Toxicity of oleate-based amino protic ionic liquids towards Escherichia coli, Danio rerio embryos and human skin cells

Ortega-Vega, Maria Rita; Baldin, Estela Kerstner; Pereira, Denise Rotta Ruttkay; Martins, Martha Cestari Silva; Pranke, Patrícia; Horn, Fabiana; Pinheiro, Ivone; Vieira, Ana; Espiña, Begoña; Mattedi, Silvana; Malfatti, Célia de Fraga

doi:10.1016/j.jhazmat.2021.126896

Cited by 14 publications

(6 citation statements)

References 57 publications

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“…No significant cardiotoxic effects were observed. 447 (C 8 ) 2 (C 1 ) 2 N Br triggered an adaptation mechanism in the cellular membranes of zebrafish embryos; for this IL, a decrease in the unsaturation index (UI) reflecting membrane fluidity was observed at 24, 48, and 72 h post fertilization (hpf). In the case of (C 6 ) 2 (C 1 ) 2 N Br, a decrease in UI was observed at 48 hpf.…”

Section: Paramisgurnus Dabryanusmentioning

confidence: 97%

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Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

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Section: Paramisgurnus Dabryanusmentioning

confidence: 97%

“…Exposure to HOC 2 NH 3 Ole and HOC 2 C 1 NH 2 Ole led to retarded hatching, whereas HOC 2 NH 3 Ole and (HOC 2 ) 2 NH 2 Ole inhibited free swimming of the larvae. No significant cardiotoxic effects were observed …”

Section: Mechanisms Of Biological Activity Of Ionic Liquids: State Of...mentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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“…124 Protic ILs also show toxicity towards Escherichia coli , Danio rerio embryos and human skin cells. 125 Magina et al reviewed the hazardous effect of ILs and discussed their biodegradability. Moreover, the ecological impact of ILs on various organisms and ecosystems along with fungi, bacteria and cell cultures was also reviewed.…”

Section: Emerging Pollutants and Their Detection Using Graphene Aerogelsmentioning

confidence: 99%

Biomass-based graphene aerogel for the removal of emerging pollutants from wastewater

Tripathi,

Shrivastava,

Dwivedi

et al. 2024

React. Chem. Eng.

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“…Thus, ILs with imidazolium, pyrrolidinium, morpholinium, piperidinium, and ammonium cations usually show obvious toxicity and low degradability [49] . In contrast, the ILs containing choline and protic cations have fairly good biocompatibility [50] . In another work, the anions have exerted a considerable effect on overall toxicity.…”

Section: Design Principles Of Ils For the Tddsmentioning

confidence: 99%

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

Chen,

Li,

Yang

et al. 2024

Asian Journal of Pharmaceutical Sciences

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Toxicity of oleate-based amino protic ionic liquids towards Escherichia coli, Danio rerio embryos and human skin cells

Cited by 14 publications

References 57 publications

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Biomass-based graphene aerogel for the removal of emerging pollutants from wastewater

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

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