Toxicity testing of pesticides in zebrafish—a systematic review on chemicals and associated toxicological endpoints

Gonçalves, Íris Flávia Sousa; Souza, Tancredo Augusto Feitosa de; Vieira, Leonardo Rogério; Marchi, Filipi Calbaizer; Nascimento, Adailton Pascoal; Farias, Davi Felipe

doi:10.1007/s11356-020-07902-5

Cited by 60 publications

(15 citation statements)

References 187 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies documented larger fish with deeper bodies and caudal peduncles in flowing water, and relatively dwarfed regions in fish from stagnant water, similar to the present study ( Figure 2 and Figure 3 ); sites sampled in the previous studies overlapped with the present study [ 52 , 71 ]. Hypoxic conditions [ 106 ], sex-specific predation pressure [ 107 ], or endocrine disruptors [ 108 ] and other pollutants [ 109 ] might have also led to the male-biased sex ratio in these populations. Our findings show these measurements can be used in the field to assess population differences.…”

Section: Discussionmentioning

confidence: 99%

Wild Zebrafish Sentinels: Biological Monitoring of Site Differences Using Behavior and Morphology

Kelly

Shelton

Daniel

et al. 2021

Toxics

View full text Add to dashboard Cite

Environmental change poses a devastating risk to human and environmental health. Rapid assessment of water conditions is necessary for monitoring, evaluating, and addressing this global health danger. Sentinels or biological monitors can be deployed in the field using minimal resources to detect water quality changes in real time, quickly and cheaply. Zebrafish (Danio rerio) are ideal sentinels for detecting environmental changes due to their biomedical tool kit, widespread geographic distribution, and well-characterized phenotypic responses to environmental disturbances. Here, we demonstrate the utility of zebrafish sentinels by characterizing phenotypic differences in wild zebrafish between two field sites in India. Site 1 was a rural environment with flowing water, low-hypoxic conditions, minimal human-made debris, and high iron and lead concentrations. Site 2 was an urban environment with still water, hypoxic conditions, plastic pollution, and high arsenic, iron, and chromium concentrations. We found that zebrafish from Site 2 were smaller, more cohesive, and less active than Site 1 fish. We also found sexually dimorphic body shapes within the Site 2, but not the Site 1, population. Advancing zebrafish sentinel research and development will enable rapid detection, evaluation, and response to emerging global health threats.

show abstract

Section: Discussionmentioning

confidence: 99%

Wild Zebrafish Sentinels: Biological Monitoring of Site Differences Using Behavior and Morphology

Kelly

Shelton

Daniel

et al. 2021

Toxics

View full text Add to dashboard Cite

show abstract

“…Regarding insecticides, herbicides and other pesticides, zebrafish ( Danio rerio ) constitutes a useful model to evaluate chemical toxicity in aquatic organisms, as it allows the assessment of different life stages, with several parameters at a low cost ( Gonçalves et al, 2020 ; Schulte et al, 2021 ). Aerial organisms, such as honeybees and other pollinators, should also be considered in order to have a better understanding of ecotoxicity ( Grillo et al, 2021 ).…”

Section: Challenges For Np-based Productsmentioning

confidence: 99%

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

Demarque

Espindola

2021

Front. Chem.

View full text Add to dashboard Cite

Natural products constitute an important source of molecules for product development. However, despite numerous reports of compounds and active extracts from biodiversity, poor and developing countries continue to suffer with endemic diseases caused by arboviral vectors, including dengue, Zika, chikungunya and urban yellow fever. Vector control remains the most efficient disease prevention strategy. Wide and prolonged use of insecticides has resulted in vector resistance, making the search for new chemical prototypes imperative. Considering the potential of natural products chemistry for developing natural products-based products, including insecticides, this contribution discusses the general aspects and specific characteristics involved in the development of drug leads for vector control. Throughout this work, we highlight the obstacles that need to be overcome in order for natural products compounds to be considered promising prototypes. Moreover, we analyze the bottlenecks that should be addressed, together with potential strategies, to rationalize and improve the efficiency of the drug discovery process.

show abstract

“…Recentemente, Gonçalves et al (2020) relataram o grande número de publicações que contribuíram para a demonstração da toxicidade dos agrotóxicos.…”

Section: O Papel Da Ciência Na Avaliação Dos Impactos De Agrotóxicosunclassified

Agrotóxicos: críticas à regulação que permite o envenenamento do país

Hess

Nodari

Lopes-Ferreira

2021

Desenvolv. Meio Ambiente

View full text Add to dashboard Cite

O artigo contém uma análise das autorizações para a comercialização e o consumo de agrotóxicos no país na última década, bem como os seus efeitos na saúde humana e no meio ambiente. No período entre 2010 e 2018, a quantidade de agrotóxicos comercializados no Brasil aumentou mais do que o dobro do que cresceu a área cultivada no país. A permissividade da gestão de agrotóxicos no Brasil é ilustrada pelo fato de que, do total de ingredientes ativos químicos com registro no país em julho de 2020, 121 (30%) não tinham uso permitido na União Europeia (EU). A razão da proibição do uso na EU dos produtos autorizados no Brasil, no período referido, está associada aos efeitos adversos a humanos e a outros organismos resultantes da exposição aos ingredientes químicos de agrotóxicos, já descritos na literatura científica. Soja, milho, algodão e cana-de-açúcar constam entre as culturas que tiveram o maior número de novos agrotóxicos com uso autorizado no Brasil entre janeiro de 2019 e junho de 2020. Outra falta de rigor na gestão de agrotóxicos é ilustrada pela deriva, que causa danos agudos e crônicos a terceiros. Adicionalmente, a fragilidade da norma brasileira refere-se ao estabelecimento de um valor de dose, abaixo da qual eles seriam seguros. Contudo, resultados experimentais de estudos mostraram, por exemplo, que os agrotóxicos à base de glifosato, melation e piriproxifem causaram a morte de embriões de peixes em apenas 24 horas de exposição, independentemente da concentração utilizada, desafiando assim a hipótese de que existe dose segura para a exposição a tais produtos. Dessa forma, é urgente não só aumentar o rigor científico dos estudos sobre o tema, mas também promover a participação pública nas tomadas de decisão, garantindo o acesso a todas as informações contidas nos dossiês que acompanham as solicitações de registro e de autorização dos agrotóxicos.

show abstract

Toxicity testing of pesticides in zebrafish—a systematic review on chemicals and associated toxicological endpoints

Cited by 60 publications

References 187 publications

Wild Zebrafish Sentinels: Biological Monitoring of Site Differences Using Behavior and Morphology

Wild Zebrafish Sentinels: Biological Monitoring of Site Differences Using Behavior and Morphology

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

Agrotóxicos: críticas à regulação que permite o envenenamento do país

Contact Info

Product

Resources

About