Toxicity of copper oxide nanoparticles to Neotropical species Ceriodaphnia silvestrii and Hyphessobrycon eques

Mansano, Adrislaine S.; Souza, José Paulo de; Cancino-Bernardi, Juliana; Venturini, Francine Perri; Marangoni, Valéria S.; Zucolotto, Valtencir

doi:10.1016/j.envpol.2018.09.020

Cited by 43 publications

(22 citation statements)

References 66 publications

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“…The 10 mg/L chronic exposure affected reproduction, lowered reproductive stress, prolonged parturition time, and increased the mortality rate, indicating toxicity for both mature fish and larvae [173]. CuO-NPs had negative impacts on the freshwater organisms and Hyphessobrycon eques, specifically on feeding, reproduction, and survival, with an increase in ROS, representing the potential CuO-NP effect on fresh water species [174]. In another study, CuNPs and CuSO 4 were examined with adult male catfish (Clarias batrachus), where testis-related genes showed regulation, an increase in the level of androgens, and disruption in the structural analysis [175].…”

Section: Overview Of Organ Toxicity In Fish Induced By Copper and Copper Oxide Nanoparticlesmentioning

confidence: 99%

Review of Copper and Copper Nanoparticle Toxicity in Fish

et al. 2020

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This review summarizes the present knowledge on the toxicity of copper and copper nanoparticles (CuNPs) to various fish species. In previous decades, the excessive usage of metal and metallic nanoparticles has increased significantly, increasing the probability of the accumulation and discharge of metals in various trophic levels of the environment. Due to these concerns, it is important to understand the toxicity mechanisms of metals and metallic nanoparticles before they lead to unhealthy effects on human health. In this review paper, we specifically focus on the effect of metal copper and CuNPs on different fish organs under different physiochemical parameters of various water bodies. Nowadays, different forms of copper have distinctive and specific usages, e.g., copper sulfate is a well-established pesticide which is used to control the growth of algae in lakes and ponds. Deactivating the fungi enzymes prevents fungal spores from germinating. This process of deactivation is achieved via the free cupric ions, which are established as the most toxic forms of copper. Complexes of copper with other ligands may or may not be bioavailable for use in aquatic organisms. On the other hand, CuNPs have shown cost-effectiveness and numerous promising uses, but the toxicity and availability of copper in a nanoparticle form is largely unknown, Additionally, physiochemical factors such as the hardness of the water, alkalinity, presence of inorganic and organic ligands, levels of pH, and temperature in various different water bodies affect the toxicity caused by copper and CuNPs. However, comprehensive knowledge and data regarding the pattern of toxicity for copper metal ions and CuNPs in marine organisms is still limited. In this review, we carry out a critical analysis of the availability of the toxicological profiles of copper metal ions and CuNPs for different fishes in order to understand the toxicity mechanisms of copper and CuNPs. We believe that this review will provide valuable information on the toxicological profile of copper, which will further help in devising safe guidelines for the usage of copper and CuNPs in a sustainable manner.

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Section: Overview Of Organ Toxicity In Fish Induced By Copper and Copper Oxide Nanoparticlesmentioning

confidence: 99%

Review of Copper and Copper Nanoparticle Toxicity in Fish

et al. 2020

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“…Rod-shaped CuO NPs induce significant decrease in reproduction, feeding inhibition and increase in ROS generation in Neotropical fish species (Ceriodaphnia silvestrii and Hyphessobrycon eques) 16 .…”

Section: Introductionmentioning

confidence: 99%

Histopathological changes and antioxidant responses in common carp (Cyprinus carpio) exposed to copper nanoparticles

