Toxicity of dispersant application: Biomarkers responses in gills of juvenile golden grey mullet (Liza aurata)

Milinkovitch, Thomas; Godefroy, Joachim; Théron, Michaël; Thomas, Hélène

doi:10.1016/j.envpol.2011.04.035

Cited by 27 publications

(19 citation statements)

References 51 publications

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“…Increasing knowledge, for example publications included in the Comparative Toxicogenomic Database (http://ctdbase.org), suggests this to be a valid assumption for transcriptional responses. Earlier studies suggest similar toxicity of chemically and mechanically dispersed oil in invertebrates and fishes [5,15,16], or more toxic effects of mechanically dispersed oil than of chemically dispersed oil on copepods and fish [17]. Clark et al [5] showed for several organisms that the dispersants themselves did not alter the toxicity of oils, demonstrated by similar LC50 values for both chemically and mechanically dispersed crude oil.…”

Section: Discussionmentioning

confidence: 97%

Is chemically dispersed oil more toxic to Atlantic cod (Gadus morhua) larvae than mechanically dispersed oil? A transcriptional evaluation

Lie¹,

Nordtug

Hansen

2012

BMC Genomics

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BackgroundThe use of dispersants can be an effective way to deal with acute oil spills to limit environmental damage, however very little is known about whether chemically dispersed oil have the same toxic effect on marine organisms as mechanically dispersed oil. We exposed Atlantic cod larvae to chemically and mechanically dispersed oil for four days during the first-feeding stage of development, and collected larvae at 14 days post hatch for transcriptional analysis. A genome-wide microarray was used to screen for effects and to assess whether molecular responses to chemically and mechanically dispersed oil were similar, given the same exposure to oil (droplet distribution and concentration) with and without the addition of a chemical dispersant (Dasic NS).ResultsMechanically dispersed oil induced expression changes in almost three times as many transcripts compared to chemically dispersed oil (fold change >+/−1.5). Functional analyses suggest that chemically dispersed oil affects partly different pathways than mechanically dispersed oil. By comparing the alteration in gene transcription in cod larvae exposed to the highest concentrations of either chemically or mechanically dispersed oil directly, the chemically dispersed oil affected transcription of genes involved nucleosome regulation, i.e. genes encoding proteins participating in DNA replication and chromatin formation and regulation of cell proliferation, whereas the mechanically dispersed oil most strongly affected genes encoding proteins involved in proteasome-mediated protein degradation. Cyp1a was the transcript that was most strongly affected in both exposure groups, with a 60-fold induction in the two high-exposure groups according to the RT-qPCR data, but no significant difference in transcriptional levels was observed between the two treatments.ConclusionsIn summary, dispersants do not appear to add to the magnitude of transcriptional responses of oil compounds but rather appear to lower or modify the transcriptional effect on cod larvae.

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Section: Discussionmentioning

confidence: 97%

Is chemically dispersed oil more toxic to Atlantic cod (Gadus morhua) larvae than mechanically dispersed oil? A transcriptional evaluation

Lie¹,

Nordtug

Hansen

2012

BMC Genomics

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“…Although this quantitative literature review focused on in vivo studies, a large body of emerging literature has been published on in vitro studies related to oil spill impacts and the use of dispersants [82][83][84][85][86][87][88][89][90]. Although in vitro endpoints can serve as early warning systems of potential sublethal or lethal effects, their usefulness in dispersant use decision making, or in ecological risk assessments related to oil spills (or for other environmental risk assessments), has not been carefully evaluated (e.g., ecological significance of observed effects) or proven reliable (see Nuclear Regulatory Commission [30]).…”

Section: Discussion and Recommendationsmentioning

confidence: 99%

Issues and challenges with oil toxicity data and implications for their use in decision making: A quantitative review

Bejarano¹,

Clark²,

Coelho³

2014

Enviro Toxic and Chemistry

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Aquatic toxicity considerations are part of the net environmental benefit analysis and approval decision process on the use of dispersants in the event of an offshore oil spill. Substantial information is available on the acute toxicity of physically and chemically dispersed oil to a diverse subset of aquatic species generated under controlled laboratory conditions. However, most information has been generated following standard laboratory practices, which do not realistically represent oil spill conditions in the field. The goal of the present quantitative review is to evaluate the use of standard toxicity testing data to help inform decisions regarding dispersant use, recognizing some key issues with current practices, specifically, reporting toxicity metrics (nominal vs measured), exposure duration (standard durations vs short-term exposures), and exposure concentrations (constant vs spiked). Analytical chemistry data also were used to demonstrate the role of oil loading on acute toxicity and the influence of dispersants on chemical partitioning. The analyses presented here strongly suggest that decisions should be made, at a minimum, based on measured aqueous exposure concentrations and, ideally, using data from short-term exposure durations under spiked exposure concentrations. Available data sets are used to demonstrate how species sensitivity distribution curves can provide useful insights to the decision-making process on dispersant use. Finally, recommendations are provided, including the adoption of oil spill-appropriate toxicity testing practices. Environ Toxicol Chem 2014;33:732-742. # 2014 SETAC

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“…Such a treatment of the oil simulated a 12h aging of a slick released at sea 151 (Nordvik 1995). Fish exposures were conducted according to Milinkovitch et al (2011). Fish 152 were allocated to two subgroups (oil-exposed and control, n = 60 fish per group) and 153 transferred from their acclimation tanks to identical, polyethylene tanks (185 L; 3 tanks per 154 treatment) 48h before exposures (biomass per tank 1.46 g L -1 ).…”

Section: Exposures 148mentioning

confidence: 99%

Influence of crude oil exposure on cardiac function and thermal tolerance of juvenile rainbow trout and European sea bass

Anttila

Mauduit

Floch

et al. 2017

Environ Sci Pollut Res

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Oil spills pose a threat to aquatic organisms. However, the physiological effects of crude oil on cardiac function and on thermal tolerance of juvenile fish are still poorly understood. Consequently, in this paper, we will present results of two separate experiments where we exposed juvenile rainbow trout and European sea bass to crude oil and made cardiac thermal tolerances and maximum heart rate (f ) measurements after 1 week (rainbow trout) and 6-month recovery (sea bass). In both species, the f was lower in crude oil-exposed fish than in the control ones at temperatures below the optimum but this difference disappeared at higher temperatures. More importantly, the oil-exposed fish had significantly higher Arrhenius break point temperature for f , which gave an estimate for optimum temperature, than the control fish in both species even though the exposure conditions and recovery times differed between species. The results indicated that exposure of juvenile fish to crude oil did not have a significant negative impact upon their cardiac performance in high temperatures and upper thermal tolerance increased when the fish were tested 1 week or 6 months after the exposure. Our findings suggest that the cardiac function and thermal tolerance of juvenile fish are relatively resistant to a crude oil exposure.

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Toxicity of dispersant application: Biomarkers responses in gills of juvenile golden grey mullet (Liza aurata)

Cited by 27 publications

References 51 publications

Is chemically dispersed oil more toxic to Atlantic cod (Gadus morhua) larvae than mechanically dispersed oil? A transcriptional evaluation

Is chemically dispersed oil more toxic to Atlantic cod (Gadus morhua) larvae than mechanically dispersed oil? A transcriptional evaluation

Issues and challenges with oil toxicity data and implications for their use in decision making: A quantitative review

Influence of crude oil exposure on cardiac function and thermal tolerance of juvenile rainbow trout and European sea bass

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