Marie, 2020). This toxin is a neurotoxin with a high toxicity (LD 50 mouse = 200-250 μg/kg body weight in rats) (Lanaras & Cook, 1994; and is a potent nicotinic agonist that acts as a postsynaptic that is a depolarising neuromuscular blocking agent.…”

Section: Anatoxin-amentioning

confidence: 99%

Toxic compounds produced by cyanobacteria belonging to several species of the order Nostocales: A review

Nowruzi

Porzani

2020

J of Applied Toxicology

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Toxicity, transfer and depuration of anatoxin-a (cyanobacterial neurotoxin) in medaka fish exposed by single-dose gavage

Cited by 18 publications

References 32 publications

Toxic benthic freshwater cyanobacterial proliferations: Challenges and solutions for enhancing knowledge and improving monitoring and mitigation

Toxic benthic freshwater cyanobacterial proliferations: Challenges and solutions for enhancing knowledge and improving monitoring and mitigation

Anatoxin-a: Overview on a harmful cyanobacterial neurotoxin from the environmental scale to the molecular target

Toxic compounds produced by cyanobacteria belonging to several species of the order Nostocales: A review

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