Noureen

Jabeen

Tabish

et al. 2019

Drug and Chemical Toxicology

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Despite the rapid increase of nanotechnology in a wide array of industrial sectors, the biosafety profile of nanomaterials remains undefined. The accelerated use of nanomaterials has increased the potential discharge of nanomaterials into the environment in different ways. The aquatic environment is mainly susceptible as it is likely to act as an ultimate sink for all contaminants. Therefore, this study assessed the toxicological impacts of waterborne engineered copper nanoparticles (Cu-NPs) on histology, lipid peroxidation (LPO), catalase (CAT) and glutathione (GSH) levels in the gills of common carp (Cyprinus carpio). Nanoparticles were characterized by XRD and SEM techniques. Before starting the sub-acute toxicity testing, 96hrs LC50 of Cu-NPs for C. carpio was calculated as 4.44mg/l. Then based on LC50, C. carpio of 40-45g in weight were exposed to three sub-lethal doses of waterborne engineered Cu-NPs (0 or 0.5 or 1 or 1.5 mg/l) for a period of 14 days. The waterborne Cu-NPs have appeared to induce alterations in gill histology and oxidative stress parameters in a dose-dependent manner. The gill tissues showed 2 degenerative secondary lamellae, necrotic lamella, fused lamella, necrosis of the primary and secondary lamella, edema, complete degeneration, epithelial lifting, degenerative epithelium and hyperplasia in a dose-dependent manner. In the gill tissues, waterborne Cu-NPs caused a decreased level of CAT and elevated levels of LPO and GSH in the fish exposed to the highest dose of 1.5mg Cu-NPs /l of water. Our results indicate that the exposure to waterborne Cu-NPs was toxic to the aquatic organisms as shown by the oxidative stresses and histological alterations in C. carpio, a freshwater fish of good economic value.

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“…Metabolomics is the method for quantitative analysis of the overall variation of metabolic substances in a certain period, which can rsthand re ect the nal status of biosystems, and it can reveal the relationship between metabolites and physiological or pathological changes [21]. Various studies have showed that the metabolites play a key role in phenotypic regulation and biological synthesis by interacting with genes and proteins [22,23]. Indeed, the changes of intracellular metabolites may reveal the metabolic pathway during the process of apoptosis [24].…”

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confidence: 99%

Metabolomics Reveals the Effects of Copper on Mitochondria-mediated Apoptosis in Kidney of Chicken (Gallus Gallus)

Liao¹,

Yang²,

Bai³

et al. 2021

Preprint

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Background: Copper (Cu), a common feed additive in diets for animals, is effective in improving growth performance and feed efficiency. However, excessive intake of Cu can cause toxic effects. Kidney is the main target organ of Cu, but the relationship between Cu-induced nephrotoxicity and its metabolic process remains unclear.Results: For deeply investigating the nephrotoxicity induced by Cu, a total of 240 broiler chicks were fed with different contents of Cu (11, 110, 220, and 330 mg/kg Cu) for 49 d in this study (60 chicks per group). The results of TUNEL staining showed that Cu could induce apoptosis in kidney with increasing of TUNEL-positive cells. Additionally, a total of 62 differential metabolites were detected by liquid chromatography-mass spectrometry (LC-MS), and mainly enriched in the metabolic pathways including riboflavin metabolism, glutathione metabolism, sphingolipid metabolism, and glycerophospholipid metabolism, which were closely related to mitochondrial metabolism. Meanwhile, the decrease of mitochondrial membrane potential, impairment of mitochondrial respiratory function, and the increase of mitochondrial membrane permeability indicated that renal mitochondria were damaged by excess Cu. Furthermore, the increase of mRNA and protein levels of Drp1, Bax, Bak-1, CytC, Caspase-3/cleaved Caspase-3 and the decrease of mRNA and protein levels of OPA1, Mfn1, Mfn2, and Bcl-2 confirmed that Cu could induce mitochondria-mediated apoptosis in kidney.Conclusions: These results highlighted that mitochondrial metabolism could be considered as an important factor in influencing Cu toxicity, which for further demonstrating that Cu could induce mitochondria-mediated apoptosis in kidney of broilers.

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Toxicity of copper oxide nanoparticles to Neotropical species Ceriodaphnia silvestrii and Hyphessobrycon eques

Cited by 43 publications

References 66 publications

Review of Copper and Copper Nanoparticle Toxicity in Fish

Review of Copper and Copper Nanoparticle Toxicity in Fish

Histopathological changes and antioxidant responses in common carp (Cyprinus carpio) exposed to copper nanoparticles

Metabolomics Reveals the Effects of Copper on Mitochondria-mediated Apoptosis in Kidney of Chicken (Gallus Gallus)

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