Toxicity studies of amphetamine sulfate, ampicillin trihydrate, codeine, 8-methoxypsoralen, α-methyldopa, penicillin VK and propantheline bromide in rats and mice

Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice

“…Dunnick et al reported no clear dose-idependent toxicity with oral gavage 8-MOP at 25 and 50 mg/kg/day for 13 weeks in F344/N rats (22). Furthermore, histopathological lesions and body weight effects were not observed with chronic administration of 8-MOP at the same doses for two years.…”

Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice

“…Dunnick et al reported no clear dose-idependent toxicity with oral gavage 8-MOP at 25 and 50 mg/kg/day for 13 weeks in F344/N rats (22). Furthermore, histopathological lesions and body weight effects were not observed with chronic administration of 8-MOP at the same doses for two years.…”

Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis

“…After surgery (day 0), ampicillin (50 mg/kg body weight) was administered by a subcutaneous injection once a day for five days according to the previous research [59,60]. Ampicillin is a penicillin antibiotic that is used to treat or prevent many different types of infections; its use in rats is associated with very low levels of acute toxicity and demonstrates good safety [61,62]. At day 6, 50 µL of the sterile phosphate-buffered saline (PBS) containing 30 ng (0.6 µg/mL) or 100 ng (2 µg/mL) Noggin protein (BMP-2 inhibitor) [44,63,64] was administered by intra-articular injection into the ACLT-operated knee in the ACLT+30 group or the ACLT+100 group.…”

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

“…If an allergic reaction occurs while taking the medicine, symptoms include: difficulty breathing, skin rash and itching [9]. It is a widely used beta-lactam antibiotics, its toxicology and carcinogenesis studies were performed in rats and toxic lesions of stomach were observed in rats whereas no evidence for carcinogenic activity was found [10][11][12]. Also various metal ions play significant role in our biological system as almost one-third of the enzymes in our body involve metal ions in execution of different biological functions.…”

Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice

“…Dunnick et al reported no clear dose-idependent toxicity with oral gavage 8-MOP at 25 and 50 mg/kg/day for 13 weeks in F344/N rats (22). Furthermore, histopathological lesions and body weight effects were not observed with chronic administration of 8-MOP at the same doses for two years.…”

Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis

“…After surgery (day 0), ampicillin (50 mg/kg body weight) was administered by a subcutaneous injection once a day for five days according to the previous research [59,60]. Ampicillin is a penicillin antibiotic that is used to treat or prevent many different types of infections; its use in rats is associated with very low levels of acute toxicity and demonstrates good safety [61,62]. At day 6, 50 µL of the sterile phosphate-buffered saline (PBS) containing 30 ng (0.6 µg/mL) or 100 ng (2 µg/mL) Noggin protein (BMP-2 inhibitor) [44,63,64] was administered by intra-articular injection into the ACLT-operated knee in the ACLT+30 group or the ACLT+100 group.…”

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

“…If an allergic reaction occurs while taking the medicine, symptoms include: difficulty breathing, skin rash and itching [9]. It is a widely used beta-lactam antibiotics, its toxicology and carcinogenesis studies were performed in rats and toxic lesions of stomach were observed in rats whereas no evidence for carcinogenic activity was found [10][11][12]. Also various metal ions play significant role in our biological system as almost one-third of the enzymes in our body involve metal ions in execution of different biological functions.…”

Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice

“…Dunnick et al reported no clear dose-idependent toxicity with oral gavage 8-MOP at 25 and 50 mg/kg/day for 13 weeks in F344/N rats (22). Furthermore, histopathological lesions and body weight effects were not observed with chronic administration of 8-MOP at the same doses for two years.…”

Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis

“…After surgery (day 0), ampicillin (50 mg/kg body weight) was administered by a subcutaneous injection once a day for five days according to the previous research [59,60]. Ampicillin is a penicillin antibiotic that is used to treat or prevent many different types of infections; its use in rats is associated with very low levels of acute toxicity and demonstrates good safety [61,62]. At day 6, 50 µL of the sterile phosphate-buffered saline (PBS) containing 30 ng (0.6 µg/mL) or 100 ng (2 µg/mL) Noggin protein (BMP-2 inhibitor) [44,63,64] was administered by intra-articular injection into the ACLT-operated knee in the ACLT+30 group or the ACLT+100 group.…”

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

“…If an allergic reaction occurs while taking the medicine, symptoms include: difficulty breathing, skin rash and itching [9]. It is a widely used beta-lactam antibiotics, its toxicology and carcinogenesis studies were performed in rats and toxic lesions of stomach were observed in rats whereas no evidence for carcinogenic activity was found [10][11][12]. Also various metal ions play significant role in our biological system as almost one-third of the enzymes in our body involve metal ions in execution of different biological functions.…”